Motif Scaffolding

Motif scaffolding is a computational protein design approach focused on creating protein structures that incorporate specific functional motifs, crucial for developing novel enzymes and vaccines. Recent research heavily utilizes diffusion models, often enhanced with techniques like SE(3) flow matching or "floating anchor" strategies, to generate diverse and structurally realistic scaffold designs, overcoming limitations of previous methods. These advancements address the challenge of incorporating multiple motifs and producing longer, more complex protein structures, improving the success rate of *in silico* protein design and potentially accelerating the development of new biomolecules.