Limitations of Synthetic Data Generation in Specialized Data-Scarce Domains
Authors: Edward Zhang, Marcel Hussing, Tanay Tandon, Shenbagaraj Kannapiran, Jason Hughes, Youkang Wang, Joshua Caswell, Agelos Kratimenos, Yi Fan Li, Milan Manoj, Ethan Sanchez, Sumukh Shrote, Camillo Jose Taylor, Daniel A. Hashimoto, Eric Eaton
Organizations: University of Pennsylvania, Philadelphia, PA, USA · The Hong Kong Polytechnic University (PolyU), Hung Hom, Hong Kong
Advances in diffusion-based generative models have motivated the use of synthetic image generation to alleviate data scarcity in vision tasks. While this strategy has shown promise in natural image benchmarks such as ImageNet, its effectiveness in sparse, high-variance real-world domains remains unclear. In this work, we focus on domains where images differ substantially from common image datasets and additional data are expensive to obtain. Against non-generative data augmentation baselines, we evaluate the downstream classifier performance improvements yielded by two schools of generative sparse data extension: distribution modeling and sample perturbation. Across five trauma classification tasks using subject-wise train--validation splits, no generative approach consistently outperforms a strong non-generative baseline. Feature-space analysis reveals recurring failure modes: memorization or collapse, distributional drift, and generation of visually plausible but simplified canonical instances that are easier to classify than real data.
Figures & tables
Figure 1: Distribution of trauma labels across classification tasks. Torso trauma, head trauma, and severe hemorrhage are binary presence–absence tasks, while extremity trauma additionally distinguishes wounds and amputations.
Figure 2: Example images from realistic medical trauma simulations, including medical manikins (left images) and de-identified actors in moulage (right images) - (UPenn IRB #856195, USAISR Protocol #M-11034).
Figure 3: Generative Model Outputs. Compared to the real images in Figure 2 , many of the distribution model images are unrealistically clean regarding lack of adverse lighting, dirt and/or grime obscuring the wound, and potentially suboptimal camera angles, especially from GPT.
Method
Sev. Hem.
Head
Torso
Upper Ext.
Lower Ext.
Real Data Only
50.00 ± 0.00
50.00 ± 0.00
50.00 ± 0.00
33.33 ± 0.00
33.33 ± 0.00
Image Dup
63.11 ± 0.00
44.15 ± 0.00
67.73 ± 0.00
39.37 ± 0.00
60.81 ± 0.00
AugMix (Baseline)
63.38 ± 1.62
48.61 ± 0.45
62.45 ± 0.30
37.78 ± 0.76
66.56 ± 1.26
IP-Adapter
56.00 ± 2.14
49.37 ± 0.79
55.36 ± 0.97
42.87 ± 0.67
46.13 ± 2.44
Img2Img
49.75 ± 0.59
54.04 ± 0.74
60.55 ± 1.01
40.32 ± 1.09
47.16 ± 0.49
DB Img2Img
57.76 ± 0.71
51.36 ± 1.24
63.69 ± 0.19
41.11 ± 0.67
57.06 ± 1.51
Table 1: Macro-recall (%) with standard error.
Figure 4: MMD² between each synthetic dataset and the real data versus the average percent gain in classifier recall over the AugMix baseline. Whiskers denote standard error. Sample-perturbation methods tend to remain closer to the real data distribution and yield larger gains, while distribution-modeling approaches lie farther away. Overall, greater distributional similarity correlates with larger performance improvements
Figure 5: t-SNE plots of Generated Images Relative to Real Data - Sample Perturbation Methods tend to have lower MMD2 and fill in gaps between existing real data while the Distribution Modeling Methods tend to spawn their own separate cluster, resulting in higher MMD2
Method
Hemorrhage
Head
Torso
Upper Ext.
Lower Ext.
Diffusion
-4.6
+0.1
-4.6
-5.1
-9.5
DreamBooth
-8.2
+0.1
-2.8
-2.6
+2.3
GPT
-15.2
-7.9
-23.1
-26.9
+4.7
IP-Adapter
+2.1
+32.6
+6.8
-3.6
-4.2
SD Img2Img
-9.0
+8.0
+7.8
-9.7
+21.8
SD Img2Img + DB
+1.2
+9.3
+8.9
-0.9
+2.7
Table 2: Absolute percentage-point change in macro-recall relative to the AugMix baseline for end-to-end ResNet classifiers trained with different synthetic augmentation pipelines.
Method
1:1
1:2
1:5
1:10
GPT
56.6
59.3
55.5
51.2
IP-Adapter
62.1
61.8
61.2
58.0
SD Img2Img
59.6
57.6
60.6
58.2
Table 3: Mean macro-recall (%) across the five trauma classification tasks under different real-to-synthetic training ratios. Bold indicates the best ratio for each generation method.
Figure 6: DINOv2 embeddings, projected onto the top two principal components of the real training data, show that synthetic exemplars are more easily separable than real images, requiring simpler classification boundaries, as illustrated by a SVM with an RBF kernel
Augmentation Method
Macro-recall (%)
Real Data Only
77.48
AugMix (baseline)
80.46
DreamBooth (Direct Gen)
77.20
Stable Diffusion (FT)
75.41
Img2Img
77.79
Img2Img + DreamBooth
76.62
Table 4: Macro-recall on weld classification with synthetic augmentation.
Data Generation Method
Hemo
Head
Torso
Upper Ext
Lower Ext
DreamBooth
-7.02%
-2.25%
-9.44%
+17.57%
-15.94%
Img2Img
+5.31%
+3.94%
+1.12%
+23.89%
-9.37%
Img2Img + DreamBooth
+1.63%
+9.06%
-4.41%
-1.61%
-4.41%
IP-Adapter
+4.93%
+4.37%
-4.33%
+17.69%
-4.22%
GPT
-6.25%
+4.65%
-7.36%
-14.17%
-5.41%
Table 5: Performance gain relative to AugMix when exemplar synthetic data are mixed with real training data across injury categories. Positive values indicate improvement over AugMix; negative values (red) show that adding synthetic data hurts performance.
Figure 7: Examples of the Synthetic Generation Outputs for the Welding Data
Class imbalance is a persistent challenge in visual recognition, particularly in safety-critical domains where collecting positive examples is expensive and rare events are inherently underrepresented. We propose a lightweight synthetic data augmentation pipeline that fine-tunes a LoRA adapter on as few as 20-50 real images of a rare class and uses a pretrained diffusion model to generate synthetic samples for training. We systematically vary the synthetic-to-real ratio and evaluate the approach across two structurally different domains: chest X-ray pathology classification (NIH ChestX-ray14) and industrial surface crack detection (Magnetic Tile Defect dataset). All evaluations are performed on held-out sets of real images only. Across both domains, synthetic augmentation consistently improves rare-class recall and F1 compared to training with real data alone. Performance improves with moderate synthetic augmentation and shows diminishing returns as the synthetic ratio increases. These results suggest that LoRA-adapted diffusion models provide a simple and scalable mechanism for augmenting rare classes, enabling effective learning in data-scarce scenarios across heterogeneous visual domains.
Daniil Dushenev, Nazariy Karpov, Daniil Zinovjev +2
National University of Science and Technology MISIS, Moscow, Russia
Recent generative models can produce high-quality synthetic images, offering scalable training training data for data-hungry models. Existing approaches to exploiting this potential typically involve 1) training or fine-tuning generators, or 2) using lightweight post-hoc adaptation like prompt engineering or inference-time guidance, making them generator-specific and expertise-intensive. We study a complementary question: given a fixed pool of generated images, can downstream utility be improved purely by selecting an informative subset? The answer is yes. We show that effective selection must counter a structural bias of modern generators: they tend to over-produce canonical modes of each class while underrepresenting intra-class variation. Building on this insight, we split each real class into a canonical Homogeneous (HO) subset and a non-redundant Heterogeneous (HE) subset, then score synthetic images by a fidelity-diversity criterion that rewards semantic alignment while penalizing canonical redundancy. The method is generator-agnostic and requires no retraining. Across multiple benchmarks, it consistently outperforms state-of-the-art data selection baselines and matches the real-data performance with up to 40% fewer synthetic samples. The same criterion remains effective when applied on top of stronger task-tuned generators, with gains on both classification and segmentation tasks. Post-generation selection is therefore not a substitute for better generators, but a complementary mechanism for improving the utility of synthetic data.
Disheng Liu, Tuo Liang, Chaoda Song +1
Department of Computer and Data Sciences Case Western Reserve University Cleveland, OH, USA
Generative Adversarial Networks (GANs) can help overcome data scarcity in computer vision tasks by generating additional training samples. In this work, we explore generative data augmentation in two low-resource domains: Bangla handwritten character recognition and chest X-ray image analysis. We use DCGAN-based models trained on 64x64 images to generate synthetic samples and evaluate their quality using Inception Score (IS), Fréchet Inception Distance (FID), and visualization methods such as t-SNE and UMAP. To measure practical usefulness, we train image classifiers using real data and a combination of real and synthetic data. Experimental results show that synthetic augmentation improves data diversity and consistently increases classification performance in limited-data settings. We also investigate training stability techniques, including gradient penalty and spectral normalization, and perform ablation studies on synthetic-to-real data ratios and sample filtering strategies. In addition, we discuss challenges related to medical image evaluation, dataset licensing, and privacy concerns of synthetic data. Our approach is simple, reproducible, and provides a strong baseline for generative augmentation in resource-constrained imaging applications.
Md. Sohanuzzaman Soad, Mahady Al Hady, S M Rafiuddin Rifat +1
Department of Computer Science and Engineering University of Asia Pacific Dhaka, Bangladesh