Deep learning-based multi-level airway collapse site localization on obstructive sleep apnea patients based on snoring sounds

Sleep-disordered breathing, including snoring, hypopnea, and obstructive apnea, is the hallmark of obstructive sleep apnea, whose severity is quantified by the Apnea-Hypopnea Index (AHI). As conventional polysomnography is costly and clin- ically demanding, microphone-only detection has emerged as a noninvasive alternative for screening. We propose ALE- Confidence Fusion Sound Event Detection (ACF-SED), the first framework that directly injects the per-frame confidence map of an Adaptive Line Enhancer (ALE) into Transformer atten- tion biasing and feature modulation, rather than as mere pre- processing. A Multi-Resolution ALE Bank aggregates three parallel NLMS filters at distinct decorrelation delays, while a Confidence-Guided Cross-Path block couples event and noise streams via gated cross-attention. On the Audio-Polygraphy Dataset for Sleep Apnea Analysis, ACF-SED achieves state- of-the-art detection across Event-F1, Segment-F1, and PSDS, enabling end-to-end AHI estimation.

Obstructive sleep apnea (OSA) is a sleep disorder that affects nearly one billion people globally and significantly elevates cardiovascular risk. Traditional diagnosis through polysomnography is resource-intensive and limits widespread access, creating a critical need for accurate and efficient alternatives. In this paper, we introduce KindSleep, a deep learning framework that integrates clinical knowledge with single-channel patient-specific oximetry signals and clinical data for precise OSA diagnosis. KindSleep first learns to identify clinically interpretable concepts, such as desaturation indices and respiratory disturbance events, directly from raw oximetry signals. It then fuses these AI-derived concepts with multimodal clinical data to estimate the Apnea-Hypopnea Index (AHI). We evaluate KindSleep on three large, independent datasets from the National Sleep Research Resource (SHHS, CFS, MrOS; total n = 9,815). KindSleep demonstrates excellent performance in estimating AHI scores (R2 = 0.917, ICC = 0.957) and consistently outperforms existing approaches in classifying OSA severity, achieving weighted F1-scores from 0.827 to 0.941 across diverse populations. By grounding its predictions in a layer of clinically meaningful concepts, KindSleep provides a more transparent and trustworthy diagnostic tool for sleep medicine practices.

Sleep is essential for health, yet studying its dynamics requires manual sleep staging, a labor-intensive step in research and clinical care. Across centers, polysomnography (PSG) recordings are traditionally scored in 30-s epochs for pragmatic, not physiological, reasons and vary in electrode count, montage, and subject characteristics. These constraints challenge harmonized multi-center studies and the discovery of robust biomarkers on shorter timescales. We present AnySleep, a deep neural network that scores sleep from any electroencephalography (EEG) or electrooculography (EOG) data at adjustable temporal resolutions. We trained and validated the model on over 20,000 overnight recordings (> 200,000 hours of EEG and EOG) from 28 datasets across multiple clinics to promote robust generalization across sites. The model attains state-of-the-art performance and surpasses or equals established baselines at 30-s epochs. Performance improves with more channels, yet remains strong when EOG is absent or only EOG or single EEG derivations (frontal, central, or occipital) are available. On sub-30-s timescales, the model captures short wake intrusions consistent with arousals and improves prediction of pathophysiological conditions (obstructive sleep apnea, narcolepsy type 1, insomnia) over 30-s scoring. We make the model publicly available to facilitate large-scale studies with heterogeneous electrode setups and accelerate biomarker discovery in sleep.