Organizations: Department of Computer Science, Nazarbayev University, Astana · Department of Computer Science, Nnamdi Azikiwe University, Nigeria
Abstract
Brain tumors represent one of the most critical neurological conditions, where early and accurate diagnosis is directly correlated with patient survival rates. Manual interpretation of Magnetic Resonance Imaging (MRI) scans is time-intensive, subject to inter-observer variability, and demands significant specialist expertise. This paper proposes a deep learning framework for automated four-class brain tumor classification distinguishing glioma, meningioma, pituitary tumor, and healthy brain tissue from a dataset of 7,023 MRI scans. The proposed system employs a Vision Transformer (ViT-B/16) pretrained on ImageNet-21k as the backbone, augmented with a clinically motivated preprocessing and training pipeline. Contrast Limited Adaptive Histogram Equalization (CLAHE) is applied to enhance local contrast and accentuate tumor boundaries invisible to standard normalization. A two-stage fine-tuning strategy is adopted: the classification head is warmed up with the backbone frozen, followed by full fine-tuning with discriminative learning rates. MixUp and CutMix augmentation is applied per batch to improve generalization. Exponential Moving Average (EMA) of weights and Test-Time Augmentation (TTA) further stabilize and boost performance. Attention Rollout visualization provides clinically interpretable heatmaps of the brain regions driving each prediction. The proposed model achieves a test accuracy of 99.29%, macro F1-score of 99.25%, and perfect recall on both healthy and meningioma classes, outperforming all CNN-based baselines
Classifying brain tumors using magnetic resonance imaging (MRI) is crucial for early diagnosis and treatment; however, tumor heterogeneity and a dearth of annotated datasets restrict the use of supervised deep learning approaches. In this work, we use self-supervised learning (SSL) to study multi-class brain tumor classification. Using a ResNet-50 backbone, we evaluate four SSL frameworks including SimCLR, BYOL, DINO, and Moco v3 on a publicly available dataset of 4,448 MRIs with 17 distinct tumor types. On the dataset, SimCLR achieved 99.64% accuracy, 99.64% precision, 99.64% recall, and 99.64% F1-score. The workflow includes preprocessing, fine-tuning, linear evaluation, and SSL pretraining with data augmentations. Results show that, when labels are limited, SSL-pretrained models outperform supervised baselines in terms of F1-score, recall, accuracy, and precision. Additionally, by providing visual insights into model decisions, Explainable AI techniques (Grad-CAM, Grad-CAM++, EigenCAM) enhance interpretability. These results demonstrate SSL's scalability and dependability in diagnosing brain tumors from unlabeled medical data.
Abrar Hossain Zahin, Amit Kumar Saha, Tanvir Mridha +5
Accurate brain tumor classification from magnetic resonance imaging (MRI) is a key requirement for early diagnosis and clinical decision-making. Vision Transformers (ViTs) have shown strong performance in medical image analysis by learning global contextual representations, but they often fail to capture intrinsic structural and topological patterns present in tumor regions. To address this limitation, we propose a fusion framework that combines Topological Data Analysis (TDA) features with pretrained Vision Transformer representations for four-class brain tumor classification. In the proposed method, TDA is used to extract complementary topological descriptors that capture geometric structure, connectivity, and shape information from MRI images. In parallel, a pretrained ViT model learns high-level semantic representations from the same images. These two feature spaces are then fused to form a unified and more discriminative representation for classification. The model is evaluated on the BRISC2025 dataset, which contains four brain tumor classes: glioma, meningioma, pituitary tumor, and non-tumor cases. Experimental results show that combining topological and transformer-based features significantly improves performance compared to using either approach alone. The proposed TDA-ViT fusion model achieves an accuracy of 99.10%, precision of 99.27%, recall of 99.15%, F1-score of 99.21%, and an AUC of 99.98%. It also outperforms several state-of-the-art models, including ResNet50, ResNet101, EfficientNetB2, and standalone Vision Transformers. These results demonstrate that topological features provide valuable complementary information that enhances deep representation learning, leading to a robust and highly accurate framework for automated brain tumor classification.
Improving patient outcomes depends on the prompt and accurate diagnosis of brain tumors, but manual MRI scan analysis is still time-consuming and unreliable. Although deep learning has shown promise, many of the models that are now in use are computationally intensive and have difficulty handling the intrinsic complexity and variety of different types of brain tumors. In this work, we propose a lightweight yet high-performing Convolutional Neural Network (CNN) for multi-class brain tumor classification, employing MRI images to target gliomas, meningiomas, pituitary tumors, and healthy (no tumor) instances. The model was rigorously evaluated on two publicly accessible datasets from Figshare and Kaggle. Leveraging efficient feature extraction and optimized training strategies, our CNN achieved classification accuracies of 99.03% and 99.28%, along with ROC scores of 99.88% and 99.94% on Dataset 1 and Dataset 2, respectively-all while utilizing significantly fewer parameters than popular pre-trained architectures. In contrast to cutting-edge models like DenseNet201, MobileNetV2, VGG19, Xception, InceptionV3, and ResNet50, our approach consistently demonstrated superior performance with reduced computational overhead. These findings highlight the potential of the proposed model as a practical and reliable diagnostic aid in clinical environments.