Superpixel-Based QUBO for Scalable Quantum-Enhanced Medical Image Segmentation

Semantic segmentation in remote sensing is commonly addressed using classical deep learning architectures such as U-Net, which require a large number of parameters to model complex spatial relationships. Quantum machine learning (QML) provides an alternative representation paradigm by mapping classical features into quantum states, but its direct application to high-dimensional images remains challenging under near-term quantum hardware constraints. In this work, we propose HQ-UNet, a hybrid quantum-classical U-Net architecture that integrates a compact parameterized quantum circuit at the bottleneck of a classical U-Net. The proposed design uses a non-pooling quantum convolutional module to enrich highly compressed encoder features before decoding, while keeping the quantum component shallow and parameter-efficient. Experiments on the LandCover.ai dataset show that HQ-UNet achieves a mean IoU of 0.8050 and an overall accuracy of 94.76%, outperforming the classical U-Net baseline. These results suggest that compact quantum bottlenecks can enhance feature representation for remote sensing image segmentation under near-term quantum constraints. This highlights the potential of hybrid quantum-classical designs as a promising direction for parameter-efficient dense prediction in Earth observation.

Quadratic unconstrained binary optimization (QUBO)-based quantum computed tomography (CT) casts reconstruction as a binary quadratic problem for quantum annealing and hybrid quantum--classical solvers. For grayscale CT, however, image encoding is constrained by the binary-variable budget: fixed global bit-plane encodings increase QUBO size and coupling complexity as gray-level precision improves, whereas low-bit encodings introduce quantization error. We propose a QUBO-based grayscale CT reconstruction framework that combines dynamic interval encoding with prior-balanced optimization. Each refinement round encodes active pixels only within local gray-level intervals around the current estimate, and a boundary-hit-guided update rule adaptively switches between search expansion and local refinement. To improve optimization stability, the method balances projection-domain data consistency and an edge-preserving quadratic prior before forming the final QUBO. Sparse-view and limited-angle fan-beam CT experiments show that the proposed method recovers structures and gray-level distributions more faithfully than the evaluated analytic, iterative, variational, and representation-based baselines. Expressivity analysis and ablation studies further indicate that the improvement mainly arises from effective gray-level representation through dynamic local encoding and more stable data-fidelity--prior coupling. Experiments on the D-Wave hybrid binary quadratic model (BQM) solver further demonstrate that the formulation is executable on a hardware-backed hybrid quantum--classical backend.

This work presents a study of an implementation of a novel Quantum Convolutional Neural Network (QCNN) for binary classification of images from the Modified National Institute of Standards and Technology (MNIST) dataset. Using a novel architecture inspired by previous QCNN and classical convolutional neural network (CNN) implementations, we use a hierarchical partitioning approach to implement a QCNN circuit that can be approximated and simulated efficiently on a classical machine for a large problem. First, the original image is partitioned such that each process handles a smaller portion of the image, which is encoded into independent states. Then, these partitions merge and combine, resulting in states that contain information from both partitions while halving the number of processes. After repeating this until one process remains, we reduce the dimensionality of the state until a single qubit remains for measurement. Using this approach, we can use multiple processes in parallel to simulate a large QCNN program without the need for exponentially growing hardware requirements as the number of qubits increases. In our work, we use this scheme to train a 128-qubit model, which is impossible to run on any classical supercomputer without the novel architecture. We also explore the impact of this new model architecture on prediction accuracy by training it to perform binary classification on the MNIST dataset with a small number of qubits, and comparing it to a model without partitioning. Our initial findings show that partitioning images into smaller sub-images with this architecture does not degrade the model's performance and sometimes even improves it, likely because it reduces the Barren plateaus issue in the partitioning process.