Defining and Categorising Human-AI Interactions in Clinical Trials: A Multidimensional Human-AI Classification Approach

This paper examines records retrieved from the ClinicalTrials.gov registry to characterize temporal trends in AI terminology and the geographical distribution of AI trials. The work also reports on an exploratory hybrid human-AI approach to analyzing human-AI interaction trends in registered clinical trials. The hybrid workflow comprised a frontier generative AI model (GPT-5.5) and human review to screen and categorize records returned by an AI-focused search. The findings indicate a marked increase in AI-related trials over time, with recent growth in references to machine learning, deep learning, chatbots, GPTs, and large language models. Geographically, China and the United States accounted for the largest numbers of AI-related trials, with notable recent increases in several other countries including Italy, France, Spain, the UK and Turkey (Türkiye). In a random sample of 100 records, human and AI classifiers showed good agreement in identifying studies not substantively using AI, but lower agreement in classifying human-AI interaction, particularly where health professional interaction was ambiguous or insufficiently described. Overall, the results suggest that hybrid human-AI screening of clinical trial records is potentially viable, but clearer trial reporting and more precise interaction definitions will benefit the process.

The growing use of Large Language Models (LLMs) in education, software engineering, academic writing, and technical documentation raises a key question: how can we evaluate not only AI-assisted outputs, but also the interaction process that produced them? Current debates often focus on detecting whether a final artifact was generated by AI, while overlooking the conversation history that reveals human direction, AI contribution, corrections, validation, and traceability. This paper introduces LLMography, a framework for transforming Human-AI conversations into measurable indicators of provenance, human contribution, AI dependency, reproducibility, and auditability. By analogy with bibliography and webography, LLMography documents the dynamic trajectory of interaction between a human and a Large Language Model as a structured trace of Human-AI co-production. We present a prototype that analyzes Human-AI conversation traces and generates KPI reports including Prompt Quality Score, Human Direction Score, AI Dependency Level, Auditability Score, Final Output Traceability, Privacy Risk Level, and a recommended LLMography label. A preliminary exploratory evaluation was conducted on 19 anonymized audit reports from engineering students. Most interactions were classified as Human-AI co-produced, with average scores of 86.8/100 for Human Direction, 81.9/100 for Prompt Quality, 72.8/100 for Auditability, and 77.1/100 for Final Output Traceability. The paper also applies LLMography to its own writing process, classified as human-originated, human-directed, AI-assisted co-production. The findings suggest that AI transparency should move beyond output detection toward documenting the history of interaction.

Human-AI teaming has received increasing attention in the literature. However, the range of studies conducted in multiple domains make it difficult to understand what types of teams are being studied, and in what ways are they similar/different from one another. In this study, we analyse 53 papers on human-AI teams and categorise them into five main clusters based on psychological taxonomies of teaming; AI Assistant, Ad-hoc Dependency, Ad-hoc Forced Dependency, Paired Equanimity, and Group Equanimity. Each cluster represents a unique combination of holistic team-level characteristics, indicating there are multiple disparate team types studied under the same definition. In turn, this raises the question of whether insights are truly transferable between papers. We conclude with guidance on how to identify the types of human-AI teams studied, a checklist for reporting a human-AI team in research work, and ways in which the field can be further synthesised.