ReMaD: Tuning-free Domain Adaptation for Classification and Out-of-Distribution Detection

Out-of-distribution (OOD) detection identifies test samples that fall outside a model's training distribution, a capability critical for safe deployment in high-stakes applications. Standard OOD detectors are trained on a specific in-distribution (ID) dataset and detect deviations from that single domain. In contrast, we study few-shot cross-domain OOD detection: given a \emph{single} pre-trained model, can we perform OOD detection on \emph{arbitrary} new ID-OOD task pairs using only a handful of ID samples at inference time, with no additional training? We propose \textbf{UFCOD}, a unified framework that achieves this goal through information-geometric analysis of diffusion trajectories. Our key insight is that diffusion noise predictions are score functions (gradients of log-density), and we extract two energy features: \emph{Path Energy} (integrated score magnitude) and \emph{Dynamics Energy} (score smoothness), that form a discrete Sobolev norm capturing how samples interact with the learned diffusion process. The central contribution is a \textbf{train-once, deploy-anywhere} paradigm: a diffusion model trained on a single dataset (e.g., CelebA) serves as a universal feature extractor for OOD detection across semantically unrelated domains (e.g., CIFAR-10, SVHN, Textures). At deployment, each new task requires only $\sim$100 unlabeled ID samples for inference: no retraining, no fine-tuning, no task-specific adaptation. Using 100 ID samples per task, UFCOD achieves 93.7% average AUROC across 12 cross-domain benchmarks, competitive with methods trained on 50k--163k samples, demonstrating $\sim$500$\times$ improvement in sample efficiency. See our code in https://github.com/lili0415/UFCOD.

Foundation models provide highly descriptive representations for medical images, yet their reliability degrades under distribution shifts arising from changes in patients, devices, or acquisition conditions. Reliable out-of-distribution (OOD) detection is therefore essential for safe deployment. Recent post-hoc detectors efficiently exploit frozen embeddings (e.g., kNN), whereas reconstruction-based OOD detection in latent feature space has seen limited adoption due to inconsistent performance. In this work, we show that the limitation of reconstruction-based methods in latent space does not stem from poor reconstruction quality, but from how reconstruction errors are scored. Standard L2 residual norms collapse the anisotropic residual structure, thereby suppressing informative deviations. To address this limitation, we introduce MaRS (Mahalanobis Residual Scoring), a label-free OOD detector that learns an in-distribution manifold using a lightweight autoencoder and measures deviation via a Mahalanobis distance on reconstruction residuals, yielding variance-aware OOD scores. Across three imaging modalities, multiple types of distribution shift, and different model families and scales, MaRS outperforms established confidence-, distance-, and reconstruction-based baselines, while remaining fully post-hoc and lightweight. The code is available at https://github.com/francescodisalvo05/mars.

Out-of-distribution (OOD) detection is essential for deploying machine learning models in open-world and safety-critical scenarios, where test inputs may deviate from the training distribution and overconfident predictions on unknown samples can lead to unreliable decisions. Outlier Exposure (OE) has emerged as a promising OOD detection paradigm by introducing auxiliary outliers during training to enlarge the margin between in-distribution (ID) and OOD samples. Existing OE-based methods typically enlarge this margin by employing uniform labels to maximize the entropy of OOD samples over ID categories. However, we theoretically show that uniform labels inevitably disregard the relations between OOD samples and ID categories, termed the over-softening effect, leading to a suboptimal margin bound. Our theoretical analysis further reveals that explicitly exploiting such relations can instead yield improved OOD detection performance. Motivated by this insight, we propose \underline{A}daptive Confidence \underline{OE} (AOE), a simple yet effective method that leverages temperature scaling to recalibrate outlier labels. Specifically, AOE generates adaptive soft targets from temperature-scaled model predictions for OOD samples, where the learnable temperature smooths the prediction distribution without fully erasing class-wise relational information. By supervising OOD samples with these adaptive soft targets, AOE preserves the semantic proximity between OOD samples and ID categories while encouraging the softened targets to approach a high-entropy distribution, thereby suppressing overconfident OOD predictions and enlarging the separation margin. Extensive experiments across diverse benchmarks demonstrate the effectiveness of AOE.