Initialization and Stopping Tolerance in CPU Dermoscopic Segmentation

Contour initialization and numerical stopping can jointly affect the evaluation of active-contour segmentation. We examine their interaction using the open-source scikit-image Chan-Vese implementation on a resized ISIC 2017 mirror. A fixed development set of 100 images selects a common input channel; all 600 images in the repository's held-out partition are then evaluated. Otsu thresholding is compared with checkerboard-, disk-, and Otsu-initialized contours under default and tighter level-set tolerances. At the default tolerance, Otsu initialization increases mean image Dice from 0.6011 to 0.6660 relative to checkerboard initialization, a paired difference of 0.0649 (95% image-bootstrap interval [0.0452, 0.0860]). Otsu thresholding alone achieves 0.6897. The default disk initializer stops after one iteration on 471 images. Tightening the tolerance reduces the Otsu-seed advantage over checkerboard initialization to 0.0197, with most runs reaching the 500-iteration limit. The default-tolerance advantage also reverses between small- and large-lesion strata. These findings show that an improvement over a generic initializer can coexist with deterioration relative to the threshold baseline. Evaluations should retain the unrefined mask as a comparator and report the initial-field definition, stopping tolerance, and observed iteration counts together.