Task-guided cross-subject latent alignment: a multi-encoder-decoder VAE
Authors: Angeliki Papathanasiou, Jascha Achterberg, Thomas E. Nichols, Rui Ponte Costa
Organizations: Centre for Neural Circuits and Behaviour, Department of Physiology Anatomy and Genetics, University of Oxford · Big Data Institute, Nuffield Department of Medicine, University of Oxford
Aligning neural activity across subjects offers the promise of discovering shared computational principles and generalizable decoders. However, traditional alignment methods require shared stimuli across subjects, a constraint that limits applicability to naturalistic paradigms with limited or non-overlapping data. We introduce a Multi-Encoder-Decoder Variational Autoencoder (MED-VAE) that achieves cross-subject alignment without shared stimuli by anchoring representations to a common scaffold provided by a pretrained ANN. Using the Natural Scenes Dataset, we show that MED-VAE creates common latent spaces with superior semantic organisation, achieving higher cross-subject alignment than common methods while maintaining robust generalisation to held-out stimuli where traditional methods degrade. Reconstructing from these common spaces back to each subject's original neural space, MED-VAE preserves equal stimulus-driven signal in its cross-subject latent space. Finally, we show that this superior alignment directly enables cross-subject neural prediction, as demonstrated via cross-subject image decoding. In summary, we introduce a framework to identify generalisable common subspaces for cross-subject predictions and downstream tasks, demonstrated here for visual cortex responses to static images.
Cross-subject EEG decoding promises more training data, but it also exposes neural networks to strong inter-subject distribution shifts. We study whether task supervision and architecture alone can learn subject-aligned representations. We replace a shared EEG encoder with subject-specific encoders followed by a common classifier, and compare this hybrid model with standard EEGNet, AttentionBaseNet, and CTNet baselines with Euclidean Alignment (EA) on three motor-imagery datasets and one motor-execution dataset. EA improves shared encoders by recentering subject covariances, whereas the hybrid encoder reduces reliance on EA: removing EA has little effect on validation-loss dynamics or latent-space organization, and both hybrid variants consistently outperform non-aligned shared baselines. Subject-specific heads increase class distinctiveness and place each subject close to its own latent manifold while improving within-subject class separation. However, on cross-subject classification, subject-specific heads hinder direct parameter transfer to unseen subjects, motivating quantitative head selection and a brief calibration session. Although decoding gains depend on the dataset and backbone, our main findings concern that the sole use of architecture pressure promotes representation learning and alignment in a direction complementary to domain adaptation methods such as Euclidean Alignment. A per-subject low-rank adapter of only 2Cr parameters recover the full encoder's accuracy across five backbones and ranks r=1 to 16, so the per-subject module can be compressed by two to three orders of magnitude.
Bruna J. Lopes, Gabriel Schwartz, Sylvain Chevallier +2
Deep learning for cross-subject EEG decoding is hindered by high inter-subject variability, which introduces a severe domain shift between training and unseen test subjects. This survey presents a comprehensive review of deep learning methodologies specifically engineered to address this cross-subject generalization challenge. To ground this analysis, we formalize the cross-subject setting as a multi-source domain problem and delineate the rigorous, subject-independent evaluation protocols required for valid assessment. Central to this survey is a systematic taxonomy of the current literature into discrete methodological families, including feature alignment, adversarial learning, feature disentanglement, and contrastive learning. We conclude by examining three critical elements for advancing robust, real-world decoding: the theoretical limitations of current methodologies, the structural value of subject identity, and the emergence of EEG foundation models.
Cross-subject brain-to-visual decoding remains a core challenge in brain-computer interfaces due to severe inter-individual variability that induces systematic subject-specific functional misalignment. To address this issue, we propose MindAdapter, a parameter-efficient few-shot calibration framework for pretrained brain-to-visual decoding models. MindAdapter adopts a decoupled linear-residual cascade alignment paradigm by freezing a pretrained explicit brain functional alignment backbone (coarse) and introducing a lightweight nonlinear residual adapter (fine), thereby disentangling global cross-subject correspondence from subject-specific residual corrections for fine-grained spatial and semantic calibration. To further preserve global representational stability, we design a topology-anchored dual-stream manifold constraint, where a small set of shared stimuli serves as topological pins with voxel-level paired supervision, while a semantic stream enforces consistency through a frozen vision-language decoder on unpaired brain data. Together, MindAdapter efficiently injects subject-specific corrections while maintaining the global representational geometry learned during pretraining. Experiments on the Natural Scenes Dataset (NSD) demonstrate that MindAdapter substantially improves cross-subject visual reconstruction and retrieval accuracy using only a few shared stimuli, offering a practical and data-efficient solution for personalized brain-to-visual decoding.