Deploying DeepSeek 175B Locally on a Single Consumer-Grade RTX 4060 Laptop with 32GB RAM for 200k-Scale Protein-Ligand Virtual Screening

Large language model (LLM) training today runs on clusters spanning thousands of GPUs. While this scale enables rapid model advances, developing, debugging, and performance-tuning the training framework inevitably becomes complex and costly. This is because engineers often need to reproduce production behaviors to diagnose failures or evaluate optimizations, thereby demanding frequent and even exclusive access to production-scale clusters -- which becomes increasingly hard given that the majority of GPUs are already committed to production workloads. Simulation relies on complex performance models that are difficult to maintain, and downscaled experiments often fail to capture scale-dependent behaviors. We present PrismLLM to decouple large-scale execution from the need to access large clusters, enabling engineers to run and observe ranks of interest under faithful large-scale behavior using only a few GPUs. PrismLLM constructs a high-fidelity execution graph via a slicing-based approach that captures computation, communication, and dependencies of the target scale. Then, PrismLLM performs hybrid emulation where selected ranks execute the original program while the remaining ranks are replayed as virtual participants. Experiments on large-scale LLM training workloads show that PrismLLM accurately reproduces performance and memory behavior, achieving only 0.58% average error in iteration time and less than 0.01% error in peak GPU memory usage. PrismLLM can emulate clusters of up to 8192 GPUs using fewer than 1% of the physical GPUs required by the original deployment.

We present AMix-2, a protein-text foundation model that establishes protein as a native modality in large language models (LLMs), unifying protein understanding and sequence design within a single foundation model. AMix-2 is built upon two key ideas: (1) a unified protein-text formulation that embeds natural language and protein sequence in a shared token space, enabling one model to perform biological reasoning and conditional design instead of separate downstream task-specialized models; and (2) a block-wise diffusion language modeling backbone that combines causal generation across blocks with bidirectional context and iterative refinement within blocks. This scheme better matches the intrinsic nature of proteins than a strict left-to-right factorization. To evaluate protein foundation models under realistic generalization settings, we further introduce ProteinArena, a comprehensive benchmark with time-aware and homology-aware protocols across various understanding and design tasks, and with baselines covering classical bioinformatics tools, protein-specialized models and LLMs. On ProteinArena, AMix-2 outperforms frontier LLMs and demonstrates competitive performance to task-specific protein models. Controlled experiments further show that the diffusion-based paradigm generally surpasses its autoregressive counterpart, highlighting the advantage of flexible generation order for protein sequences. We release both AMix-2 and ProteinArena to facilitate open research in protein foundation models.

Lightweight large language models (LLMs) are increasingly being deployed locally on personal computers and are expected to play a growing role in resource-constrained edge and mobile environments. In such settings, energy consumption, execution time, and memory usage directly affect practical usability, yet existing evaluations of LLM efficiency largely rely on proxy descriptors such as parameter count or FLOPs, often decoupled from task precision. This paper introduces a PTME-based experimental framework for the precision-aware profiling of lightweight LLM inference, jointly measuring Precision, execution Time, peak Memory usage, and Energy consumption through direct hardware-level measurements. The methodology is applied to a representative set of lightweight LLMs executed locally under edge-class resource envelopes on a controlled desktop platform, using benchmarks spanning code generation, mathematical reasoning, and multi-task understanding. We find that static proxy descriptors approximate inference cost well but fail to predict precision. Tightening the resource envelope increases cost without affecting precision, amplifying execution time more strongly than energy and penalizing larger models the most. Moreover, no single model dominates across all PTME dimensions, and a Pareto analysis reveals non-dominated configurations that would be hidden by accuracy-only or efficiency-only assessments, providing practical guidance for selecting models under different resource envelopes. These results show that selecting lightweight LLMs by size, FLOPs, latency, or accuracy alone can select the wrong deployment candidate; PTME profiling exposes configurations that preserve useful accuracy at lower physical cost.