AskChem: Claim-Centered Infrastructure for Chemistry Literature Synthesis

Large language models are increasingly used to assist scientific reading, but existing evaluation methods often fail to detect whether answers are supported by verifiable citations. We introduce ResearchQA, a benchmark of 6,211 single-paper question-answer pairs from 494 open-access papers spanning eight domains and four question types: lookup, comprehension, multi-hop, and adversarial. ResearchQA is designed for citation-grounded evaluation: it permits multiple valid supporting passages for a claim and rewards grounded refusal when the source paper does not support an answer. We evaluate eight leading closed- and open-weight models in a citation-grounded chat-with-paper setting using a deterministic citation matcher and an LLM-based rubric evaluator. Citation-based metrics separate systems more clearly than LLM-evaluator scores: section coverage and citation accuracy vary substantially across models, while evaluator scores remain tightly compressed. We further find that open-weight models approach the best closed-model citation accuracy while achieving 3 to 6 times lower per-example latency. We release the benchmark, evaluation harness, and evaluator prompt.

The web is increasingly accessed by AI agents rather than humans. Every agent needs knowledge, especially in the life-sciences, where agentic pipelines are growing fast. Access to the literature is a crucial part of that need, and resources such as Europe PMC, with over 40M indexed records, are widely used to meet it. Yet these resources were not built for AI agents: they take keywords and complex syntax and return whole papers, so every agent must learn the syntax, issue several searches, and read full papers to find the evidence it needs. We introduce EMBL AI Librarian, a knowledge layer that upgrades the Europe PMC interface for AI agents: an agent asks in natural language and receives evidence that answers it. A single LLM orchestrates the whole knowledge retrieval process: it plans complementary subqueries executed by the live Europe PMC search engine, then reads the selected papers and locates the relevant evidence. We evaluate Librarian across four benchmarks: literature synthesis, claim verification, open-domain question answering, and downstream biology tasks such as protocol questions and sequence manipulation. On ScholarQABench, Librarian improves Citation F1 by more than $16$ points over strong recently published baselines. Used as the retrieval layer of an existing claim-verification pipeline, it increases agreement with expert consensus; and on the open-form LitQA2 benchmark, a GPT-5.4 agent scores about $8$ points higher when grounded in Librarian than with web search. Overall, our results show that equipping life-science agents with the Librarian knowledge layer improves performance across a range of tasks. We release our code publicly at https://github.com/petroni-lab/librarian

Scientific literature is increasingly used as a knowledge source for language models, retrieval-augmented generation systems, and research assistants, but answering research questions from papers requires more than fluent generation. A reliable system must identify the relevant papers, locate the concrete evidence that supports the answer, and produce a response that is faithful to that evidence. We present LitTraceQA, a benchmark for literature-grounded question answering over scientific papers. Given a research question and a metadata pool of papers, a system must return three connected outputs: canonical paper identifiers, supporting evidence locations, and answers in one or more requested formats, including free-form text, multiple-choice answers, and structured tables. LitTraceQA targets evidence types common in scientific reading: tables, figures, text spans, equations or algorithms, and citation contexts. The public development split contains 55 examples, including 26 hidden-source single-paper questions and 29 multi-paper questions, and provides gold papers, evidence annotations, and answers for local validation. We also analyze a larger final annotation collection with 4,978 unique-question records over 4,859 unique gold papers. By evaluating paper retrieval, evidence grounding, and answer accuracy separately, LitTraceQA provides a testbed for scientific QA systems that produce verifiable answers rather than unsupported summaries.