MuCALD-SplitFed: Causal-Latent Diffusion for Privacy-Preserving Multi-Task Split-Federated Medical Image Segmentation

Split Federated Learning (SplitFed) combines federated and split learning to preserve privacy while reducing client-side computation. However, in medical image segmentation, heterogeneous label quality across clients can significantly degrade performance. We propose SplitFed-CL, a co-learning framework where a global teacher guides local students to detect and refine unreliable annotations. Reliable labels supervise training directly, while unreliable labels are corrected via weighted student--teacher refinement. SplitFed-CL further incorporates consistency regularization for robustness to input perturbations and a trainable weighting module to balance loss terms adaptively. We also introduce a novel difficulty guided strategy to simulate human like boundary centric annotation errors, where the degree of perturbation is governed by shape complexity and the associated annotation difficulty. Experiments on two multiclass segmentation datasets with controlled synthetic noise, together with a binary segmentation dataset containing real-world annotation errors, demonstrate that SplitFed-CL consistently outperforms seven state-of-the-art baselines, yielding improved segmentation quality and robustness.

Multi-organ segmentation using deep learning requires large amounts of annotated patient data; however, institutions often lack sufficiently large and diverse annotated datasets. Privacy constraints further prevent institutions from sharing patient data to overcome this limitation. Moreover, due to the labor-intensive nature of annotation and the scarcity of diverse expertise, institutions typically have labels for only a small portion of their local data, leaving the larger unlabeled portion unused. In this work, we propose a flexible semi-supervised federated multi-task student-teacher framework that leverages federated learning (FL) to improve multi-organ segmentation using both labeled and unlabeled data across participating sites. At each communication round, the proposed framework initiates local training, where clients with labels for the same task form a federation to produce an aggregated teacher model. The resulting teachers generate task-specific features for all data at each client. Subsequently, all clients form a second federation to train a multi-task student model with a shared encoder and task-specific decoders that replicate the teacher-generated features across all segmentation tasks. The aggregated student model is then used to update the local teachers and initiate the next training round. Extensive experiments demonstrated the effectiveness of the proposed method compared with local and federated single-organ models, yielding an average performance gain of 13 percent across clients. The experiments also demonstrated the impact of multi-task learning and unlabeled data and the applicability of the framework in relaxing labeled-data requirements for client participation. The code is available at https://github.com/AshknMrd/FedMust.

Federated Learning (FL) enables collaborative training of machine learning models across multiple institutions without sharing sensitive data, making it particularly suitable for medical imaging applications. However, heterogeneous data distributions across institutions and potential information leakage through model updates remain important challenges. In this work, we propose DP-SimAgg, a privacy-preserving federated learning framework that integrates similarity-weighted aggregation with a server-side differential privacy mechanism. The proposed method applies L2 clipping to bound collaborator updates, computes similarity-based aggregation weights to mitigate the effects of non-IID data distributions, and injects calibrated Gaussian noise at the central server, providing per-round privacy guarantees under the assumed sensitivity bound. The framework is implemented using Intel's OpenFL platform and evaluated on the FeTS 2022 dataset consisting of 1251 multi-modal MRI scans for brain tumor segmentation. Experimental results demonstrate that DP-SimAgg maintains competitive segmentation performance while providing privacy protection. Under a strict per-round privacy budget (epsilon = 1, cumulative epsilon_total = 20 over 20 rounds), the method achieves Dice scores of 0.6357, 0.5305, and 0.5274 for the enhancing tumor (ET), tumor core (TC), and whole tumor (WT) regions, respectively. With a more relaxed per-round budget (epsilon = 10, cumulative epsilon_total = 200), performance approaches that of the non-private baseline while incorporating a central Gaussian mechanism with per-round (epsilon, delta)-DP accounting under the assumed sensitivity bound. These results highlight the potential of DP-SimAgg for enabling privacy-preserving collaborative learning in medical imaging applications.