Authors: Moritz A. Knolle, Martin J. Menten, Laurin Lux, Mélanie Roschewitz, Emma A. M. Stanley, Georgios Kaissis, Daniel Rueckert, Ben Glocker
Organizations: Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Germany. · Munich Center for Machine Learning, Germany. · Department of Computing, Imperial College London, United Kingdom. · Hasso Plattner Institute, Germany.
Medical AI models hold immense potential to improve patient outcomes, but they are also known to unintentionally memorise individual records from their training datasets. While such memorisation has been linked to targeted privacy attacks, its consequences for clinical deployment, where patients may be assessed by a model that saw their historical data during training, remain poorly understood. Here we show that predictions on a patient's unseen future data can change significantly if a model observed that same patient's anonymised historical data during training, a phenomenon we term "memorisation bias". We demonstrate that this bias exists across diverse data modalities and model architectures, and over prolonged time spans: in some cases, memorisation bias persists on future records acquired decades after the historical records used for training. Moreover, in simulated prospective deployment, memorisation bias has asymmetric effects on the diagnostic accuracy of returning data contributors. When a patient returned with a de novo condition absent from their historical records in the training dataset, diagnostic sensitivity decreased significantly compared to an otherwise identical model not trained on their historical data. Conversely, when their health state was unchanged, both sensitivity and specificity were significantly inflated. Our findings reveal a previously uncharacterised risk in medical AI that arises when a model is deployed on patients who contributed to its training data. This exposes a shortcoming of current model development practice: the de-identification measures designed to protect patients' privacy make it difficult to identify returning contributors and exclude them from the AI-assisted interpretation of their own future data. Mitigating memorisation risks may thus require changes to current model training and deployment protocols.
Medical language models (LMs) can memorize and reproduce protected health information, but privacy evaluations often focus on recovery of training text rather than disclosure under realistic threat models. We introduce a clinically grounded framework that evaluates leakage along a graded axis of adversarial access, ranging from publicly inferable demographics to leaked note fragments. At each tier, we measure verbatim memorization of patient-specific text and semantic leakage of sensitive diagnoses. Applying the framework to an LM pretrained on 378k clinical notes, we find that routine encounter metadata (i.e. name, date of birth, provider, practice, visit date) elicits high rates of verbatim memorization across a patient's timeline and sensitive-diagnosis recovery (AUROC 0.91 for abortion, 0.81 for HIV). At the same time, exact-match memorization can overstate disclosure: 36% of memorized tokens reflect templated documentation. Our work highlights the risks of training on longitudinal clinical data, providing a practical framework for contextual privacy evaluation of medical LMs.
While deep generative models offer new opportunities for medical image synthesis and data sharing, their ability to memorize and reproduce training samples raises serious concerns about patient confidentiality. Detecting such memorization at scale remains challenging: traditional pixel-based metrics are sensitive to generation artifacts, whereas generic embedding-based metrics often lack the anatomical sensitivity required for medical data. To address this challenge, we introduce DeepSSIM++, a self-supervised similarity metric for scalable memorization auditing in medical generative models. By leveraging multi-scale feature aggregation and anatomy-preserving augmentations, DeepSSIM++ learns an embedding space where cosine similarity approximates the Structural Similarity Index (SSIM), eliminating the need for exact pixel-level registration. Compared with state-of-the-art baselines, DeepSSIM++ achieves an average Macro F1 improvement of 33 percentage points under ideal alignment and 46 percentage points under realistic spatial and intensity perturbations. Furthermore, it accelerates large-scale similarity computation by several orders of magnitude compared with analytical SSIM. By combining anatomical sensitivity and computational efficiency, DeepSSIM++ provides an open-source tool for scalable memorization auditing in medical generative AI. Code and data are publicly available at: https://github.com/brAIn-science/DeepSSIM.
Antonio Scardace, Francesco Guarnera, Sebastiano Battiato +1
Medical knowledge is continuously evolving. This creates a need to update or selectively forget information encoded in already-trained medical LLMs. Machine unlearning aims to remove the influence of specific training data from a model without full retraining. Yet, existing unlearning benchmarks rely on synthetic or small-scale general data, leaving clinical unlearning understudied. We introduce AMNESIA, the first large-scale, open source benchmark for medical unlearning, with 70,560 question-answer pairs from 8,820 patient notes across 11 disease categories. AMNESIA includes both factual questions testing direct recall and reasoning questions testing clinical inference. We use it to evaluate four widely used unlearning methods at both random patient and disease-level, and introduce a new metric for detecting leakage of medical terminology. We show that unlearning individual patients erodes knowledge of others with the same condition, calling for methods that can better separate patients from shared clinical knowledge.