Organizations: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA · Department of Computer Science, Emory University, Atlanta, GA, USA · Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA · Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA
Abstract
Objective: Accurate classification of physiological signals in real-world deployments is challenged by sensor noise, motion artifacts, and distribution shifts between training and deployment data. Inference-time augmentation (ITA), which applies augmentations during inference rather than retraining, offers a simple, model-agnostic mechanism to improve robustness. However, ITA application to physiological signals has remained narrow in scope, relying on limited augmentation methods with fixed, unoptimized parameters. This work proposes a unified ITA framework to address that gap. Approach: The framework incorporates 13 augmentation methods spanning time-domain, amplitude-domain, frequency-domain, and artifact-injection transformations, with hyperparameters optimized via Bayesian optimization. We evaluate on atrial fibrillation (AF) detection from 30-second PPG signals using GPT-PPG and ResNet across five datasets comprising more than 400 patients and ∼9,800 hours of recording. Main results: Standard ITA consistently improved AUROC (up to 8.5% for GPT-PPG and 0.7% for ResNet) and AUPRC (up to 10.6% for GPT-PPG and 0.8% for ResNet). Selective ITA further reduced average FPR by up to 4.4% (GPT-PPG) and 1.3% (ResNet) on non-AF datasets. Significance: These findings establish ITA as a practical, model-agnostic approach for improving PPG-based AF classification reliability in deployment settings where retraining is not feasible, with broader applicability to physiological signal analysis.
Photoplethysmography (PPG), a non-invasive measure of changes in blood volume, is widely used in both wearable devices and clinical settings. Recent PPG foundation models either use open-source ICU datasets with pretraining paradigms that require curated data and thus complicate generalization to field-like data, or use closed-source field-like PPG data. In contrast, we propose a PPG foundation model that does not require high-quality or field-like pretraining data, and instead leverages accompanying electrocardiogram and respiratory signals in ICU datasets to select contrastive samples during pretraining. Our approach allows the model to retain and learn from noisy PPG segments, improving robustness at inference. Our model, pretrained on 3x fewer subjects than existing state-of-the-art approaches, achieves performance improvements on 14 out of 15 diverse downstream tasks, including field-like daily activity and heart rate prediction. Our results demonstrate that multimodal supervision can integrate complementary physiological information to improve the robustness of PPG foundation models and enhance their generalization to consumer-grade data.
Remote photoplethysmography (rPPG) enables non-contact heart-rate estimation from facial videos, but its weak physiological signal is easily corrupted by motion, illumination changes, occlusion, skin-appearance variation, and device noise. Existing rPPG methods typically rely on a single model to directly predict heart rate or recover pulse waveforms, while different strong estimators may produce conflicting yet individually plausible candidates for the same video. To resolve these conflicts, we propose PhysAgent, an inference-time multi-agent candidate-verification framework. Unlike direct prediction approaches, PhysAgent neither trains a new base rPPG model nor asks Multimodal Large Language Models (MLLMs) to output heart rate directly. In contrast, it treats outputs from multiple base estimators as physiological hypotheses to be verified and uses a lightweight 4B MLLM, Qwen3-VL-4B, to drive multi-agent reasoning over video conditions, signal reliability, and candidate disagreement. A deterministic physiological verifier checks the fusion proposal, and a reproducible numerical fusion process produces the final heart rate. Experimental results on multiple public rPPG benchmarks show that PhysAgent improves fusion stability and reliability across different datasets and source-domain settings, while avoiding the irreproducibility and physiological inconsistency of direct MLLM prediction or unconstrained ensemble fusion. The code will be released soon.
Contrastive representation learning struggles on physiological signals when each subject contributes a distinct baseline pattern. If class differences overlap with subject differences,class-level objectives such as supervised contrastive learning tend to merge per-subject structure into a single per-class cluster,removing the individual variation that a model needs to generalize to unseen patients. We study this problem in the setting of Paroxysmal Atrial Fibrillation(PAF) detection from RR-interval(RRI) sequences and propose a patient-aware contrastive objective that forms positive pairs only from same-patient, same-class segments, preserving each patient's own sinus rhythm(SR) baseline while still pushing the two classes apart. Examining the learned embeddings directly, our objective achieves the most consistent per-patient SR structure (cohesion 0.850 vs. 0.800 for supervised contrastive loss (SupCon) and 0.772 for binary cross-entropy (BCE)). We also identify that BCE produces the cleanest global class separation yet the most disordered per-patient structure. This is precisely why a linear probe trained on its features breaks down on unseen patients. On the IRIDIA-AF dataset, the resulting representation reaches a patient-independent Area Under the Receiver Operating Characteristic Curve (AUROC) of 0.989±0.003 with 2.6× lower seed variance than supervised contrastive baselines.These results highlight that per-subject geometric consistency, rather than global class separability, is key to robust cross-patient generalization.