Extraction

Automatic extraction of retinal vascular biomarkers from color fundus images (CFI) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source Python toolbox that extracts biomarkers from CFI artery-vein segmentations. VascX starts from vessel segmentation masks, extracts their skeletons, builds undirected and directed vessel graphs, and resolves vessel segments into longer vessels. A comprehensive set of biomarkers is derived, including vascular density, central retinal equivalents (CREs), and tortuosity. Spatially localized biomarkers may be calculated over grids placed relative to the fovea and optic disc. VascX is released via GitHub and PyPI with comprehensive documentation and examples. Our test-retest reproducibility analysis on repeat imaging of the same eye by different devices shows that most VascX biomarkers have moderate to excellent agreement (ICC > 0.5), with important differences in the level of robustness of different biomarkers. Our analyses of biomarker sensitivity to image perturbations and heuristic parameter values support these differences and further characterize VascX biomarkers. Ultimately, VascX provides an explainable and easily modifiable feature-extraction toolbox that complements segmentation to produce reliable retinal vascular biomarkers. Our graph-based biomarker computation stages support reproducible, region-aware measurements suited for large-scale clinical and epidemiological research. By enabling easy extraction of existing biomarkers and rapid experimentation with new ones, VascX supports oculomics research. Its robustness and computational efficiency facilitate scalable deployment in large databases, while open-source distribution lowers barriers to adoption for ophthalmic researchers and clinicians.

Autonomous code agents built on large language models are reshaping software and AI development through tool use, long-horizon reasoning, and self-directed interaction. However, this autonomy introduces a previously unrecognized security risk: agentic interaction fundamentally expands the LLM attack surface, enabling systematic probing and recovery of hidden system prompts that guide model behavior. We identify system prompt extraction as an emergent vulnerability intrinsic to code agents and present \textbf{\textsc{JustAsk}}, a self-evolving framework that autonomously discovers effective extraction strategies through interaction alone. Unlike prior prompt-engineering or dataset-based attacks, \textsc{JustAsk} requires no handcrafted prompts, labeled supervision, or privileged access beyond standard user interaction. It formulates extraction as an online exploration problem, using Upper Confidence Bound-based strategy selection and a hierarchical skill space spanning atomic probes and high-level orchestration. These skills exploit imperfect system-instruction generalization and inherent tensions between helpfulness and safety. Evaluated on \textbf{41} black-box commercial models across multiple providers, \textsc{JustAsk} consistently achieves full or near-complete system prompt recovery, revealing recurring design- and architecture-level vulnerabilities. Our results expose system prompts as a critical yet largely unprotected attack surface in modern agent systems.

Document-level Information Extraction (DocIE) aims to produce an output template with the entities, relations, and events of interest occurring in the given document. Standard practices include prompting decoder-only LLMs using greedy decoding to avoid output variability. Rather than treating this variability as a limitation, we show that sampling can produce substantially better solutions than greedy decoding, especially when using reasoning models. We thus propose ThinkTwice, a sampling and selection framework in which the LLM generates multiple candidate templates for a given document, and a selection module chooses the most suitable one. We introduce both an unsupervised method that exploits agreement across generated outputs, and a supervised selection method using reward models trained on labeled DocIE data. To address the scarcity of golden reasoning trajectories for DocIE, we propose a rejection-sampling-based method to generate silver training data that pairs output templates with reasoning traces. Our experiments show the validity of unsupervised and supervised ThinkTwice, consistently outperforming greedy baselines and the supervised state-of-the-art.

Memory management is vital for LLM agents in long-term and personalized interactions. Most previous work studies how to retrieve and use memory, but pays less attention to how memory is extracted. We find two main limitations in existing methods. First, extraction is "ahead-of-time": the agent saves information before it knows future tasks. A single summary prompt often mixes details, events, and relations, so useful information is lost. Second, extraction is usually one-off. Without verification, errors and hallucinations may stay in memory for a long time. To address these limitations, we propose ProMem, a proactive memory extraction framework. It separates details, events, and relations, and uses different extraction strategies for each type. It also checks completeness to recover missed events and verifies facts at the atomic level to reduce hallucinations. Experiments show that ProMem improves memory completeness and QA accuracy, while keeping a good balance between quality and token cost.

We propose FDRMFL, a task-driven multimodal feature extraction framework for federated regression under non-IID data distributions. Extracting predictive features from high-dimensional multimodal inputs is particularly challenging in this setting: data cannot leave each client, local samples are scarce and heterogeneously distributed, and unsupervised dimensionality reduction discards task-relevant information while federated training introduces representation drift across communication rounds. FDRMFL addresses these challenges through a unified four-term local objective: MSE prediction loss, a correlation-based mutual information surrogate that preserves dependence between the fused representation and the continuous target, a symmetric KL penalty that aligns cross-modal latent distributions before fusion, and an InfoNCE-style contrastive loss that anchors local representations to the global consensus. Experiments on three synthetic and two real-world near-infrared spectroscopy datasets under non-IID federated partitions, with comprehensive ablation and sensitivity analyses, demonstrate that each component contributes to the framework's effectiveness. FDRMFL reduces mean MSE by 33.8% relative to the best traditional baseline (PCA) and by 43.0% relative to VAE in simulation, and attains the lowest overall mean MSE among six federated algorithms including FedAvg, FedProx, MOON, SCAFFOLD, and FedBN.