CAITLYN: Can LLM Agents Autonomously Synthesize Defenses against Emerging Injection Attacks?

Prompt injection remains a critical threat to LLM agents, yet existing defenses treat each task as a self-contained problem, independent of previous encounters. In practice, user requests are often underspecified: they describe the desired outcome without fully specifying acceptable behavior. An injection can exploit this ambiguity, causing the agent to complete the task in a way the user would reject. As the user's expectations become clearer through concrete cases, a defense should learn from each encounter and apply what it learns to the next. Inspired by adaptive immunity, we propose AgentAntibody, which equips LLM agents with a self-evolving immune system against prompt injection. AgentAntibody represents its evolving understanding of the user's security boundary as a persistent library of antibodies. At runtime, the library recognizes threats to this boundary and mounts corresponding immune responses. Across encounters, it evolves to strengthen the agent's immunity to future attacks. Extensive experiments across three benchmarks and four backbone LLMs show that, by learning the user's boundary through experience, AgentAntibody outperforms existing defenses in preventing harmful actions while preserving legitimate task completion, even when the harmful and legitimate actions are both compatible with the stated task.

Large Language Model (LLM) agents are susceptible to Indirect Prompt Injection (IPI) attacks, where malicious instructions in retrieved content hijack the agent's execution. Existing defenses typically rely on strict filtering or refusal mechanisms, which suffer from a critical limitation: over-refusal, prematurely terminating valid agentic workflows. We propose ICON, a probing-to-mitigation framework that neutralizes attacks while preserving task continuity. Our key insight is that IPI attacks leave distinct over-focusing signatures in the latent space. We introduce a Latent Space Trace Prober to detect attacks based on high intensity scores. Subsequently, a Mitigating Rectifier performs surgical attention steering that selectively manipulate adversarial query key dependencies while amplifying task relevant elements to restore the LLM's functional trajectory. Extensive evaluations on multiple backbones show that ICON achieves a competitive 0.4% ASR, matching commercial grade detectors, while yielding a over 50% task utility gain. Furthermore, ICON demonstrates robust Out of Distribution(OOD) generalization and extends effectively to multi-modal agents, establishing a superior balance between security and efficiency.

Large language model (LLM) agents increasingly rely on external tools and retrieval systems to autonomously complete complex tasks. However, this design exposes agents to indirect prompt injection (IPI), where attacker-controlled context embedded in tool outputs or retrieved content silently steers agent actions away from user intent. Unlike prompt-based attacks, IPI unfolds over multi-turn trajectories, making malicious control difficult to disentangle from legitimate task execution. Existing inference-time defenses primarily rely on heuristic detection and conservative blocking of high-risk actions, which can prematurely terminate workflows or broadly suppress tool usage under ambiguous multi-turn scenarios. We propose AgentSentry, a novel inference-time detection and mitigation framework for tool-augmented LLM agents. To the best of our knowledge, AgentSentry is the first inference-time defense to model multi-turn IPI as a temporal causal takeover. It localizes takeover points via controlled counterfactual re-executions at tool-return boundaries and enables safe continuation through causally guided context purification that removes attack-induced deviations while preserving task-relevant evidence. We evaluate AgentSentry on the AgentDojo benchmark across four task suites, three IPI attack families, and multiple black-box LLMs. AgentSentry eliminates successful attacks and maintains strong utility under attack, achieving an average Utility Under Attack (UA) of 74.55 %, improving UA by 20.8 to 33.6 percentage points over the strongest baselines without degrading benign performance.