GenEyePose: Patient-Free, Knowledge-Based Saccadic Eye Movement Modeling for Digital Neurophysiologic Biomarker Development
Authors: Tianyu Lin, Jooyoung Ryu, Puvada Sreevarsha, Rahul Srinivasaragavan, Riya Satavlekar, Susan Kim, Nidhi Soley, Yujie Yan, +7 more
Organizations: Whiting School of Engineering, Johns Hopkins University, Baltimore, USA · Johns Hopkins Data Science and AI Institute, Baltimore, USA · NeuroAgent AI, Inc., Baltimore, USA
Eye movements, including saccades, are widely regarded as highly sensitive and objective biomarkers of neurophysiologic states. Detecting saccadic signatures in neurologic diseases offers a rapid, portable alternative to brain imaging, avoiding access and cost barriers. Currently, there are no robust AI-enabled video-oculographic solutions (e.g., digital biomarkers) for screening, triaging, or localizing brain abnormalities due to privacy issues and scarce datasets. In this work, we propose the first fully synthetic, patient-free, multimodal eye movement generation pipeline for generalizable saccade analysis. Using this synthetic dataset, we trained a deep learning classifier to distinguish between normal and abnormal (hypometria and hypermetria) saccadic accuracies and evaluated its performance on real-world clinical data. The model achieved an AUROC of 0.76 and a sensitivity of 0.71, showing that the synthetic data has strong potential to generalize for clinical applications, including as a screening tool in at-home and emergency room settings or a tool for precise neuroanatomic localization.