HERO: Hierarchical Evidential Reasoning Optimization for Radiology Report Generation via Reason-then-Summarize

Medical report generation has made significant progress with the rise of modern vision-language models and the growing availability of large-scale medical datasets. However, hallucinations remain a major challenge, largely due to the limitations of supervised fine-tuning (SFT), which prioritizes lexical similarity to reference reports rather than clinical correctness. While reinforcement learning has shown strong performance in domains with verifiable rewards such as mathematics and code generation, its application to open-ended medical tasks remains limited. Existing work focuses on evaluating final answers, overlooking the model's reasoning, despite evidence that flawed reasoning can degrade overall performance. In this study, we propose a framework that verifies the model's reasoning process by integrating anatomical regions, bounding boxes, and region-level textual descriptions. We design spatial and factual reward mechanisms to ensure that the model's reasoning is both visually grounded and factually accurate. Starting from Qwen3-VL-8B-Instruct as our base model, we adapt it to the medical domain using supervised fine-tuning, introduce reasoning capability through a cold-start SFT stage, and refine it with reinforcement learning. We find that RL provides performance gains beyond those achievable through SFT alone, and that jointly verifying both reasoning steps and final outputs yields larger improvements than verifying either in isolation. We further identify multiple modes of reward hacking in the RL stage. Finally, the model's structured think traces enhance interpretability, making its outputs easier to audit for clinical use.

We propose MARL-Rad, a multi-modal multi-agent reinforcement learning framework for radiology report generation that trains the entire agentic system on policy within its deployed radiology workflow. MARL-Rad addresses the limitation of post-hoc agentization, where fixed LLMs are organized into hand-designed agentic workflows without being optimized for their assigned roles. Our framework decomposes chest X-ray interpretation into region-specific agents and a global integrating agent, and jointly optimizes them using clinically verifiable rewards. Experiments on the MIMIC-CXR and IU X-ray datasets show that MARL-Rad consistently improves clinical efficacy metrics such as RadGraph, CheXbert, and GREEN scores, achieving state-of-the-art clinical efficacy performance. Further analyses show that MARL-Rad improves laterality consistency and produces more accurate and detailed reports. A blinded clinician evaluation further suggests that MARL-Rad produces reports clinically comparable to ground-truth reports.

Radiology report generation (RRG) has recently benefited from large language models, which substantially improve report fluency. However, clinically faithful generation remains challenging because current supervision is still imposed mostly at the report level. This creates a granularity mismatch: radiology reports are composed of disease-grounded findings, while existing methods are trained mainly with whole-report objectives. To address this problem, we propose Graph-Supervised Hierarchical Clinical Alignment, which reformulates image-report supervision as a hierarchical clinical alignment problem. Our method structures this alignment as a disease-conditioned process, where supervision is decomposed into two levels: Disease-Centric Alignment for fine-grained disease-specific correspondence, and Global Clinical Semantic Alignment for report-level semantic coherence. A clinical knowledge graph is used as a training-time-only structural prior that defines disease-specific supervision units and their clinical relationships, introducing no additional overhead at inference. Because standard contrastive alignment could produce false negatives when studies share overlapping pathologies, we combine instance-conditioned discriminative matching with disease-conditioned soft regularization, enabling fine-grained yet clinically consistent cross-modal representations. Experiments on MIMIC-CXR, IU-Xray, and COV-CTR show that our method consistently improves performance on both conventional and clinical metrics. Notably, our 3B model surpasses several prior systems with larger 7B/13B backbones, suggesting that improving supervision structure, rather than increasing model size, can be more effective for RRG.