GenEyePose: Patient-Free, Knowledge-Based Saccadic Eye Movement Modeling for Digital Neurophysiologic Biomarker Development
Authors: Tianyu Lin, Jooyoung Ryu, Puvada Sreevarsha, Rahul Srinivasaragavan, Riya Satavlekar, Susan Kim, Nidhi Soley, Yujie Yan, +7 more
Organizations: Whiting School of Engineering, Johns Hopkins University, Baltimore, USA · Johns Hopkins Data Science and AI Institute, Baltimore, USA · NeuroAgent AI, Inc., Baltimore, USA
Eye movements, including saccades, are widely regarded as highly sensitive and objective biomarkers of neurophysiologic states. Detecting saccadic signatures in neurologic diseases offers a rapid, portable alternative to brain imaging, avoiding access and cost barriers. Currently, there are no robust AI-enabled video-oculographic solutions (e.g., digital biomarkers) for screening, triaging, or localizing brain abnormalities due to privacy issues and scarce datasets. In this work, we propose the first fully synthetic, patient-free, multimodal eye movement generation pipeline for generalizable saccade analysis. Using this synthetic dataset, we trained a deep learning classifier to distinguish between normal and abnormal (hypometria and hypermetria) saccadic accuracies and evaluated its performance on real-world clinical data. The model achieved an AUROC of 0.76 and a sensitivity of 0.71, showing that the synthetic data has strong potential to generalize for clinical applications, including as a screening tool in at-home and emergency room settings or a tool for precise neuroanatomic localization.
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Typical machine learning screening methods require PD labels, but the available data is limited by privacy concerns and the need for expert annotation. We propose a label-free face-plus-voice PD screen built entirely on frozen pretrained encoders--a face-expression Vision Transformer and HuBERT--in which no PD label touches any fit; the reference is training controls only. The voice modality uses a synthetic-dysarthria contrastive activation addition (CAA) direction built from time-stretch and breathy degradation of healthy speech; the face modality uses a k-nearest-neighbor anomaly score to the control embedding cluster. We introduce the alignment principle, a post-hoc analysis showing that a synthetic-degradation CAA detector works when the cosine similarity between the synthetic and real disease directions exceeds zero. Measured on the YouTubePD benchmark, this cosine is +0.37 for voice (CAA works, AUROC 0.765) and -0.48 for face (CAA fails; anomaly succeeds, AUROC 0.751). Equal-weight late fusion reaches AUROC 0.802 (95% CI [0.70,0.89]) with NPV 0.95, supporting a rule-out triage interpretation. An overfitting audit shows the voice detector transfers cleanly, while the face-side--and thus fused--AUROC is potentially optimistic pending external validation.
Eye tracking (ET) plays a critical role in augmented and virtual reality applications. However, rapidly deploying high-accuracy, on-device gaze estimation for new products remains challenging because hardware configurations (e.g., camera placement, camera pose, and illumination) often change across device generations. Visual foundation models (VFMs) excel on natural-image benchmarks and offer a promising path to rapid training and deployment; yet, we find that off-the-shelf VFMs still struggle to reach high accuracy on specialized near-eye infrared images. To close this gap, we introduce DistillGaze, a framework that distills a VFM using labeled synthetic data and unlabeled real data for rapid, high-accuracy on-device gaze estimation. DistillGaze proceeds in two stages. First, we adapt a VFM into a domain-specialized teacher using synthetic gaze labels and unlabeled real images. Synthetic data provide scalable, high-quality gaze supervision, while unlabeled real data bridges the synthetic-to-real domain gap. Second, we train an on-device student from both teacher guidance and self-training. Evaluated on a large-scale crowd-sourced dataset spanning more than 2,000 participants, DistillGaze reduces median gaze error by 58.6% relative to synthetic-only baselines while maintaining a lightweight 256K-parameter model suitable for real-time on-device deployment. More broadly, DistillGaze offers an efficient path to training and deploying ET models that adapt to hardware changes, and a recipe for combining synthetic supervision with unlabeled real data in on-device regression tasks.
Sleep is essential for health, yet studying its dynamics requires manual sleep staging, a labor-intensive step in research and clinical care. Across centers, polysomnography (PSG) recordings are traditionally scored in 30-s epochs for pragmatic, not physiological, reasons and vary in electrode count, montage, and subject characteristics. These constraints challenge harmonized multi-center studies and the discovery of robust biomarkers on shorter timescales. We present AnySleep, a deep neural network that scores sleep from any electroencephalography (EEG) or electrooculography (EOG) data at adjustable temporal resolutions. We trained and validated the model on over 20,000 overnight recordings (> 200,000 hours of EEG and EOG) from 28 datasets across multiple clinics to promote robust generalization across sites. The model attains state-of-the-art performance and surpasses or equals established baselines at 30-s epochs. Performance improves with more channels, yet remains strong when EOG is absent or only EOG or single EEG derivations (frontal, central, or occipital) are available. On sub-30-s timescales, the model captures short wake intrusions consistent with arousals and improves prediction of pathophysiological conditions (obstructive sleep apnea, narcolepsy type 1, insomnia) over 30-s scoring. We make the model publicly available to facilitate large-scale studies with heterogeneous electrode setups and accelerate biomarker discovery in sleep.