Multiple Instance Learning

Also known as MIL

Overview

Multiple Instance Learning (MIL) treats an example as a bag of instances and learns to predict from the bag when the informative regions or moments are unknown. It is useful for tasks with labels for whole slides, scans, videos, or documents but few or no labels for individual patches, slices, frames, or passages. Methods range from mean and max pooling to attention, transformers, graphs, and state-space models, often combined with pretrained features, spatial or temporal structure, prototypes, contrastive learning, and pseudo-labels. A central tension is that strong bag-level predictions do not guarantee faithful instance-level evidence, and more complex aggregators do not always outperform simple pooling.

Latest papers

CardsList

96 papers17 papers in the last four weeks, up 89% on the four weeks before. 0.1% of all new papers.

  1. AutoMIL: Automated Multiple Instance Learning for Whole-Slide Image Classification

    Oct 23, 2026Jonas Waibel, Frank Kramer, Dominik MüllerHistopathology Image ClassificationWhole-Slide Image Analysis

  2. LEAF-Mamba: Feature Adaptation and Fusion for Whole Slide Image Analysis

    Oct 21, 2026Lubin Gan, Jing Zhang, Mingjun Ma +3Whole-Slide Image AnalysisFeature Fusion

  3. Phase Transitions in Learning Driven by Extremal Data

    Oct 21, 2026Ethan Levien, Trevor GrandPreMultiple Instance LearningPhase Transitions in Neural Networks

  4. AdaptMIL: Domain Adaptation for Multiple Instance Learning in Digital Pathology

    Oct 20, 2026Ben Vardi, Dana Schonberger, Yuval Friedmann +4Domain AdaptationComputational Pathology

  5. Beyond the Dominant Label: Recovering Coexisting Lesion Evidence with Multiple Instance Learning

    Oct 15, 2026Lubin Gan, Jing Zhang, Xinming Zhang +3Multiple Instance LearningWhole-Slide Image Analysis

  6. Sea-Net: A Small and Inherently Interpretable Neural Network for Time Series Classification

    Oct 13, 2026Ubaid Ur Rehman, Tanmoy MondalInterpretable Time-Series ClassificationTime Series Classification

  7. Morphology-aware deep learning predicts colorectal cancer survival from whole-slide images

    Oct 13, 2026Hikmat Khan, Metin N. Gurcan, Anil Parwani +3Cancer Survival PredictionComputational Pathology

  8. ProtoPur: Prototype-Purity Pseudo-Labeling for Weakly Supervised Instance Learning in Pathology

    Oct 11, 2026Chen Shu, Chengyang Zhang, Boyu Fu +5Weakly Supervised LearningComputational Pathology

  9. UNISON: A Unified Framework for Learning from Scored Bags

    Oct 11, 2026Ofek Kirshenboim, Or Shkuri, Shani Finkelshtein +1Multiple Instance LearningRecommender Systems

  10. C2^2LUE: Clinically Aligned Patient-Level Ultrasound Diagnosis via Evidence-Aware Multi-Instance Learning

    Oct 9, 2026Qin-Yi Zhang, Linying Cao, De-Xing Huang +7Ultrasound Image ClassificationMultiple Instance Learning

  11. Masked Feature Encoding for Large-Scale Whole Slide Image Representation

    Oct 7, 2026Haoyu He, Basile Tessier-Cloutier, Yang Wang +1Whole-Slide Image AnalysisMedical Image Representation Learning

  12. Joint Class-Time Learning for Video Classification with Multi-Instance Partial-Label Learning

    Oct 5, 2026Lingyu Shen, Wei Tang, Fakhri Karray +1Weakly Supervised LearningMultiple Instance Learning

  13. Cross-Modal Contrastive Learning for the Retrieval of Immunotherapy-Associated Molecular Signatures from Histopathology

    Oct 4, 2026Sigrid Vila-Bagaria, Mar Teixidó, Miquel Piñol +3Computational PathologyCross-Modal Retrieval

  14. State-Aware Interaction MIL for Rare Joint Molecular Phenotype Prediction in Colorectal Cancer and Lung Adenocarcinoma

    Oct 4, 2026Dasari Naga Raju, Tripti BametaComputational PathologyMultiple Instance Learning

  15. One Tile, Multiple Instances: Rethinking MIL for Sparse Diagnostic Evidence

    Oct 4, 2026Runsheng Liu, Cheng Jin, Hao Jiang +1Multiple Instance LearningWhole-Slide Image Analysis

  16. Modeling Whole-Slide Images as Dynamic Tumor Microenvironment Fields

    Sep 28, 2026Lei Wu, Jiashuai Liu, Di Zhang +9Cancer Survival PredictionHistopathology Image Classification

  17. Anatomy-Structured Hierarchical MIL for Weakly-Supervised Thoracic Disease Detection in Chest X-rays

    Sep 27, 2026Jeongin Kim, Sohyun Ahn, Seo Young Kang +6Chest X-Ray ClassificationMedical Image Analysis

  18. Towards Whole-Study Screening for Congenital Heart Disease in Fetal Ultrasound Using Multiple Instance Learning

    Sep 25, 2026Mohamed Azzam, Ruobing Liu, Esther C. Ugwueke +8Ultrasound ImagingMultiple Instance Learning

  19. Statistical Testing for Multiple Instance Learning via Selective Inference with Applications to Computational Pathology

    Sep 21, 2026Noriaki Hashimoto, Shuichi Nishino, Teruyuki Katsuoka +7Multiple Instance LearningSelective Inference

  20. Interpretable Multi-Instance Learning Enables Early Prediction of Key Molecular Alterations from Routine Flow Cytometry in Acute Myeloid Leukemia

    Sep 16, 2026Jonathan Legrand, Aguirre Mimoun, Baudouin Denis de Senneville +3Clinical Decision SupportInterpretable ML

  21. Order-Aware 2.5D Multiple Instance Learning for Preoperative MRI-Based Perineural Invasion Risk Assessment in Intrahepatic Cholangiocarcinoma

    Sep 10, 2026Hyunsu Go, Youngung Han, Kyeonghun Kim +11Perineural Invasion PredictionWeakly Supervised Learning

  22. CAR-MIL: Counterfactual Attention Regularization for Multiple Instance Learning

    Sep 8, 2026Imane Chraki, Pierre Marza, Stergios Christodoulidis +1Computational PathologyWeakly Supervised Learning

  23. Weakly-supervised Kidney Tumor Classification from CT Scans with Multi-Instance Learning and Anatomical Filtering

    Sep 7, 2026Joonas Ariva, Dmytro FishmanOOD GeneralizationMedical Image Classification

  24. SlideMix: Enhancing Whole Slide Image Analysis via Multimodal Shuffling

    Aug 31, 2026Chad Wong, Sicheng Chen, Tianyi Zhang +4Data AugmentationHistopathology Image Classification

  25. ADMIL: Attention-Distilled Multiple Instance Learning for Selective Foundation Model Inference in Pathology

    Aug 22, 2026Duncan Stothers, Ren-Chin Wu, William LotterSelective InferenceWhole-Slide Image Analysis

  26. BagShift: Measuring How Patch Selection Changes the Evidence Seen by Whole-Slide MIL

    Aug 16, 2026Ruicheng Yuan, Zhenxuan Zhang, Liwei Hu +4Whole-Slide Image AnalysisMultiple Instance Learning

  27. Test-Time Instance Selection for Improved Whole Slide Image Analysis

    Aug 14, 2026Quoc Anh Nguyen, Sunhong Park, Jin Tae KwakWhole-Slide Image AnalysisHistopathology Image Classification