Improving TMS EEG Signal Quality for Closed-Loop Neuro Stimulation via Source-Domain Denoising

Electroencephalography (EEG) is highly susceptible to artifact contamination, such as electrooculographic (EOG) and electromyographic (EMG) interference, which severely degrades signal quality and hinders reliable interpretation in applications including neurological diagnosis, brain-computer interfaces (BCIs), etc. Effective EEG denoising remains challenging because different artifact sources exhibit diverse and temporally varying distributions, together with distinct spectral characteristics across frequency bands. To address these issues, we propose BandRouteNet, an adaptive frequency-aware neural network for EEG denoising that jointly exploits band-specific processing and full-band contextual modeling. The proposed model performs band-wise denoising to explicitly capture frequency-dependent artifact patterns. Within this framework, we introduce a routing mechanism that adaptively determines where and to what extent denoising should be applied across temporal locations within each frequency band. In parallel, a full-band conditioner directly processes the original noisy EEG to extract global temporal context, producing both conditional parameters for modulating the band-wise pathway and a coarse-grained signal-level refinement to supplement the final reconstruction. Extensive experiments on the EEGDenoiseNet benchmark dataset demonstrate that BandRouteNet outperforms other methods under EOG, EMG, and mixed-artifact conditions in terms of Relative Root Mean Square Error (RRMSE) and Signal-to-Noise Ratio Improvement (SNR$_{\text{imp}}$) under unified experimental settings, while remaining highly parameter-efficient with only 0.2M trainable parameters. These results highlight its strong potential for high-performance EEG artifact removal in resource-constrained applications.

Electroencephalography (EEG) is a cornerstone of brain-computer interfaces and clinical neuroscience, yet deep learning models are typically trained and evaluated under a single, unreported preprocessing pipeline. We formalize preprocessing choices as a counterfactual intervention space and show that EEG predictions are surprisingly unstable under this space: across six datasets spanning four paradigms, up to 42% of trial-level predictions flip when only the preprocessing changes, a variability that standard uncertainty methods do not explicitly quantify because they condition on a fixed preprocessing pipeline. We provide three tools to make this instability measurable, decomposable, and reducible. First, a Walsh-Hadamard decomposition of the 2^7 pipeline space reveals that sensitivity is near-additive in practice under the binary intervention design, enabling efficient step-by-step optimization. Second, we introduce Preprocessing Uncertainty (PU), a per-trial diagnostic that captures a dimension of instability complementary to model-based confidence. Third, we study Normalized Adaptive PGI (NA-PGI), a graph-structured regularizer that exploits the compositional structure of preprocessing interventions as one mitigation strategy with clear scope conditions.

Reliable seizure prediction is a prerequisite for closed-loop neurostimulation therapy, yet existing methods rarely account for the variability in EEG signal quality encountered in real-world deployment, and the overwhelming majority adopt non-strict evaluation protocols that overestimate generalisation performance. We propose CLSP-REQA (Closed-Loop Seizure Prediction with Real-time EEG Quality Assessment), a unified framework that embeds a lightweight signal quality estimator directly within the prediction pipeline. A Real-time EEG Quality Assessment (REQA) module runs in parallel with a Mamba-BiLSTM backbone, producing a scalar quality score q in [0,1] that modulates output confidence through a tiered non-linear fusion function (ECLO). Under strict cross-patient evaluation on the CHB-MIT Scalp EEG Database (n = 23 subjects, 198 seizures), CLSP-REQA achieves an AUC-ROC of 0.7426 +- 0.0199, outperforming the unadapted cross-patient baseline of 0.69 reported by Jemal et al., using only 16 EEG channels compared to 23 in prior work, and without requiring any target-patient data or domain adaptation. On the SIENA Scalp EEG Database (n = 14 subjects, 47 seizures), CLSP-REQA achieves AUC 0.7012 +- 0.0249, substantially surpassing the best domain-adapted cross-patient result of 0.61 on the same dataset, demonstrating strong cross-dataset generalisation. The framework outputs a structured four-tuple (p, q, c, Phi_SHAP) directly compatible with closed-loop neurostimulator interfaces.