Focal Loss

Infectious bovine pinkeye is a contagious ocular disease that adversely affects cattle health, welfare, and agricultural productivity. Conventional diagnosis relies primarily on clinical observation, which can be subjective, time-consuming, and difficult to implement efficiently in large herds or remote settings. This study evaluated and compared You Only Look Once (YOLO) v11 and YOLOv26 for automated bovine pinkeye classification and investigated the effects of class-balancing strategies on model performance. Five variants (n, s, m, l, and x) of each architecture were trained and evaluated using the original imbalanced dataset, Random Minority Oversampling (RMO), and an adapted Synthetic Minority Oversampling Technique (SMOTE). Both YOLOv11 and YOLOv26 demonstrated strong classification performance, although the effects of class balancing varied across model variants. For YOLOv11, RMO-s achieved an accuracy of 0.99, a macro F1-score of 0.98, and a true positive rate (TPR) of 1.00, with no false-negative classifications. RMO-m also achieved a TPR of 1.00 with no false negatives. For YOLOv26, the original l, RMO-m, and RMO-l variants each achieved an accuracy of 0.99 and a macro F1-score of 0.98, with RMO-l attaining a TPR of 1.00 and no false negatives. Overall, RMO generally provided greater improvements in minority-class detection than adapted SMOTE, whereas the strong performance of the original YOLOv26-l demonstrates that oversampling was not necessary for all model variants. These findings demonstrate the potential of YOLOv11 and YOLOv26 for automated detection of bovine pinkeye and support further evaluation for livestock health monitoring.

Multimodal embedding models encode heterogeneous inputs into a shared embedding space, enabling efficient similarity computation across modalities and tasks. Most existing methods optimize cosine-based contrastive objectives, which promote stable training but restrict semantic compatibility to angular geometry, precluding embedding norms from serving as an additional semantic signal. However, directly optimizing the more expressive dot-product similarity, which leverages both angular and norm information, underperforms cosine-based training and exhibits unstable training dynamics. We attribute this discrepancy to premature optimization-space expansion, manifested as angular--norm entanglement and directional anisotropy in the representation space and further compounded by full-parameter fine-tuning. In this paper, we propose PACE, a two-stage framework that progressively expands both the representation and trainable parameter spaces. Stage I combines cosine-based objective with low-rank adaptation to establish a reliable angular geometry within constrained optimization spaces. Stage II switches to dot-product similarity and full-parameter fine-tuning, enabling embedding directions and norms to jointly encode semantic information. We further introduce Focal Embedding Loss, a confidence-adaptive objective that downweights queries with high positive retrieval confidence while emphasizing ambiguous queries with competitive negatives. Experiments across multiple backbone scales and diverse multimodal embedding tasks consistently validate the effectiveness of PACE.

There is growing interest in adopting CLIP-style vision--language model (VLM) pretraining for mammography. However, models that directly employ the standard CLIP architecture and training objective exhibit limited zero-shot performance in clinically important tasks such as cancer, finding-type, and BI-RADS predictions. We argue that this underwhelming performance is due to neglecting two characteristics of mammography data: (1) its high-res nature, and (2) homogeneity of radiology reports, largely driven by a predominance of negative/benign findings on examinations. We propose TopKSigLIP, a VLM designed to address these two limitations through a novel architecture and learning objectives. Instead of downscaling high-res mammography images to satisfy GPU memory constraints, TopKSigLIP introduces TopK-Patch module that learns to sample a sparse set of high-res patches likely to contain lesions, sidestepping the resolution--batch size tradeoff of VLM training. The sampled patch locations additionally serve as a built-in localization tool. To address report homogeneity, we replace the contrastive loss, which falsely repels semantically similar pairs, with a Sup-sigmoid loss. Sup-sigmoid loss extends the sigmoid loss from SigLIP with soft labels derived from structured data. TopKSigLIP outperforms existing open-source mammography and general medical VLMs on both internal and external benchmarks on density assessment, BI-RADS classification, finding subtyping, and cancer prediction under zero-shot evaluation. TopKSigLIP remains competitive under linear probing despite using a significantly smaller vision encoder and smaller training batches than baselines. The TopK-Patch module additionally achieves superior lesion localization over post-hoc Grad-CAM. Code and weights are made public:https://github.com/Youngseok0001/TopKSigLIP.

A clinically useful chest X-ray system must go beyond fluent report generation: it should classify findings with tunable decision thresholds, localize them spatially, and derive the anatomical measurements upon which many diagnoses depend. Today's Vision-Language Models (VLMs) treat these as separate problems, if they address them at all, leaving a gap between what radiologists need and what generative models provide. We introduce CARE-X, a chest X-ray VLM that narrows this gap by unifying auxiliary discriminative supervision with reward-aligned generation. CARE-X augments its generative backbone with focal-loss classification and composite-loss grounding heads, co-trained alongside the language-modeling objective. This auxiliary supervision produces discriminative diagnostic predictions with tunable decision thresholds and precise spatial localization while also improving report quality, providing evidence that structured prediction and generation reinforce one another. Building on this foundation, Decoupled Clip and Dynamic Sampling Policy Optimization (DAPO) leverages task-specific reward signals for report generation, visual question answering (VQA), and spatial grounding, directly optimizing the clinical quality metrics that matter in practice. The result is state-of-the-art performance on the majority of metrics across four report-generation benchmarks, 94.0% VQA accuracy on ReXVQA (+6.0 pp over the next-best baseline), and generative spatial decoding that reaches near parity with dedicated detection heads. Separately, to address measurement-dependent diagnoses, we couple Qwen3-VL-4B-Instruct with native tool-calling capabilities for invoking deterministic measurement tools, while retaining full visual access to the image. This hybrid inference yields +43.6 pp average F1 over perception-only baselines across five measurement-dependent conditions.

Focal cortical dysplasia (FCD) type II is an important structural cause of drug-resistant focal epilepsy, but its small size, heterogeneous appearance, and subtle MRI characteristics make automated segmentation challenging. Conventional multimodal networks commonly concatenate T1-weighted (T1w) and fluid-attenuated inversion recovery (FLAIR) images, requiring subsequent layers to learn useful cross-modal relationships implicitly. We propose CRIL-U-Net, a 3D U-Net incorporating a Compact Ratio-Interaction Learning module that combines local spatial features, voxel-wise cross-modal mixing, and bidirectional ratio-inspired interactions. CRIL-U-Net was compared with a conventional 3D U-Net and an input self-attention U-Net using five-fold cross-validation on 85 FCD subjects and 25 healthy controls. Each architecture was trained independently using Dice-binary cross-entropy (Dice-BCE) and Focal Tversky-Focal (FTF) losses. With FTF, CRIL-U-Net achieved the highest mean Dice score (0.196 +/- 0.262), compared with 0.136 +/- 0.224 for the U-Net and 0.135 +/- 0.214 for the attention comparator. It produced nonzero lesion overlap in 44 of 85 cases, compared with 36 for the U-Net. Under FTF, CRIL-U-Net significantly outperformed both comparison architectures after false-discovery-rate correction. These findings suggest that compact cross-modal representation learning can improve FCD segmentation within a controlled U-Net setting when combined with an imbalance-aware objective, although the remaining zero-overlap rate of 48.2% highlights the need for further validation and methodological development.

Vision-language models (VLMs) are increasingly deployed as reasoning agents in real-world visual assessment pipelines, yet their spatial grounding remains unreliable for fine-grained, visually ambiguous targets. We study this gap in the context of automated vehicle damage assessment, where fine-grained defects such as scratches and hairline cracks occupy few pixels, produce weak gradient signal, and are easily confused with reflections and surface texture. We show that a state-of-the-art VLM (Qwen-VL) achieves strong semantic classification accuracy (87.3%) on this task but is systematically ungrounded at the spatial level: it hallucinates damage in reflective regions, misses elongated scratches entirely, and produces spatially inconsistent outputs when prompted for localization. We propose TinyDamage, a hybrid architecture that delegates spatial grounding to a dedicated multi-task segmentation model while reserving the VLM for semantic reasoning and report generation. On the segmentation side, we find that the choice of loss function has an outsized and underexplored effect on tiny-object grounding: focal loss, widely used for class imbalance, collapses tiny-damage detection to zero, while a supervised contrastive objective measurably improves damage/background separability. We integrate the segmentation model into a 7-node LangGraph agent pipeline that grounds every VLM generation step in the segmentation output, and show that this grounding reduces the report hallucination rate from 92% (text-only) and 78% (image-only) to 31% in a controlled evaluation on 100 human-verified reports. We introduce DET_l, a permissive per-category detection metric for evaluating tiny-object grounding under class imbalance, and report latency and reliability characteristics of the deployed pipeline.

Recently, 3D semantic occupancy prediction has garnered increasing attention for understanding the indoor scene. However, unlike structured outdoor environments, indoor scenes feature a high diversity of object categories that exhibit a severe long-tailed distribution, which has become a core bottleneck limiting the performance of existing models. To tackle this challenge, we propose a novel method, Group-UFD Occ, based on hierarchical semantic supervision and synergistic loss optimization. At the architectural level, we introduce a fine-grained semantic grouping strategy and design multi-scale, parallel ``main-expert'' prediction heads to guide the model in efficiently learning tail-class features through deep regularization. At the optimization level, we introduce the Unified Focal-Dice (UFD) loss. This synergistic loss function dynamically focuses on hard samples at the per-voxel level. Meanwhile, it simultaneously optimizes the geometric integrity of predicted objects from a region-based perspective. We conducted experiments on the large-scale EmbodiedScan dataset. The results demonstrate that our method yields a relative improvement of 11.38% over the baseline, with substantial accuracy gains in several critical long-tailed categories.

Enhancing classification performance in mammography remains a persistent challenge across both small curated datasets and large-scale clinical cohorts. Conventional transfer learning approaches often neglect dataset-specific characteristics, while recent neighborhood-informed methods have been restricted to narrow tasks with rigid formulations, limiting their scalability to population-level datasets. To address these challenges, we propose the Dataset-Informed Transfer Learning (DITL) framework, which integrates dataset-derived difficulty signals with neighborhood-based triplet supervision in a unified objective. DITL introduces two adaptive components: (i) Adaptive Difficulty-Weighted Cross-Entropy (A-DWCE), which assigns per-sample weights based on k-nearest neighbor label purity in a self-supervised feature space, and (ii) Adaptive Neighborhood Representation Triplet (A-NR-Triplet), which enforces intra-class compactness and inter-class separation using a learnable margin. Unlike focal loss, DITL requires no hyperparameter tuning, removes heuristic weighting and fixed margins, and incurs negligible computational overhead, yielding a robust and scalable optimization strategy. On the large-scale VinDR-Mammo dataset, DITL achieves state-of-the-art performance for whole-image breast density classification, with significant improvements across accuracy, F1-score, and AUC (p < 0.0001). Beyond large cohorts, DITL also delivers consistent, statistically significant gains on small ROI datasets (p < 0.0001). By bridging small-scale lesion analysis with large-scale density estimation, DITL establishes a clinically relevant, scalable, and generalizable framework for mammography classification, spanning the full breast cancer screening-to-diagnosis spectrum.

In picture-based agricultural insurance for smallholder farmers, missed damage detections carry substantially higher cost than false alarms: a farmer who sustained real losses receives no payout, while unnecessary expert review is operationally costly but reversible. Standard multi-class classifiers optimize global accuracy but provide no mechanism to operationalize or control this asymmetric cost structure at inference time. We propose CascadeCropNet, a two-stage cascade architecture calibrated to satisfy a target recall constraint (Rec-Damaged >= 0.95) through threshold selection. A lightweight Sentinel model performs binary health triage; samples exceeding a calibrated damage probability threshold tau are escalated to a specialist Expert model for fine-grained diagnosis. This design provides explicit, deployment-time control over the safety-efficiency trade-off without retraining. Evaluated on the Eyes on the Ground dataset (23,804 images from Kenyan smallholder maize farms), the cascade achieves Rec-Damaged = 0.974 at tau = 0.5, reducing missed damage cases by up to 54% relative to a flat baseline. Under evaluation alignment, the representational gap reduces to +0.008 F1-macro, confirming the contribution is architectural rather than representational. Under input degradation, the system prioritizes escalation over confident misclassification, reflecting error containment through architectural isolation rather than intrinsic model robustness. These results demonstrate that cascade architectures can operationalize safety-oriented decision constraints through calibrated routing in settings where reliability matters more than aggregate accuracy. These properties depend on threshold calibration and deployment conditions and do not constitute guarantees under arbitrary distribution shift.

Unified multimodal models seek a shared visual token space that supports both multimodal understanding and image generation. Discrete methods unify the interface via a shared codebook, whereas continuous pipelines often rely on two disparate representations -- semantic features (e.g., ViT) for understanding and low-level latents (e.g., VAE) for synthesis -- resulting in mismatched latent spaces. We propose Twins, a unified continuous token space formed by channel-wise concatenating ViT and VAE features on the same token grid, so the sequence length is unchanged and attention cost does not increase. However, jointly modeling Twins in a Diffusion Transformer exposes a severe optimization imbalance: the model fits the ViT component well but struggles to match the VAE latent distribution. We trace this imbalance to three sources of heterogeneity: frequency bias, intrinsic dimensionality, and condition-aligned vs condition-independent uncertainty. To address it, we adapt a focal regression objective for flow matching that upweights large-error VAE dimensions, better balancing optimization across the ViT and VAE components. On ImageNet, this yields up to 10.57 gFID gain over naive MSE loss without classifier-free guidance. Twins also performs competitively on multimodal understanding benchmarks and improves reconstruction fidelity, narrowing the gap between understanding- and generation-oriented representations.

Accurate skin lesion classification can benefit from lesion segmentation masks, but requiring masks or an auxiliary segmentation model during inference reduces clinical practicality and increases computational complexity. This work introduces Privileged Lesion-Context Relational Distillation (PLCRD), a teacher-student framework that exploits lesion masks exclusively during training while preserving image-only inference. The privileged teacher jointly analyzes the original dermoscopic image and its mask-guided lesion region to learn lesion-specific and contextual diagnostic representations. An image-only student is then trained through complementary knowledge-transfer mechanisms that convey the teacher's diagnostic distribution, lesion-focused attention, inter-lesion relational geometry, and lesion-context structure. PLCRD decomposes deep representations into lesion and contextual embeddings and transfers their relational organization through inter-lesion similarity alignment, lesion-context affinity matching, separation regularization, and class-aware relational learning. This formulation avoids direct feature matching between heterogeneous teacher and student architectures and enables the student to internalize mask-informed diagnostic structure without accessing masks at deployment. The framework was evaluated on HAM10000 using lesion-disjoint data partitioning and externally validated on ISIC 2018 without retraining. PLCRD achieved a lesion-level macro-F1 of 0.773 +/- 0.018, balanced accuracy of 0.764 +/- 0.023, and macro-AUROC of 0.976 +/- 0.002 on HAM10000, together with a macro-F1 of 0.732 +/- 0.008 on ISIC 2018. The results indicate that privileged lesion annotations can be transformed into transferable relational knowledge, yielding a practical and interpretable approach to mask-free skin lesion classification.

Deep survival models are evaluated almost exclusively by the concordance index (C-index), yet they are commonly trained using likelihood objectives such as the Cox partial likelihood, discrete-time negative log-likelihood, and DeepHit likelihood. This mismatch is usually considered acceptable because the C-index can be recomputed on validation data during training. However, for end-to-end training of high-capacity encoders on small, heavily censored oncology cohorts, frequent C-index evaluation is computationally expensive, making the loss value itself an important signal for monitoring, early stopping, and model selection. We show that likelihood losses are unreliable for this purpose and propose a value-monotone concordance loss. We prove that every strictly proper survival likelihood admits directions where the loss decreases while the C-index remains unchanged, causing the loss value to decouple from ranking performance. We then study a sigmoid concordance loss (SCL), whose value approximates one minus the C-index up to a temperature term, ensuring that lower loss corresponds to higher C-index during optimization. The loss is architecture agnostic and reduces to a convex survival ranking support vector machine for linear models. Across eighteen datasets from four modalities using a unified five-fold cross-validation protocol, SCL achieves discrimination comparable to standard likelihood losses and is the best or within one standard deviation of the best C-index. Unlike likelihood losses, SCL maintains a strong correlation between loss value and C-index during training, with rank correlations of 0.96 to 0.99 compared with -0.03 to 0.53 for likelihood losses. Calibration measured by the integrated Brier score is comparable. SCL provides a value-monotone optimization objective whose value can serve as a reliable surrogate for the C-index during expensive end-to-end training.

Mild Cognitive Impairment is a critical early stage of cognitive decline that frequently precedes Alzheimer's disease, yet its automated detection from neuropsychological drawing tests remains fundamentally constrained by data scarcity, class imbalance, and diagnostic ambiguity near clinical boundaries. Existing methodologies attempt to bypass these constraints using computationally expensive, fully fine-tuned hybrid architectures that relegate spatial explainability to a post-hoc approximation rather than an intrinsic model property. We propose a parameter-efficient framework utilizing frozen DINOv2-Small model adapted via three modality-specific learnable prompt tokens while Operating with 1.19 million trainable parameters, each token serves as a query in a shared cross-attention layer over the source image patch tokens. Crucially, spatial explainability is achieved directly through these attention maps; as a structural consequence of the architecture. Then task-conditioned embeddings fused via an attention module to quantify modality-level importance per subject. To handle boundary ambiguity, a MoCA-adapted focal loss introduced that integrates continuous cognitive scores into the training target, loss modulation, and adaptive sample weighting, strictly generalizing standard soft-label approaches. Under stratified five-fold cross-validation, the proposed architecture yields an MCI-class F1 of 0.641 and an AUC of 0.795, outperforming the computationally heavier ResViT baseline by 0.110 in MCI-class F1.

Detecting ambivalence and hesitancy (AH) in unconstrained video is challenging because the target signal is inherently ambiguous and expressed through subtle cross-modal incongruence rather than prototypical affect. We present CF-Net, a deep multimodal network submitted to the 3rd Edition of the AH Video Recognition Challenge (ABAW 11th, ECCV 2026), targeting the BAH dataset. CF-Net encodes visual, audio, and transcript streams with frozen SigLIP2, HuBERT, and DistilBERT backbones, normalises backbone features per speaker to reduce identity leakage, and fuses them via a ConflictFusion module that explicitly computes pairwise cross-modal incongruence. Training combines certainty-weighted focal loss, manifold mixup, and modality dropout; an auxiliary certainty-regression head uses ambiguity annotations to stabilise learning on genuinely borderline samples. CF-Net achieves a Macro F1 of 0.7155 on the BAH validation set and 0.7364 (AP = 0.7439) on the private challenge test set.

Medical image classifiers are often trained within one source population, yet clinical deployment requires robustness to patients whose appearance, acquisition style, and disease prevalence differ from the source cohort. Existing fairness and robustness methods often require group supervision or treat appearance variation as an undifferentiated nuisance, which is insufficient when population-correlated low-level cues and lesion evidence share edge and texture structure. We study a strict source-only cross-population setting, where external populations are unseen during optimization, validation, scheduling, hyperparameter and model selection. We propose RED-Sphere, a plug-and-play robustness framework for image classification under unseen population shifts. It estimates shortcut-sensitive nuisance responses with an edge and feature energy prior, attenuates dominant responses through residual soft gating, regularizes masked nuisance views with counterfactual-inspired consistency and separation losses, and predicts labels with normalized spherical prototypes. It favours angular semantic evidence over source-correlated activation magnitude while preserving lesion structure. Although demonstrated on 2D Scanning Laser Ophthalmoscopy (SLO) fundus classification for Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR), RED-Sphere is not tied to retinal anatomy: the same principle can be adapted with modality-specific nuisance priors wherever appearance shortcuts and semantic evidence are entangled. Under a strict White-only Harvard-FairVision protocol, RED-Sphere improves held-out macro-F1 across all 20 task and backbone comparisons, with average gains of 1.28 and 2.98 F1 points on AMD and DR. Gains in AUC and PR-AUC, visual diagnostics, ablations, and sensitivity analyses further support stronger external semantic alignment and more stable angular disease geometry.

Background: Graph neural networks improve computational prediction of polypharmacy side effects, but standard binary cross-entropy training allocates equal capacity to well-classified and difficult examples, potentially missing clinically significant interactions. We evaluated whether an asymmetric focal objective could improve multi-relational drug-drug interaction (DDI) prediction by emphasizing difficult positive interactions. Methods: ClinicalFocal loss was integrated into a relation-aware graph convolutional network using molecular fingerprints, physicochemical descriptors, and learned embeddings. The model was evaluated on TWOSIDES using five-fold cross-validation with identical experimental conditions (architecture, features, data partitions, hyperparameters, and random seeds) for ClinicalFocal loss and binary cross-entropy baseline. Results: ClinicalFocal loss increased accuracy from 0.699 to 0.892 (+19.3 percentage points) and F1 score from 0.700 to 0.894 (+19.4 percentage points). AUROC increased from 0.766 to 0.914, and AUCPR increased from 0.714 to 0.860. The false-negative rate decreased from 29.8% to 9.1%, while specificity increased from 69.6% to 87.5%. Overall classification error decreased from 30.1% to 10.8%, corresponding to a 64.1% relative reduction. Improvements were consistent across all five folds. Conclusions: Asymmetric focal optimization improved classification and ranking performance while achieving 90.9% recall for observed interaction triples, without modifying the underlying architecture. Loss-function design is a direct, tunable lever for improving graph-based DDI prediction.

Automated chest X-ray classification remains challenging due to severe class imbalance, co-occurring pathologies, and the loss of localized features in conventional architectures. To address these, we propose an explainable hierarchical multi-view ensemble framework for the robust classification of 14 thoracic pathologies. The framework employs view-specific training by independently modeling frontal and lateral radiographs using an ensemble of five complementary convolutional neural networks. Replacing global average pooling, a multi-scale feature fusion strategy augmented with Convolutional Block Attention Modules (CBAM) preserves fine-grained intermediate representations while emphasizing high-level pathology-specific semantic features. To mitigate positive-negative imbalance and varying inter-class difficulty, models are optimized using a novel hybrid objective combining Asymmetric Loss with Adaptive Focal Loss. Beyond simple probability averaging, the framework incorporates a hierarchical meta-learning strategy where test-time augmentation (TTA) predictions and cross-model uncertainty measures are integrated into Level-1 gradient-boosting meta-learners (XGBoost, LightGBM, and CatBoost), followed by Level-2 stacking with optimized alpha blending. Evaluated on a large-scale CheXpert-style dataset, the framework achieves state-of-the-art macro-average AUROC scores of 0.9319 for frontal and 0.9154 for lateral radiographs. Furthermore, comprehensive explainability analysis using seven post-hoc attribution techniques demonstrates strong anatomical consistency and clinically meaningful decision localization. By integrating architectural diversity, multi-scale attention, hierarchical meta-learning, and rigorous explainability, the proposed framework provides a transparent, highly accurate, and clinically practical computer-aided diagnosis system for thoracic disease classification.

Infrared small target detection (IRSTD) remains challenging due to tiny target size, low signal-to-noise ratio, severe foreground-background imbalance, and blurred boundaries in complex scenes. Existing methods usually rely on post-activation probability-domain supervision for discrimination, where weak targets and strong clutter may produce saturated and close probabilities, limiting weak-target discrimination. Meanwhile, blurred boundaries and halo-like predictions mainly stem from thermal diffusion, tiny target scale, boundary uncertainty, and insufficient explicit contour constraints. To address these issues, we propose Adaptive-Contrastive SLSIoU (AC-SLSIoU), a plug-and-play discriminative and shape-aware loss for IRSTD. Specifically, a Logit-Domain Margin Constraint (LDMC) is introduced to enlarge the response gap between targets and informative hard negatives in the logit space, thereby enhancing weak-target discrimination. Adaptive Boundary Suppression (ABS) applies scale-aware annular penalties to refine target contours and suppress halo-like overflow responses. In addition, False-Alarm Focal Loss assigns larger weights to high-probability negative samples, further penalizing persistent high-confidence false alarms. Without introducing extra inference overhead, the proposed method can be seamlessly integrated into existing detectors and consistently improves both detection accuracy and shape quality. Extensive experiments and cross-backbone evaluations demonstrate the effectiveness, robustness, and generalization ability of the proposed method for infrared small target detection.

Evaluation metrics are central to binary target segmentation because they determine how progress is measured, compared, and interpreted. In this paper, target denotes the task-defined positive region to be segmented rather than a generic foreground object. It may be salient, camouflaged, transparent, glass-like, mirror-like, shadow-like, lesion-like, or defined by other application-specific semantics. We treat existing metrics as compositions of modular design choices rather than isolated formulas. The proposed framework decomposes each metric into five stages covering prediction representation, target extraction, target matching, score computation, and metric reporting. We use this framework to analyze representative metrics and show how newer metrics address specific limits in earlier protocols. The stage choices keep each metric's assumptions visible. We then discuss the design space opened by the framework and its implications for task-aware evaluation protocols. Reference code is available at https://github.com/lartpang/PySODMetrics.

Automated malaria diagnosis from blood smear microscopy is a critical challenge in global health AI; in resource-limited settings, the scarcity of expert microscopists remains the primary bottleneck to timely and accurate diagnosis. Three compounding failure modes prevent reliable clinical deployment of existing deep learning systems. First, end-to-end detectors treat unannotated cells as background during training, producing recall figures that are strongly influenced by annotation completeness rather than reflecting true cell recovery. Second, Non-Maximum Suppression tends to suppress valid detections in dense smear regions where infection counts matter most. Third, existing whole-slide detection pipelines lack per-cell spatial evidence for clinical audit, despite image-level explainability methods such as Grad-CAM having been applied to malaria image classification tasks. We present MalariAI, a two-stage decoupled framework that addresses all three failure modes in a unified pipeline. Stage 1 applies an annotation-agnostic distance-transform guided watershed algorithm to isolate every cell in a full 1600x1200 blood smear image, recovering 75.95% of ground-truth cells by centroid localisation across the 120-image NIH BBBC041 test set without any ground-truth input. Stage 2 fine-tunes EfficientNet-B0 with Focal Loss (gamma = 2.0, per-class inverse-frequency weights) on 64x64 crops, achieving 98.36% overall classification accuracy with 87.5% and 75.0% per-class accuracy on the rare schizont and gametocyte stages, compared to only 24.57% and 25.95% AP for a Faster R-CNN baseline on the same classes. Grad-CAM++ heatmaps generated per detected cell provide instance-level spatial evidence for clinical audit, enabling microscopists to verify model predictions at the individual parasite level without sacrificing classification performance.

Staff absenteeism imposes substantial operational costs in high-demand work environments such as healthcare, emergency services, meat processing, construction, and courier and delivery services, where proactive workforce planning depends on reliable individual-level absence prediction. Existing regression and classification approaches share a structural limitation; they map features observed at time t to labels at the same time t, reproducing already-realised outcomes rather than predicting future events, and discard the sequential behavioural structure inherent in individual attendance histories. We propose a Time Series Classification (TSC) framework that separates historical attendance sequences from future absence labels, enabling genuinely proactive prediction. Due to the lack of public longitudinal attendance data, we construct a reproducible simulated dataset calibrated to the UCI dataset. We analyse Binary Focal Loss (BFL) and Geometric Mean (G-Mean) loss under severe class imbalance using only the imbalance ratio $ρ$. For BFL, the initial gradient ratio is $ρα/(1-α)$, implying the balanced weight $α= 1/(1+ρ) \approx 0.023$. Experiments show that performance is governed mainly by $α$, with BFL achieving specificity 0.813 and balanced accuracy 0.888, comparable to G-Mean. Unlike BFL, G-Mean adapts automatically without parameter calibration. Among three deep learning architectures evaluated, Long Short-Term Memory (LSTM), Convolutional Neural Network (CNN), and the hybrid LSTM-Fully Convolutional Network (LSTM-FCN), the LSTM-FCN delivers strong precision and specificity. Stable performance is obtained with batch sizes >= 64 and window sizes between 40-80 days, yielding balanced accuracy of approximately 80% on held-out test data.

Visual text editing aims to precisely modify text in images and videos while preserving stylistic consistency and visual realism. Despite significant advances in the image domain, video text editing remains largely unexplored: it is a localized task demanding stroke-level precision within small text regions, which compounds the challenges of cross-frame accuracy, temporal coherence, and stylistic fidelity. We introduce SteerVTE, a unified framework that \underline{\textbf{steer}}s a frozen video diffusion model to perform precise \underline{\textbf{V}}ideo \underline{\textbf{T}}ext \underline{\textbf{E}}diting through style and glyph control. Built on a frozen diffusion transformer, SteerVTE attaches a lightweight text context adapter with two complementary modules: a style encoder capturing the original text's visual attributes, and dual-granularity glyph encoders encoding the target text at both the line and character levels. To overcome the inherently weak text rendering priors of video foundation models, we further propose a glyph-aware spatial-focal loss and a three-stage progressive training curriculum that scales from image to video data. To support large-scale training, we also develop an automatic synthesis pipeline and construct SteerVTE-1M, a dataset of one million triplets spanning diverse scenes, fonts, and stylistic effects. Extensive experiments demonstrate that SteerVTE substantially outperforms existing video editing baselines across text accuracy, style consistency, and temporal coherence.

Pedestrian Attribute Recognition (PAR) is critical for video surveillance, enabling forensic search and re-identification systems. Extreme class imbalance remains a fundamental obstacle when merging PETA and PA-100K into a 109,000-image composite corpus, where minority attributes have positive sample fractions below 1%. This causes standard BCE optimization to suppress rare traits, a phenomenon we term the majority negative class cheating trap. We present a systematic ablation of Multi-Label Focal Loss hyperparameters (alpha and gamma) on a ResNet-18 backbone. A calibrated configuration (alpha=0.50, gamma=2.0) achieves a Macro F1-score of 62.32%, matching BCE baseline while preserving superior hard-example mining and convergence dynamics. Our approach uses pure loss-function engineering with zero computational overhead for edge deployment. We identify the Sparsity Wall, a hard boundary where positive sample fractions below 0.1% make global loss reweighting ineffective, requiring instance-level intervention.

Deep neural networks trained under severe class imbalance often exhibit degraded performance, typically attributed to statistical bias. In this work, we identify a complementary optimization-level pathology: inter-class gradient interference within shared representations, where gradients from majority classes suppress minority-class learning. To analyze this phenomenon, we introduce a diagnostic framework based on layer-wise gradient flow analysis and a Gradient Conflict Matrix, which quantifies interference using cosine similarity between class-specific gradients. Using this framework, we study multi-branch convolutional architectures and propose a lightweight modification, Class-Specific Branch Attention (CSBA), that enables branch-specific channel reweighting to reduce gradient coupling. This mechanism promotes implicit feature decoupling across branches while preserving architectural simplicity. Empirically, CSBA improves minority-class performance, increasing the F1 score for the Physical-Damage class from 0.261 to 0.522 under severe imbalance, while maintaining comparable overall accuracy. Validation on CIFAR-10-LT confirms that this behavior generalizes across imbalanced visual recognition settings, with Macro-F1 improving from 0.595 to 0.655. More broadly, our findings highlight the importance of considering optimization dynamics alongside statistical methods when designing architectures for imbalanced learning.

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, making early detection essential for effective treatment. Mammography is the primary screening modality; however, accurate delineation of suspicious lesions remains challenging and subject to inter-observer variability. Automated segmentation methods can assist radiologists by providing consistent and efficient lesion localization. This study presents DSU-Net, an attention-enhanced Dense Skip U-Net architecture for automated breast lesion segmentation in mammographic images. The proposed framework integrates dense skip connections and attention mechanisms to improve feature propagation, preserve spatial information, and enhance lesion boundary delineation. Experiments were conducted using the Curated Breast Imaging Subset of the Digital Database for Screening Mammography (CBIS-DDSM). To address severe foreground-background imbalance, a composite loss function combining Dice loss, focal loss, and binary cross-entropy loss was employed during training. The proposed model achieved a Dice Similarity Coefficient of 0.9421, an Intersection over Union of 0.8905, an accuracy of 0.9711, and an AUC-ROC of 0.9878 on the validation dataset. Qualitative evaluation demonstrated accurate delineation of lesions with varying sizes and morphologies, while quantitative results confirmed robust discrimination between lesion and background regions. These findings demonstrate that DSU-Net provides accurate and reliable breast lesion segmentation in mammographic images and highlights the potential of attention-guided deep learning for computer-aided breast cancer screening and diagnosis.

Real-time vision demands models that are accurate, efficient, and simple to deploy across diverse hardware. The YOLO family has become widely deployed for this reason, yet most YOLO detectors still rely on non-maximum suppression at inference, carry heavy detection heads due to Distribution Focal Loss, require long training schedules, and can leave the smallest objects without positive label assignments. We present Ultralytics YOLO26, a unified real-time vision model family that addresses these limitations through coordinated architecture and training advances. YOLO26 uses a dual-head design for native NMS-free end-to-end inference and removes DFL entirely, yielding a lighter head with unconstrained regression range. Its training pipeline combines MuSGD, a hybrid Muon-SGD optimizer adapted from large language model training; Progressive Loss, which shifts supervision toward the inference-time head; and STAL, a label assignment strategy that guarantees positive coverage for small objects. Beyond detection, YOLO26 introduces task-specific head and loss designs for instance segmentation, pose estimation, and oriented detection, producing consistent gains across tasks and scales. The family spans five scales (n/s/m/l/x) and supports detection, instance segmentation, pose estimation, classification, and oriented detection in a single pipeline, with an open-vocabulary extension, YOLOE-26, for text-, visual-, and prompt-free inference. Across all scales, YOLO26 achieves 40.9-57.5 mAP on COCO at 1.7-11.8 ms T4 TensorRT latency, advancing the accuracy-latency Pareto front over prior real-time detectors, while YOLOE-26x reaches 40.6 AP on LVIS minival under text prompting. Code and models are available at https://github.com/ultralytics/ultralytics.

Accurate classification of nuclei subtypes in histopathology images is critical for downstream tasks including tumor grading, immune infiltrate quantification, and prognosis prediction. Existing approaches rely on either convolutional or transformer-based encoders in isolation, limiting their ability to simultaneously capture fine-grained local texture and long-range spatial context. We present AMN (Adaptive Multi-Scale Nuclei Network), a dual-encoder segmentation framework that jointly leverages a Swin Transformer and a ResNet-50 feature pyramid, fused via a learned per-channel gating mechanism that dynamically weighs each encoder's contribution at every scale. AMN is trained with a multi-objective loss combining class-weighted focal loss, boundary-aware loss with positive-pixel emphasis, and a novel uncertainty-modulated classification term that suppresses overconfident erroneous predictions. Evaluated on the CoNIC benchmark across seven nuclei classes, AMN achieves a mean Dice of 0.82 and mean F1 of 0.68, with an F1 of 0.67 on the diagnostically challenging lymphocyte class. AMN outperforms eight baseline models spanning pure-CNN, pure-transformer, and recent hybrid architectures: U-Net, ResU-Net, DeepLabV3+, SegNet, ViT-Small, HmsU-Net, ConvFormer-UNet, and BEFUnet. Cross-dataset evaluation on MoNuSeg demonstrates strong generalization without retraining and validating the domain robustness of the learned representations.

Pathology foundation models (PFMs) have advanced rapidly in recent years and support training classifiers for a range of histopathology tasks. However, their robustness across hospitals remains limited: performance often degrades when training a classifier on data from one hospital and evaluating it on another target hospital. We address this challenge by fine-tuning PFMs with a local maximum mean discrepancy (LMMD) objective that applies to two settings: domain adaptation, where unlabeled target-hospital data is available, and domain generalization, where target-hospital data is unavailable at all. Experiments at both the patch- and slide-level show consistent improvements across multiple PFMs and tasks.

This paper presents a rigorous empirical evaluation of Ultralytics YOLO26 against the YOLOv8 baseline, offering an independent real-world stress test of NMS-free architectures on non-COCO distributions. Engineered for edge deployment, YOLO26 introduces native end-to-end one-to-one label assignment, the removal of Distribution Focal Loss (DFL), and a spectral-constrained CSP-Muon backbone. We conducted a comprehensive, cross-scale comparative analysis across five model capacities, using the general object detection (Pascal VOC) and dense aerial small-object detection (VisDrone) datasets. Models are evaluated across accuracy (mAP_50 and mAP_50:95), model complexity, and hardware-specific CPU/GPU latency. Our findings revealed that while YOLO26 achieves a lower computational footprint and superior accuracy on Pascal VOC, with YOLO26-x reaching 0.635 mAP_50:95, this advantage narrows in dense aerial environments. On VisDrone, where over 75% of objects are under 2,000 pixels, both architectures struggle significantly, yielding a minimal performance gap (0.214 mAP_50:95 for YOLOv8-x vs. 0.224 mAP_50:95 for YOLO26-x). Crucially, hardware benchmarking demonstrates that YOLOv8 maintains a consistent edge in GPU inference latency across identical scales (e.g., 6.92 ms for YOLOv8-s vs. 8.38 ms for YOLO26-s), showing that NMS-free design does not inherently guarantee superiority in universal deployment. This work maps the operational boundaries of NMS-free frameworks to guide architecture selection based on dataset density, object scale, and hardware constraints.

The issues that must be considered regarding the utilization of synthetic data generated through LLMs for multilabel patent classification include (i) when the use of such data may help and (ii) why. Indeed, the former part appropriately adjusts for the possibility of improving results by an increase in sample size. The current experiment involves six open-source LLMs (from 3.8B to 12B parameters) for four real-data regimes in classification of 64 WIPO labels of assistive technologies. Both full-synthesis generation, conditioned on the label set, and paraphrasing methods are applied, with each used in combination with three classifier categories. It is shown that the claimed improvements in micro F1 for BERT-for-Patents from 0.120 to 0.702 mainly reflect a volume effect; indeed, replication with replacement in 165 examples produces 0.678. Thus, the improvement over the control is +0.024, while compared to the best baseline (focal loss reweighting) is +0.219. The second crucial point to consider here is that of evolving fidelity scores as the data generation regime varies. For low real-data regimes, the volume effect dominates and the correlation coefficient between maximum mean discrepancy (MMD) and classification performance equals r = +0.95. As more real data is used, the correlation becomes inverted and reaches r = -0.73 at the 1:10 regime (Fisher z = +6.47, p < 0.001, 95% CI on Delta r [ +0.96, +1.00 ]). In terms of a fixed budget allocation, combining real data (about 20-30%) with synthetic (70-80%) outperforms both purely synthetic and purely real strategies. Moreover, a corpus that allows for improvement in classification performance up to +0.58 in raw micro F1 may adversely affect a Jaccard-overlap retrieval proxy. Prompt-family variations for other genres may provide some explanation of the phenomenon, but using the standard-patent filter still decreases nDCG@10 by 26%.

Accurate classification of breast ultrasound images into benign, malignant, and normal categories is a critical clinical task complicated by speckle noise, acoustic shadowing, and inter-class visual ambiguity. Existing deep learning methods rely on single-stream architectures with generic augmentation that ignores ultrasound acquisition physics, and no prior method dedicates a stream to the lesion boundary features identified as the most diagnostically significant visual cue. We propose HADS-Net, a Hybrid Attention-Augmented Dual-Stream Network exploiting global texture and local boundary cues through two parallel pathways. Stream 1 applies physics-informed augmentation simulating speckle noise, acoustic shadowing, and gain variation before extracting features via pretrained EfficientNet-B3 projected to 512 dimensions. Stream 2 extracts Sobel edge maps processed by a lightweight CNN projected to the same 512-dimensional space. A cross-attention fusion module allows the texture stream to selectively query boundary features, producing a jointly optimised representation classified by an MLP trained with adaptive class-weighted focal loss. Five-fold stratified cross-validation with cosine annealing over 50 epochs is used, with the globally best checkpoint selected by lowest validation loss evaluated on a held-out test set. On the BUSI dataset, HADS-Net achieves 96.58% accuracy, macro ROC-AUC of 0.9978, macro F1 of 0.9654, and per-class F1-scores of 0.970, 0.951, and 0.976 for benign, malignant, and normal. No malignant lesion is misclassified as normal. These results confirm that modality-specific augmentation with cross-modal attention fusion is an effective strategy for ultrasound-based breast cancer diagnosis.

Deep neural networks achieve high accuracy on image classification tasks. Yet, they often produce overconfident predictions as which fail to express epistemic uncertainty, and frequently violate logical or structural constraints present in the data. These limitations are particularly pronounced in hierarchical classification, where predictions across fine and coarse levels must remain coherent. We propose, for the first time, a unified neurosymbolic and epistemic modelling framework that augments Swin Transformers with focal set reasoning and differentiable fuzzy logic. Rather than treating labels as isolated categories, our method induces data-driven focal sets within the learnt embedding space, which helps capture epistemic uncertainty over multiple plausible fine-grained classes. These focal sets form the basis of a belief-theoretic layer that uses fuzzy membership functions and t-norm conjunctions to encourage consistency between fine- and coarse-grained predictions. A learnable loss further balances calibration, mass regularisation, and logical consistency, allowing the model to adaptively trade off symbolic structure with data-driven evidence. In experiments on hierarchical image classification, our framework maintains accuracy on par with transformer baselines while providing more calibrated and interpretable predictions, reducing overconfidence and enforcing high logical consistency across hierarchical outputs. Our experimental results show that combining focal set reasoning with fuzzy logic provides a practical step toward deep learning models that are both accurate and epistemically aware.

Deep neural networks for medical image diagnosis often achieve high predictive accuracy while relying on spurious or clinically irrelevant visual cues, limiting their trustworthiness in practice. Post-hoc explanation methods are widely used to visualize model decisions in the form of saliency maps; however, these explanations do not influence how models learn during training, allowing non-causal or confounding features to persist. This motivates the incorporation of explanation supervision directly into the training objective to guide model attention toward clinically meaningful regions and promote clinically grounded decision-making. This paper presents a systematic approach to integrate explanation loss into model training and analyzes how different explanation loss designs and supervision strengths influence both predictive performance and spatial faithfulness of explanations. To quantitatively assess interpretability, two complementary explanation performance metrics-annotation coverage and saliency precision-are introduced, enabling rigorous evaluation beyond qualitative visualization. Our experimental results reveal a clear trade-off between explanation quality and explanation loss coefficients. Furthermore, quantitative statistical analysis yields consistently improved explanation alignment while maintaining comparable accuracy. Experiments were conducted on annotated chest X-ray datasets; however, the proposed framework is applicable to a broad range of annotated biomedical imaging modalities. Overall, these findings demonstrate that explanation supervision is not a monolithic design choice and provide practical guidance for incorporating explanation loss into training objectives under noisy clinical annotations.

With the widespread application of Unmanned Aerial Vehicles (UAVs) in bridge structural health monitoring, deep learning-based automatic crack detection has become a major research focus. However, practical UAV inspections still face four key challenges: weak crack features, degraded imaging conditions, severe class imbalance, and limited computational resources for practical UAV inspection workflows. To address these issues, this paper proposes a unified lightweight convolutional neural network framework composed of four synergistic components: a lightweight backbone network, a Convolutional Block Attention Module (CBAM) for channel and spatial enhancement, a directed robust augmentation strategy based on inspection-scene priors, and Focal Loss for hard-sample learning under class imbalance. Experiments on the SDNET2018 bridge deck dataset show that the proposed method achieves an inference speed of 825 FPS with only 11.21M parameters and 1.82G FLOPs. Compared with the baseline model, the complete framework improves the F1-score by 2.51% and recall by 3.95%. In addition, Grad-CAM visualizations indicate that the introduced attention module shifts the model's focus from scattered regions to precise tracking along crack trajectories. Overall, this study achieves a strong balance among accuracy, speed, and robustness, providing a practical solution for ground-station assisted real-time deployment in UAV bridge inspections. The source code is available at: https://github.com/skylynf/AttXNet .

Accurate multiclass segmentation of the Circle of Willis (CoW) is essential for neurovascular disease management but remains challenging due to complex vascular topology and variable morphology. Existing deep learning methods often suffer from vascular discontinuities and inter-class misclassification, while current topological loss functions incur prohibitive computational costs in 3D multiclass settings. To address these limitations, we propose an Anatomically-Guided Topology-Aware Loss (AG-TAL) and introduce a large-scale, multi-center CoW dataset with unified annotations to facilitate robust model training. AG-TAL specifically integrates a radius-aware Dice loss to address class imbalance in small vessels, a breakage-aware clDice loss that utilizes group convolutions to efficiently preserve local connectivity, and an adjacency-aware co-occurrence loss that leverages anatomical priors to enforce distinct boundaries between neighboring arteries. Evaluated using 5-fold cross-validation, AG-TAL achieved an average Dice score of 80.85% for all CoW arteries, with small arteries notably higher by 1.05-3.09% compared to state-of-the-art methods. Across six independent datasets, the performance of AG-TAL achieved Dice scores ranging from 74.46% to 81.17% for all CoW arteries, with improvements of 2.20% to 9.98% for small arteries compared to other methods. This study demonstrates the superiority of AG-TAL in identifying multiclass CoW arteries and its ability to generalize well to multiple independent datasets. Furthermore, reliability analyses and clinical applications in an Alzheimer's disease cohort validate the AG-TAL's robustness and its potential for discovering imaging-based morphological biomarkers.

Face Recognition (FR) is used in a variety of application domains, from entertainment and banking to security and surveillance. Such applications rely on the FR model to be robust and perform well in a variety of settings. To achieve this, state-of-the-art FR models typically use expressive adaptive margin loss functions, which tie the feature norm to concepts related to sample quality, such as recognizability and perceptual image quality. Recently, through the development of Face Image Quality Assessment (FIQA) techniques, biometric utility has become the preferred measure of face-image quality and has been shown to be a better predictor of the usefulness of samples for face recognition compared to more human-centric aspects, such as resolution, blur, and lighting, tied to general image quality. While image quality expressed through feature norms exhibits a certain level of correlation with biometric utility, it does not fully encapsulate all aspects of utility. To address this point, we propose a new adaptive margin loss, FunFace (Face Recognition Through Utility and Norm Estimation), which incorporates biometric utility, estimated by the Certainty Ratio, into the adaptive margin, taking inspiration from AdaFace. We show that FunFace (when used to train a face recognition model) achieves competitive results to other state-of-the-art FR models on benchmarks containing high-quality samples, while surpassing them on low quality benchmarks.

Instance-sensitive losses for semantic segmentation such as blob loss and CC loss were designed to address instance imbalance, ensuring small lesions generate the same gradient as large ones, but operate only on single-class segmentation. In multi-class settings, class imbalance poses an additional problem: rare classes with few instances receive a disproportionately small share of the training signal. We show that extending instance-sensitive losses to multi-class segmentation via a one-vs-rest class decomposition repurposes them to also address class imbalance, as uniform averaging over classes ensures each class contributes equally regardless of frequency. We further show that inverse-size weighting, which destabilizes training when applied globally due to weight imbalances across rare and common classes, becomes effective when integrated within the per-component loss, confining the reweighting to each component's spatial context. On the BraTS-METS 2025 dataset (260 test cases), multi-class CC loss improves foreground Dice (0.64 +/- 0.26 vs. 0.59 +/- 0.27 baseline) and rare-class Dice, while maintaining Panoptic Quality at DSC threshold 0.5. Multi-class blob loss achieves the best Panoptic Quality at threshold 0.5 (0.40 +/- 0.24 vs. 0.38 +/- 0.25 baseline) and recognition quality (0.53 +/- 0.29 vs. 0.49 +/- 0.30). Integrating inverse-size weighting within the per-component loss increases rare-class Dice to 0.44 +/- 0.36 at the cost of reduced detection quality.

Underwater acoustic target recognition is critical for maritime applications, yet it faces challenges arising from the complex and diverse nature of ship-radiated noise. To address these issues, we propose a robust deep learning-based framework. First, we introduce a feature extraction and fusion method based on variational mode decomposition (VMD) and the 3/2-D spectrum to generate high-fidelity 2-D DEMON spectral features, which effectively capture modulation envelope information. To further enhance feature representation, we design a one-dimensional convolutional neural network (1-D CNN) integrated with a novel Multi-Stage Multi-Type Attention Mechanism (MMATT) that adaptively refines features at different network depths. Within this mechanism, we propose a Residual Channel-Independent Spectral Attention Mechanism (R-CISAM) and a Multi-Scale Separate-and-Fuse Spectral Attention Mechanism (MS-SFSAM). Moreover, to mitigate performance degradation caused by severe class imbalance inherent in real-world ship-radiated noise data, we devise an Adjustable Class-Balanced Focal Loss (ACBFL), which provides flexibility across tasks with varying degrees of imbalance. Experimental results on a real-world ship-radiated noise dataset demonstrate that the proposed solutions effectively enhance underwater acoustic target recognition performance.

The LASSO-Clip-EN (LCEN) algorithm was previously introduced for nonlinear, interpretable feature selection and machine learning. However, its design and use was limited to regression tasks. In this work, we create a modified version of the LCEN algorithm that is suitable for classification tasks and maintains its desirable properties, such as interpretability. This modified LCEN algorithm is evaluated on four widely used binary and multiclass classification datasets. In these experiments, LCEN is compared against 10 other model types and consistently reaches high test-set macro F$_1$ score and Matthews correlation coefficient (MCC) metrics, higher than that of the majority of investigated models. LCEN models for classification remain sparse, eliminating an average of 56% of all input features in the experiments performed. Furthermore, LCEN-selected features are used to retrain all models using the same data, leading to statistically significant performance improvements in three of the experiments and insignificant differences in the fourth when compared to using all features or other feature selection methods. Simultaneously, the weighted focal differentiable MCC (diffMCC) loss function is evaluated on the same datasets. Models trained with the diffMCC loss function are always the best-performing methods in these experiments, and reach test-set macro F$_1$ scores that are, on average, 4.9% higher and MCCs that are 8.5% higher than those obtained by models trained with the weighted cross-entropy loss. These results highlight the performance of LCEN as a feature selection and machine learning algorithm also for classification tasks, and how the diffMCC loss function can train very accurate models, surpassing the weighted cross-entropy loss in the tasks investigated.

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. Although deep learning models have demonstrated significant accuracy, they frequently suffer from miscalibration, manifested as overconfidence in erroneous predictions. To facilitate clinical acceptance, it is imperative that models quantify uncertainty in a manner that correlates with prediction correctness, allowing clinicians to identify unreliable outputs for further review. To address this necessity, this paper proposes a probabilistic optimization framework grounded in Bayesian deep learning. Specifically, the Confidence-Uncertainty Boundary Curve (CUBC) is first explored as an intermediate operational target. Grounded in this target, a novel Confidence-Uncertainty Boundary Loss (CUB-Loss) is proposed to regularize the alignment between prediction confidence and uncertainty estimates during training, imposing penalties on high-certainty errors and low-certainty correct predictions. Upon completion of training optimization, a Boundary Curve Calibration Error (BCCE) metric is further introduced to measure the degree of boundary alignment in the calibrated model. Building on this measurement, a Dual Temperature Scaling (DTS) strategy is devised to perform post-hoc refinement, further adjusting the posterior predictive distribution across different confidence-uncertainty regions. The proposed framework is validated on three distinct medical imaging tasks: automatic screening of pneumonia, diabetic retinopathy detection, and identification of skin lesions. Empirical results demonstrate that the proposed approach improves uncertainty calibration across diverse modalities, maintains robust performance in data-scarce scenarios, and remains effective on severely imbalanced datasets, underscoring its potential for real clinical deployment.