Whole-Brain Connectomic Graph Model Enables Whole-Body Locomotion Control in Fruit Fly

Robotic bodies are inherently distributed in sensing and actuation, yet learning-based control still commonly relies on centralized information processing. This work studies the problem of information organization in communication-constrained embodied control: which computations should remain local, and which information is worth transmitting for whole-body coordination. We propose FlyCNS, an embodied information-organization framework inspired by the Drosophila brain--nerve-cord connectome. FlyCNS preserves local sensorimotor computation within each limb and enables selective long-range communication through separate ascending and descending routing pathways. From a real connectome, FlyCNS extracts the directional structural complexity of these two pathway types and uses it as a weak prior over communication allocation, while message content, transmission timing, and locomotion policies remain task-adaptive and are learned through reinforcement learning. In Unitree Go1 simulation, FlyCNS exhibits more graceful performance degradation as the communication budget is tightened. Under the most restrictive setting, it uses only about 21--22% of the communication of the full-communication reference, while still maintaining a tracking score of approximately 0.882 under both command protocols, with a gap of no more than 6.1% from the full-communication reference. These results indicate that real neural connectomes can inform not only the structural design of control networks, but also provide transferable inductive biases for information organization across embodiments, guiding robots in balancing local computation and long-range coordination under limited communication resources.

Connectomes now map the neurons and synapses of an adult fly's brain and nerve cord, but how much of behaviour follows from the wiring is unknown. Here we turn one such connectome into a spiking network of 172,433 neurons with a published brain model's untuned parameters, and run it alone and inside a simulated body. Two fixed rules join them: odours and looming objects drive sensory neurons, and motor neurons move the legs. Alone, the network passes a signal to the motor neurons it is known to drive when the pathway supplies about 2% or more of their input. In the body, the fly navigates around obstacles to 95% of the odour sources. A rewiring that keeps each neuron's connection counts and signs reaches 18%, and the fly's leg commands replayed with the senses off reach almost none, so navigation needs the measured wiring and sensory feedback. Dopamine-gated weakening of the mushroom body's output synapses turns approach to an odour into avoidance, which requires the pairing and is odour-specific once one olfactory synapse class is scaled. An untrained connectome thus supports a behaviour and its learned reversal, and the pathways it cannot drive mark what the diagram leaves out.

While deep learning models achieve state-of-the-art performance in complex tasks, they remain brittle when faced with new environments or sensory deprivation. In contrast, biological systems exhibit remarkable tolerance to these challenges. We address this vulnerability by developing a recurrent neural network (RNN) whose architecture is directly derived from the synaptic-resolution brain connectome of the fruit fly Drosophila melanogaster. We demonstrate the feasibility of training the fly connectome neural network (FLYNN) to perform vision-based navigation in MuJoCo, achieving performance comparable to modern hand-crafted networks of similar parameter counts. Crucially, FLYNN exhibits superior resistance to out-of-distribution (OOD) data and tolerance to sensory loss without further training. It remained functional even under total vision loss while hand-crafted networks largely failed, even when specifically trained with camera dropout. Principal Component Analysis (PCA) of the internal state of FLYNN suggests that it exhibits a particularly high degree of representational modularity, which might be related to its robustness. Our work provides a new direction for designing resilient artificial agents following the topology of biological brains.