Immuno-VLM: Immunizing Large Vision-Language Models via Generative Semantic Antibodies for Open-World Trustworthiness

Large Vision-Language Models (LVLMs) have advanced multimodal understanding, yet their reliability is limited by hallucination, where generated content conflicts with visual facts. Existing mitigation methods either rely on costly external interventions, such as instruction tuning and retrieval, or use internal mechanisms that remain limited by flawed attention weights and entangled hidden representations. We propose Adversarial Orthogonal Disentanglement (AOD), a latent geometric framework for mitigating LVLM hallucinations. AOD learns a hallucination-related direction through a minimax objective: a classifier concentrates hallucination signals into the projected component, while an adversary removes them from the orthogonal residual space via a Gradient Reversal Layer. The learned direction enables a training-free dual-forward-pass contrastive decoding strategy that suppresses hallucinations while preserving general capabilities. Experiments on three LVLMs across four hallucination and four utility benchmarks show that AOD consistently outperforms strong baselines. It improves POPE accuracy by over 6% on average, boosts AMBER by 6%, and maintains strong performance on utility tasks such as MMMU. Further analysis shows robust transfer across datasets, suggesting that AOD captures general hallucination-related biases rather than dataset-specific artifacts. Our source code and datasets are available at https://github.com/Hunter-Wrynn/AOD.

Large Vision-Language Models (VLMs) have achieved remarkable multimodal performance yet remain prone to factual hallucinations, particularly in long-tail or specialized domains. Moreover, current models exhibit a weak capacity to refuse queries that exceed their parametric knowledge. In this paper, we propose a systematic framework to enhance the refusal capability of VLMs when facing such unknown questions. We first curate a model-specific "Visual-Idk" (Visual-I don't know) dataset, leveraging multi-sample consistency probing to distinguish between known and unknown facts. We then align the model using supervised fine-tuning followed by preference-aware optimization (e.g., DPO, ORPO) to effectively delineate its knowledge boundaries. Results on the Visual-Idk dataset show our method improves the Truthful Rate from 57.9% to 67.3%. Additionally, internal probing also demonstrates that the model genuinely recognizes its boundaries instead of just memorizing refusal patterns. Our framework further generalizes to out-of-distribution medical and perceptual domains, providing a robust path toward more trustworthy and prudent visual assistants.

Vision-language models (VLMs) are now widely used in downstream tasks. However, real-world applications often expose VLMs to distribution shifts induced by semantic variation (e.g., shape, size, and style). Robustness certification determines if a model's prediction changes when transformations are applied to its input. While most certification frameworks study geometric or pixel-level transformations over inputs, this work proposes a novel framework that enables certifying VLM robustness under semantic-level transformations. Leveraging the open-vocabulary capability of VLMs, we use text prompts as semantic proxies to construct transformations parameterized by an extent that controls the degree of semantic variation. By characterizing the VLM decision boundary in closed form, our framework quantitatively certifies extent intervals for which the predicted class remains unchanged under the semantic transformation. Our framework is the first to certify VLM robustness under semantic-level variations without requiring additional data for each variation, making it practical to apply. Experiments on both synthetic and real-world data show that our framework enables certifying robustness under diverse semantic variations across scenarios.