Prompting Diffusion Models for Zero-Shot Instance Segmentation
Authors: Irem Zeynep Alagöz, Nils Morbitzer, Andrea Ramazzina, Nassir Navab, Federico Tombari, Stefano Gasperini
Abstract
Several disruptive research directions have recently emerged in computer vision, including foundation models achieving previously unseen zero-shot performance in scene understanding, even interactively, and generative models that synthesize extremely realistic images. The latter have also been shown to be highly effective in scene understanding tasks thanks to their rich priors. However, for promptable segmentation, foundation models struggle with accurately segmenting an object's region, leading to false positives and over-segmentation. Notably, early attempts that leverage generative priors use prompts only during post-processing, yielding suboptimal segments because the process is agnostic to the user input. In this paper, we target these limitations with Prompt2Seg, a spatial conditioning framework for diffusion-based segmentation. Prompt2Seg augments a frozen diffusion segmentation model with a conditioning branch. Our approach takes spatial prompts, represented as 2D Gaussians or confidence maps, as explicit input signals, training the model to respond directly to user intent. Fine-tuned on a deliberately constrained set of object categories drawn from Hypersim and Virtual KITTI 2, Prompt2Seg generalizes zero-shot to a wide range of unseen object types and visual domains. We evaluate on seven datasets ranging from standard benchmarks to more challenging domains, including paintings, egocentric views, and X-ray data. Furthermore, we demonstrate that Prompt2Seg consistently outperforms the underlying diffusion segmentation backbone across all benchmarks. Our results suggest that the rich priors encoded in generative pretraining, combined with principled spatial conditioning, offer a compelling path toward broadly generalizing interactive segmentation without large-scale mask supervision.
Diffusion models are primarily trained for image synthesis, yet their denoising trajectories encode rich, spatially aligned visual priors. In this paper, we demonstrate that these priors can be utilized for text-conditioned semantic and open-vocabulary segmentation, and this approach can be generalized to various downstream tasks to make a general-purpose diffusion segmentation framework. Concretely, we introduce DiGSeg (Diffusion Models as a Generalist Segmentation Learner), which repurposes a pretrained diffusion model into a unified segmentation framework. Our approach encodes the input image and ground-truth mask into the latent space and concatenates them as conditioning signals for the diffusion U-Net. A parallel CLIP-aligned text pathway injects language features across multiple scales, enabling the model to align textual queries with evolving visual representations. This design transforms an off-the-shelf diffusion backbone into a universal interface that produces structured segmentation masks conditioned on both appearance and arbitrary text prompts. Extensive experiments demonstrate state-of-the-art performance on standard semantic segmentation benchmarks, as well as strong open-vocabulary generalization and cross-domain transfer to medical, remote sensing, and agricultural scenarios-without domain-specific architectural customization. These results indicate that modern diffusion backbones can serve as generalist segmentation learners rather than pure generators, narrowing the gap between visual generation and visual understanding.
Text-based image segmentation aims to delineate object boundaries within an image from text prompts, offering higher flexibility and broader application scope compared to traditional fixed-category segmentation tasks. Recent studies have shown that diffusion models (e.g., Stable Diffusion) can provide rich multimodal semantic features, leading to studies of using diffusion models as feature extractors for segmentation tasks. Such methods, however, inherit the generative natures of diffusion models that are harmful to discriminative segmentation tasks. In response, we propose RLFSeg, a novel framework that leverages Rectified Flow to learn direct mapping from the image to the segmentation mask within the latent space. The model is thus freed from the noise-denoise process and the need to optimize the time step of diffusion models, resulting in substantially better performance than previous diffusion-based methods, especially on zero-shot scenarios. By introducing label refinement and an Adaptive One-Step Sampling strategy, the model achieves higher accuracy even on a single inference step. The framework redirects a pretrained generative model to the discriminative segmentation task with zero modification to model structure, thus reveals promising application potential and significant research value.
Open-vocabulary segmentation models such as SAM3 perform well across broad categories via text prompting, yet degrade when target classes are visually underrepresented in pretraining or depart from canonical depictions-limitations text prompts cannot resolve spatially. We present SegRAG, a training-free retrieval-augmented segmentation framework that grounds SAM3 with class-specific point prompts derived from a curated DINOv3 feature bank. Offline, dense patch-level descriptors are extracted from annotated references and filtered by Intra-Class Cohesion Distillation (ICCD), retaining only prototypes that reliably retrieve within-class foreground. At inference, Topographic Similarity Grounding (TSG) computes a cosine-similarity landscape against retrieved prototypes, identifies coherent high-confidence regions via connected-component analysis, and extracts peak locations through non-maximum suppression. The resulting point prompts are delivered jointly with class-name text in a single SAM3 forward pass. On four standard benchmarks, SegRAG consistently outperforms the text-only baseline, gaining up to +3.92 mIoU on LVIS. On AgML agricultural benchmarks under zero-shot domain transfer, it raises mean IoU from 25.27 to 59.24 (+33.97) and recovers individual classes from zero to over 95 mIoU. Ablations confirm that ICCD, TSG, and joint prompting each contribute independently and compound when combined. Code is available at (https://github.com/boudiafA/SegRAG).