Re-ranking and Late Interaction Drive Retrieval Quality: A Controlled Comparison of RAG Strategies for Scientific Question Answering

We introduce SciRet, a compute-aware empirical study of retrieval-augmented generation for scientific question answering over CORD-19. Rather than proposing a new model, we evaluate a fixed scientific RAG pipeline across three corpus scales: 1,034 chunks (1K papers), 5,160 chunks (5K papers), and 15,480 chunks (15K papers). The pipeline combines sentence-window chunking, BM25, BGE-M3 dense retrieval, reciprocal rank fusion, optional cross-encoder reranking, and grounded answer generation. Across these settings, hybrid retrieval is more robust than either sparse-only or dense-only retrieval in our setting, reaching Recall@10 of 1.000 at 1K and 15K. In contrast, an MS MARCO-trained cross-encoder reranker reduces precision on the scientific corpus, suggesting that domain mismatch can outweigh the benefits of stronger query-passage interaction. Generation faithfulness measured with RAGAS increases with corpus scale in our setup. Retrieval evaluation uses pseudo-relevance labels derived from the hybrid system, so we treat the results as controlled comparative evidence rather than a benchmark claim. We release code, indexes, and evaluation outputs to support replication and follow-up studies.

Retrieval-Augmented Generation (RAG) offers a well-established path to grounding large language model (LLM) outputs in external knowledge, yet the question of which retrieval strategy works best in a high-stakes domain such as biomedicine has not received the controlled, multi-metric treatment it deserves. This paper presents a systematic empirical comparison of five retrieval strategies -- Dense Vector Search, Hybrid BM25 + Dense retrieval, Cross-Encoder Reranking, Multi-Query Expansion, and Maximal Marginal Relevance (MMR) -- within a biomedical question-answering RAG pipeline. All strategies share a fixed generation model (GPT-4o-mini), a common vector store (ChromaDB), and OpenAI's text-embedding-3-small embeddings, ensuring that observed differences are attributable to retrieval alone. Evaluation is conducted on 250 question-answer pairs drawn from a preprocessed subset of the BioASQ benchmark (rag-mini-bioasq) using four DeepEval metrics: contextual precision, contextual recall, faithfulness, and answer relevancy, each reported with 95% confidence intervals. A no-context ablation is included as a lower bound. Cross-Encoder Reranking achieves the best composite score (0.827) and highest contextual precision (0.852), confirming that query-document interaction yields measurable retrieval gains. Multi-Query Expansion, despite its recall-oriented design, produces the weakest contextual precision (0.671), suggesting naive query diversification introduces retrieval noise. MMR sacrifices answer relevancy for diversity, while the Dense baseline (composite 0.822) falls within 0.005 points of the top strategy. All RAG conditions dramatically outperform the no-context ablation on answer relevancy (0.658-0.701 vs. 0.287), confirming the practical value of retrieval. The full pipeline, hyperparameters, and evaluation code are publicly available.

Retrieval-augmented generation (RAG) systems typically rely on a single retriever and a single set of hyperparameters, despite facing highly heterogeneous queries that range from simple factoid questions to complex multi-hop reasoning. We propose a method that automatically selects a small, diverse subset of retrievers (a portfolio) from a large pool of candidates, to cover different regions of the target query distribution. We formalize this setting via an expected best-of-$k$ objective over the query distribution and show that it admits an efficient portfolio construction algorithm with near-optimal guarantees. Across multiple QA benchmarks, our learned portfolios and router pipeline consistently outperform single-retriever and naive multi-retriever baselines on both retrieval metrics and answer quality. In addition, compared to inference-time hyperparameter tuning approaches, fixed portfolios enable parallel retrieval and LLM calls, achieving comparable (and sometimes better) accuracy with substantially lower latency and token cost.