Diff-RF: Mutually Reinforced Image Registration and Fusion via Degradation-Aware Learning

Image registration and fusion aim to establish spatial correspondences from misaligned multi-modal source images, and integrate complementary information. However, in real-world imaging scenarios, source images are often affected by complex and diverse degradations, such as low illumination, noise, etc., which severely hinder the effectiveness of registration and fusion. To address this issue, we propose a mutually reinforced image registration and fusion diffusion framework via degradation-aware learning, termed Diff-RF. It explores the intrinsic coupling between registration-fusion and information restoration in the degradation conditions, enabling high-quality fusion of unregistered images under complex degradation conditions. First, the intra-modal restoration module is designed to alleviate modality-specific degradations by leveraging information within each modality, thereby providing more reliable structural representations for registration and facilitating subsequent cross-modal fusion. Second, we develop a cross-modal diffusion registration and fusion module that establishes bidirectional interaction between registration and fusion. By integrating fusion-derived visual cues and correspondence-based geometric conditions into the diffusion process, the proposed framework progressively refines spatial alignment and exploits cross-modal complementary information to achieve collaborative enhancement. Rather than treating them as independent components, degradation-aware information restoration and the collaborative optimization of registration and fusion are tightly coupled, achieving overall performance improvements. Extensive experiments on multiple extended datasets demonstrate that Diff-RF achieves superior registration accuracy and fusion quality under various degraded scenarios, exhibiting strong robustness and generalization ability.