Frozen Vision Foundation Models (VFMs) with lightweight classification heads are increasingly used in medical imaging because they offer efficient and reproducible deployment. Yet noisy-label learning methods for this frozen-feature regime remain poorly understood, and most existing methods still rely on a small-loss assumption inherited from end-to-end training. We present a controlled benchmark of eight noisy-label methods across five medical datasets, three backbones, two noise types, and five noise rates (150 conditions, 6,000 training runs), evaluated with balanced accuracy. The benchmark shows that there is no universal winner: Friedman ranking over the 150 conditions yields χ2=333.2 (p=4.77×10−68), ELR wins the most conditions (49/150), while CUFIT attains the best mean rank (2.51). The practical cost of method choice grows sharply with noise severity, from 4.5pp on clean data to 18.8pp at asymmetric 40% noise. To explain these benchmark-level patterns, we revisit the small-loss assumption in a representative high-risk regime. Under frozen DINOv2 features, clean and noisy loss distributions overlap by 53--61%, and matched-rate clean-sample detection shows that prediction agreement is markedly more stable than loss ranking under asymmetric noise (3pp vs.\ 13pp precision drop). On ISIC2019 with asymmetric 40% noise, Co-Teaching reaches 68% overall accuracy while collapsing to 35.1% balanced accuracy with zero recall on three minority classes. Together, these results recast noisy-label learning for frozen VFMs as a regime-aware method-selection problem rather than a search for a single dominant algorithm. We conclude with evidence-based guidance and a low-regret feature-space selector for practical recommendation.
Noisy labels are a pervasive challenge in medical image classification, where annotation errors arise from inter-observer variability and diagnostic ambiguity. Although several noise-robust learning methods have been proposed, their evaluation predominantly relies on accuracy-oriented metrics, overlooking the clinical implications of asymmetric error costs. In medical diagnosis, a false negative (missed disease) carries substantially higher consequences than a false positive (false alarm), as delayed treatment can directly impact patient outcomes. In this work, we investigate whether noise-robust training methods preserve clinical safety under label noise. We conduct a systematic risk-aware evaluation of the state-of-the-art noise-robust methods Coteaching, DivideMix, UNICON, and a GMM-based filtering approach on binarized DermaMNIST and PathMNIST datasets under clean and label noise rates of 20%, and 40%. Beyond balanced accuracy, we adopt a cost-sensitive Global Risk formulation that explicitly penalizes false negatives. Our analysis reveals that the robustness of state-of-the-art methods does not guarantee clinical safety. Furthermore, we demonstrate that integrating cost-sensitive optimization into noise-robust training significantly reduces clinical risk, while mantaining model utility. These findings demonstrate that noise-robust learning must be evaluated through a clinical risk lens, and that combining robust training with cost-sensitive optimization can meaningfully reduce risk in noisy-label medical imaging scenarios.
Semi-supervised adaptation of vision foundation models (VFMs) commonly freezes the pretrained backbone and updates lightweight modules such as LoRA. However, pseudo-labels have mixed reliability, and a single LoRA adapter must absorb reliable, ambiguous, and noisy gradients in the same low-rank space. This can make VFM adaptation sensitive to pseudo-label noise. We propose \textbf{TriNoL}, a \textbf{Tri}ple-expert learning framework from \textbf{No}isy \textbf{L}abels for semi-supervised VFM adaptation. TriNoL routes unlabeled samples into three confidence regions and assigns them to three LoRA experts: a Positive Expert for high-confidence pseudo-labels, an Alignment Expert for medium-confidence ambiguous samples, and a Negative Expert for low-confidence noisy samples. The VFM backbone remains frozen, and only the LoRA experts and classifier head are updated. By separating different pseudo-label reliability regions into specialized adaptation paths, TriNoL improves robustness to noisy supervision while keeping the training cost low.
Noisy labels remain a critical challenge for training deep neural networks, since memorizing incorrect labels degrades generalization. Once noisy samples are identified after training, the standard solution is to retrain the model from scratch on the cleaned dataset, which is increasingly expensive as datasets and models grow. Machine Unlearning (MU) has recently emerged as a computationally efficient alternative, but the relative effectiveness of different MU strategies for noisy-label correction remains poorly understood. In this work, we conduct a comparative empirical study of five MU methods (NegGrad, Fine-Tuning (FT), Random Labeling (RL), SalUn, and MUNBa) across symmetric, asymmetric, instance-dependent, and open-set noise on CIFAR-10, CIFAR-100, and the real-world noisy dataset Food-101N. Our central finding is that the appropriate unlearning strategy is conditioned on the noise structure. Simple FT is a strong baseline across most closed-set scenarios; RL and SalUn are the most consistently robust methods and, under instance-dependent noise, approach retraining accuracy at a fraction of the computational cost; MUNBa shows advantages mainly under extreme symmetric noise. Under open-set noise, in contrast, we show that retraining on the cleaned subset degrades accuracy relative to the noisy baseline, so approximating the retrained model is not an adequate objective in this regime. On Food-101N, all MU methods remain competitive and achieve accuracies close to retraining despite reducing runtime by an order of magnitude. These findings provide practical guidelines for selecting MU strategies for post-training noisy-label correction.