Photoplethysmography

Photoplethysmography (PPG) is widely used in wearable health monitoring, but its reliability is often degraded by noise and motion artifacts, limiting downstream applications such as heart rate (HR) estimation. This paper presents a deep learning framework for PPG denoising with an emphasis on preserving physiological information. In this framework, we propose DPNet, a Mamba-based denoising backbone designed for effective temporal modeling. To further enhance denoising performance, the framework also incorporates a scale-invariant signal-to-distortion ratio (SI-SDR) loss to promote waveform fidelity and an auxiliary HR predictor (HRP) that provides physiological consistency through HR-based supervision. Experiments on the BIDMC dataset show that our method achieves strong robustness against both synthetic noise and real-world motion artifacts, outperforming conventional filtering and existing neural models. Our method can effectively restore PPG signals while maintaining HR accuracy, highlighting the complementary roles of SI-SDR loss and HR-guided supervision. These results demonstrate the potential of our approach for practical deployment in wearable healthcare systems.

Electrocardiography (ECG) is the clinical gold standard for cardiovascular disease (CVD) assessment, yet continuous monitoring is constrained by the need for dedicated hardware and trained personnel. Photoplethysmography (PPG) is ubiquitous in wearable devices and readily scalable, but it lacks electrophysiological specificity, limiting diagnostic reliability. While generative methods aim to translate PPG into clinically useful ECG signals, existing approaches are limited by the misalignment of physiological semantics in generative models and the complexity of modeling in high-dimensional signals. To address these limitations, we propose PPGFlowECG, a two-stage framework that aligns PPG and ECG in a shared latent space using the CardioAlign Encoder and then synthesizes ECGs with latent rectified flow. We further provide a formal analysis of this coupling, showing that the CardioAlign Encoder is necessary to guarantee stable and semantically consistent ECG synthesis under our formulation. Extensive experiments on four datasets demonstrate improved synthesis fidelity and downstream diagnostic utility. These results indicate that PPGFlowECG supports scalable, wearable-first CVD screening when standard ECG acquisition is unavailable.

Reflective photoplethysmography (PPG) has become the default sensing technique in wearable devices to monitor cardiac activity via a person's heart rate (HR). However, PPG-based HR estimates can be substantially impacted by factors such as the wearer's activities, sensor placement and resulting motion artifacts, as well as environmental characteristics such as temperature and ambient light. These and other factors can significantly impact and decrease HR prediction reliability. In this paper, we show that state-of-the-art HR estimation methods struggle when processing representative data from everyday activities in outdoor environments, likely because they rely on existing datasets that captured controlled conditions. We introduce a novel multimodal dataset and benchmark results for continuous PPG recordings during outdoor activities from 16 participants over 13.5 hours, captured from four wearable sensors, each worn at a different location on the body, totaling 216,hours. Our recordings include accelerometer, temperature, and altitude data, as well as a synchronized Lead I-based electrocardiogram for ground-truth HR references. Participants completed a round trip from Zurich to Jungfraujoch, a tall mountain in Switzerland over the course of one day. The trip included outdoor and indoor activities such as walking, hiking, stair climbing, eating, drinking, and resting at various temperatures and altitudes (up to 3,571,m above sea level) as well as using cars, trains, cable cars, and lifts for transport -- all of which impacted participants' physiological dynamics. We also present a novel method that estimates HR values more robustly in such real-world scenarios than existing baselines.