TREA-Net: A Transferable Residual Epidemiological Adaptation Network for Dengue Incidence Forecasting

Accurate dengue forecasting is crucial for public health planning, but remains challenging because incidence series are often short, noisy, non-stationary, nonlinear, and often affected by long-range temporal dependence. Fractional differencing in Autoregressive Fractionally Integrated Moving Average (ARFIMA) helps balance non-stationarity and persistence, but its linear structure limits its ability to capture nonlinear dynamics. Deep neural networks can model nonlinear patterns, but usually require large training samples and do not explicitly encode statistical long memory. Echo State Networks (ESNs), a widely used reservoir computing framework, are attractive in this setting because they retain nonlinear recurrent dynamics while training only a simple readout, making them suitable for data-scarce scenarios. However, standard ESNs lack long-term memory from a time-series perspective. This study proposes a long-memory reservoir computing framework that integrates dedicated long-memory and short-memory ESN reservoirs with a ridge-regression readout. We introduce two variants: Fractional ESN (fESN), which incorporates fractional-differencing dynamics into the reservoir to encode long-range dependence directly, and Wavelet ESN (wESN), which extracts stable low-frequency components through wavelet smoothing before modeling them with a memory-aware reservoir. We establish theoretical guarantees for closed-loop reservoir dynamics, showing that standard ESNs induce short-memory processes under mild conditions, whereas the proposed long-memory reservoirs generate polynomially decaying dependence consistent with statistical long memory. Across multiple dengue datasets and forecasting horizons, fESN and wESN outperform statistical and deep learning baselines. Combining conformal prediction with fESN and wESN provides distribution-free calibrated uncertainty intervals.

Weekly influenza surveillance counts guide vaccine distribution and public-health alerts, yet they are hard to forecast. Each region offers only a few seasons, waves shift in timing and height every year, and information that helps while a wave grows misleads after its peak, whereas last season's shape stays informative for a year. Existing epidemic graph models and general forecasters read a short fixed window and treat all past information alike, so they neither exploit earlier seasons nor discard stale associations when the epidemic phase changes. To address these limitations, we propose TERN, a forecaster built around a delta-rule fast-weight memory that decays channel-wise and erases along a learned address under gates driven by local epidemic-phase features, combined with an explicit seasonal reference and online adaptation. On three Cola-GNN influenza benchmarks, TERN outperformed epidemic graph models and general forecasters, matched or exceeded seasonal references, and a controlled comparison confirmed the contribution of the memory itself.

Seasonal influenza infects millions of people and causes substantial morbidity and mortality in the United States each year, making accurate short-term forecasting a core public-health need. Reliable forecasts of epidemic time series can inform vaccination timing, hospital staffing, and resource allocation, yet the comparative behavior of modern forecasting architectures on infectious-disease surveillance data remains insufficiently characterized. We address this gap through a systematic evaluation of regional influenza forecasting using influenza-like illness surveillance and influenza-associated hospitalization time series under both temporal and spatial generalization settings for 1-4-week-ahead prediction. We compare classical neural network architectures, numerical transformer-based models, pretrained time series foundation models, and LLM-based forecasting approaches. Across tasks, we demonstrate that a mixture-of-experts model that fuses multiple pretrained forecasters achieves the strongest overall performance, indicating that heterogeneous pretrained representations provide complementary predictive information. Our results further show that numerical transformer-based models produce reliable forecasts, while pretraining provides the largest gains at longer horizons, particularly when the pretraining domain is mechanistically aligned with influenza dynamics. In contrast, LLM-based time series methods underperform relative to numerical forecasters in this setting. Finally, we examine hospitalization information as both an auxiliary covariate and a pretraining source. Hospitalization signals provide complementary improvements in selected settings and clarify when additional surveillance streams enhance the robustness of multi-horizon forecasting. These findings provide actionable guidance on model selection, pretraining strategy, and auxiliary-signal use for influenza preparedness.