Beyond Toy Benchmarks: A Systematic Evaluation of OOD Detection Methods For Plant Pathology Classification

In out-of-distribution (OOD) detection, fine-tuning with auxiliary outlier data often improves detection performance at the cost of classification accuracy. This trade-off stems from the loss of the original in-distribution (ID) distribution during fine-tuning. To establish a more practical and effective paradigm, we optimize three critical factors: model reminder, data sampling, and representation learning. We propose: (1) Self-Knowledge Distillation (SKD) to mitigate accuracy reduction; (2) Semi-hard Outlier Sampling (SOS) to improve detection efficiency with minimal data; and (3) Outlier-aware Supervised Contrastive Learning (OSCL) to promote ID-OOD separability. Optimizing these factors produces cumulative gains, boosting both OOD detection performance and classification accuracy. Our framework outperforms existing methods across diverse benchmarks, particularly in long-tailed scenarios, providing a robust baseline for real-world OOD detection.

Reliable out-of-distribution (OOD) detection is a critical requirement for the safe deployment of machine learning systems. Despite recent progress, state-of-the-art OOD detectors are highly susceptible to adversarial attacks, which undermines their trustworthiness in automated systems. To address this vulnerability, we apply median smoothing to baseline OOD detection scores, balancing clean and adversarial accuracies. Our key insight is that the noisy samples generated for median smoothing can be repurposed to quantify the local instability of the base score. We observe that OOD samples exhibit higher instability under perturbation. Based on this, we propose ROSS, a novel and robust post-hoc OOD detector that leverages the instability of baseline scores to further distinguish between in-distribution (ID) and OOD samples. ROSS achieves symmetric robustness, performing strongly against both score-minimising and score-maximising attacks, unlike prior work. This symmetric defence leads to state-of-the-art robustness, outperforming prior methods by up to 40 AUROC points. We demonstrate ROSS's effectiveness on extensive experiments across CIFAR-10, CIFAR-100, and ImageNet. Code is available at: https://github.com/Abdu-Hekal/ROSS.

Safe deployment of AI methods in medicine requires robust guardrails that detect when input data deviate from the training distribution to ensure that models provide predictions only within their scope of expertise and abstain otherwise. Out-of-distribution (OOD) detection can provide such safeguards and is extensively studied in general computer vision. Yet, it remains underdeveloped in computational pathology, where gigapixel whole-slide images (WSIs), subtle differences between disease subtypes, and variability in tissue preparation pose unique challenges for conventional OOD methods. We propose ZIO, a training-free, multimodal OOD detector for pathology WSIs that leverages vision--language pathology foundation models (FMs). ZIO constructs text and visual prototypes of in-distribution classes and integrates their complementary information through a prototype shrinkage mechanism to derive OOD scores. We provide the ZIO formulation for both slide- and patch-level FMs. We evaluate ZIO across diverse clinically relevant domain shifts, including rare diseases and near-OOD settings. Extensive evaluation of over 14,700 WSIs from five independent consortia shows that ZIO consistently outperforms both unimodal prototypes and 40 state-of-the-art OOD methods. These results demonstrate the benefits of multimodal representation for OOD detection and pave the way towards safer AI deployment in clinical practice.