Feature-based morphological analysis of shape graph data

A central objective of machine learning is to identify structure and patterns in data. Advances in data acquisition have increasingly produced datasets whose observations possess rich geometric form, giving rise to shape spaces that encode variability in object geometry. Such datasets arise across a wide range of disciplines, including biology, medicine, anthropology, and computer vision, where subtle geometric differences often carry important scientific information. Traditional machine learning methods, however, are frequently ill-equipped to account for the nonlinear geometric structure underlying these data. This survey synthesizes a rapidly growing body of work on shape space analysis, which provides a mathematical and computational framework for the study of geometric data. Drawing on ideas from differential geometry, statistics, and machine learning, we organize the literature around a common analytical pipeline: shape representation and parameterization, the rigorous construction of robust geodesic metrics, statistical analysis on shape spaces, and geometry-aware learning methods. We discuss how these tools enable the characterization of shape variability, the comparison of geometric objects, and the analysis of structural trajectories across populations and time. To illustrate the breadth of the field, we highlight applications spanning multiple scales of biological organization, including studies of subcellular morphology and primate tooth evolution. Across these and many other domains, researchers face common challenges arising from complex, nonlinear, and often unaligned geometric variation. The review concludes by identifying key theoretical and computational challenges, as well as emerging opportunities driven by increasingly large and diverse geometric datasets.

Neuronal morphology encodes critical information about circuit function, development, and disease, yet current methods analyze topology or graph structure in isolation. We introduce GraPHFormer, a multimodal architecture that unifies these complementary views through CLIP-style contrastive learning. Our vision branch processes a novel three-channel persistence image encoding unweighted, persistence-weighted, and radius-weighted topological densities via DINOv2-ViT-S. In parallel, a TreeLSTM encoder captures geometric and radial attributes from skeleton graphs. Both project to a shared embedding space trained with symmetric InfoNCE loss, augmented by persistence-space transformations that preserve topological semantics. Evaluated on six benchmarks (BIL-6, ACT-4, JML-4, N7, M1-Cell, M1-REG) spanning self-supervised and supervised settings, GraPHFormer achieves state-of-the-art performance on five benchmarks, significantly outperforming topology-only, graph-only, and morphometrics baselines. We demonstrate practical utility by discriminating glial morphologies across cortical regions and species, and detecting signatures of developmental and degenerative processes. Code: https://github.com/Uzshah/GraPHFormer

The quantitative analysis of 3D neuronal morphologies requires capturing both graph topology and spatial geometry. Current message-passing Graph Neural Networks (GNNs) are bounded by the 1-Weisfeiler-Lehman (1-WL) test, limiting their ability to capture cycles induced by spatial proximities. To address this, we propose a training-free geometric prior based on tropical algebraic geometry. We apply the recently established tropical Abel-Jacobi transform and polarization distances to machine learning on tree-structured data. We introduce a structural transformation pipeline, comprising cycle space augmentation and quotient space construction, to convert spatial trees into cyclic metric graphs suitable for embedding into the Tropical Jacobian. Computing exact tropical polarization distances requires solving the NP-Hard Closest Vector Problem (CVP) on integer lattices. Instead of relying on explicit approximations with quantization errors (e.g., Babai's rounding), we adopt a continuous relaxation on the universal cover of the Albanese torus. We show that the discrete Arakelov-Green measure, computed in closed form via the graph Laplacian's generalized inverse, decomposes exactly into the intrinsic path metric minus the unquantized polarization distance on this cover, avoiding integer lattice searches. This metric yields two descriptors: eigenvectors provide node-level structural coordinates, and the permutation-invariant eigenvalue spectrum provides a graph-level signature. On the BREC benchmark, the eigenvector formulation demonstrates expressivity beyond the 1-WL limit. On 3D morphology datasets (ACT-4, JML-4, BIL-6), the spectrum seamlessly integrates into standard architectures (VAEs, GNNs, Tree-LSTMs) without additional trainable parameters, outperforming explicit lattice approximations and improving classification accuracy over existing spatial models.