A Privacy-Preserving Federated Learning Method for Heterogeneous Clients

Protecting sensitive health data while enabling collaborative analysis is a central challenge in healthcare. Traditional machine learning (ML) requires institutions to pool anonymized patient records, centralizing analytical development and privacy risks at a single site. Privacy-enhancing technologies (PETs), including Differential Privacy (DP) and Homomorphic Encryption (HE), can mitigate these risks. However, they are mainly studied in conventional data-sharing settings and often introduce trade-offs, including reduced model utility, higher computational cost, and increased implementation complexity. Federated Learning (FL) reduces data centralization by enabling institutions to train models locally and share only model updates. Nevertheless, FL does not eliminate privacy risks, as shared parameters or gradients may still reveal sensitive information. Integrating DP or HE into FL can strengthen privacy guarantees, yet their comparative performance and deployment implications in real-world healthcare settings remain unclear. We systematically evaluated DP and HE integration in FL under real-world conditions, comparing them with standard FL and centralized ML (cML) to quantify privacy-utility trade-offs in multi-institutional settings. Using nationwide Swedish healthcare data, we evaluated cardiovascular disease risk prediction using logistic regression (LR) and neural network (NN) learners. FL with HE achieved performance comparable to cML but introduced measurable cryptographic overhead, particularly in the NN implementation. FL with DP incurred lower computational cost; however, LR was more sensitive to calibrated noise than the NN, resulting in greater performance degradation. Our findings provide practical guidance for deploying privacy-preserving FL in fragmented healthcare systems.

Differentially private federated learning (DP-FL) enables clients to collaboratively train machine learning models while preserving the privacy of their local data. However, most existing DP-FL approaches assume that all clients share a uniform privacy budget, an assumption that does not hold in real-world scenarios where privacy requirements vary widely. This privacy heterogeneity poses a significant challenge: conventional client selection strategies, which typically rely on data quantity, cannot distinguish between clients providing high-quality updates and those introducing substantial noise due to strict privacy constraints. To address this gap, we present the first systematic study of privacy-aware client selection in DP-FL. We establish a theoretical foundation by deriving a convergence analysis that quantifies the impact of privacy heterogeneity on training error. Building on this analysis, we propose a privacy-aware client selection strategy, formulated as a convex optimization problem, that adaptively adjusts selection probabilities to minimize training error. Extensive experiments on benchmark datasets demonstrate that our approach achieves up to a 10% improvement in test accuracy on CIFAR-10 compared to existing baselines under heterogeneous privacy budgets. These results highlight the importance of incorporating privacy heterogeneity into client selection for practical and effective federated learning.

Federated learning (FL) enables collaborative training of machine learning models without sharing sensitive client data, making it a cornerstone for privacy-critical applications. However, FL faces the dual challenge of ensuring learning quality and robust privacy protection while keeping resource consumption low, particularly when using computationally expensive techniques such as homomorphic encryption (HE). In this work, we enhance an FL process that preserves privacy using HE by integrating it with synthetic data generation and an interleaving strategy. Specifically, our solution, named Alternating Federated Learning (Alt-FL), consists of alternating between local training with authentic data (authentic rounds) and local training with synthetic data (synthetic rounds) and transferring the encrypted and plaintext model parameters on authentic and synthetic rounds (resp.). Our approach improves learning quality (e.g., model accuracy) through datasets enhanced with synthetic data, preserves client data privacy via HE, and keeps manageable encryption and decryption costs through our interleaving strategy. We evaluate our solution against data leakage attacks, such as the DLG attack, demonstrating robust privacy protection. Also, Alt-FL provides 13.4% higher model accuracy and decreases HE-related costs by up to 48% with respect to Selective HE.