Automatic evaluation of medical open-ended question answering (OEQA) remains challenging due to the need for expert annotations. We evaluate whether large language models (LLMs) can act as judges of semantic equivalence in French medical OEQA, comparing closed-access, general-purpose, and biomedical domain-adapted models. Our results show that LLM-based judgments are strongly influenced by the model that generated the answer, with agreement varying substantially across generators. Domain-adapted and large general-purpose models achieve the highest alignment with expert annotations. We further show that lightweight adaptation of a compact model using supervised fine-tuning (SFT) and Group Relative Policy Optimization (GRPO) substantially improves performance and reduces generator sensitivity, even with limited data. Overall, our findings highlight the need for generator-aware evaluation and suggest that carefully adapted small models can support scalable evaluation in low-resource medical settings.
Figures & tables
Figure 1: Overview of the evaluation and alignment pipeline. French medical OEQA questions are answered by multiple LLM generators and annotated by a clinician for binary semantic equivalence. LLM evaluators judge the same instances using an identical prompt. A lightweight evaluator (Phi-3.5-mini) is further aligned via SFT and GRPO, and improvements are validated through paired significance testing.
Judge
P
R
F1
Accuracy
Pearson r
MedGemma-27B
52.17
72.00
60.50
71.80
40.67
Qwen-80B
64.62
56.00
60.00
77.60
44.77
Gemini-2.5-Pro
65.35
44.00
52.59
76.20
38.81
GPT-5.1
76.19
32.00
45.07
76.60
38.27
Phi-3.5-mini
35.94
98.00*
52.59
47.00
27.49
SFT-Phi-3.5-mini
38.81
91.33
54.47
54.20
29.79
Table 1: Agreement between LLM judges and the medical expert on binary equivalence judgments. Best scores are shown in bold. The symbol * indicates the best-performing variant among the base, SFT-aligned, and GRPO-aligned models.
Metric
Pearson r
ROUGE-L
25.40
BLEU
17.16
BERTScore-F1
14.88
Table 2: Pearson correlation between automatic similarity metrics and expert equivalence judgments.
Figure 2: Heatmap of F1 scores for each judge model across answer-generating models.
Figure 3: Comparison of F1 scores of Phi models on the text generated by multiple LLMs
Comparison (A vs. B)
Acc (A)
Acc (B)
Δ Acc (Acc (B) - (Acc (A))
McNemar p
Base vs. SFT
47.00
54.20
7.20
1.25E-06
Base vs. GRPO
47.00
71.40
24.40
1.44E-16
SFT vs. GRPO
54.20
71.40
17.20
2.64E-11
Table 3: McNemar test results for accuracy differences between the base, SFT-only, and GRPO-aligned evaluators on the test set.
Appendix figures & tables7 assets
Supplementary material from the paper’s appendix.
Appendix
Hyperparameter
SFT
GRPO
Training set size
166
184
Validation set size
18
–
Number of epochs
5
2
Learning rate
5×10−6
1×10−5
Batch size
1
1
Gradient accumulation steps
4
4
Appendix
Table 4: Hyperparameters used for SFT and GRPO alignment of the Phi-3.5 evaluator.
Comparison (A vs. B)
Pearson r(A)
Pearson r(B)
Δ Prearson r (r(B) - r(A))
Bootstrap p
Permutation p
Base vs. SFT
27.49
29.79
2.3
0.5533
0.4255
Base vs. GRPO
27.49
36.33
8.84
0.4985
0.1106
SFT vs. GRPO
29.79
36.33
6.54
0.5138
0.1899
Appendix
Table 5: Paired bootstrap and permutation test results for correlation differences between the base, SFT-only, and GRPO-aligned evaluators on the test set.
Comparison (A vs. B)
F1 (A)
F1 (B)
Δ F1 (F1 (B) - F1 (A))
Bootstrap p
Permutation p
Base vs. SFT
52.59
54.47
1.88
0.5049
0.092
Base vs. GRPO
52.59
57.06
4.47
0.5002
0.1278
SFT vs. GRPO
54.47
57.06
2.59
0.5338
0.3389
Appendix
Table 6: Paired bootstrap and permutation test results for F1-score differences between the base, SFT-only, and GRPO-aligned evaluators on the test set.
Model Variant
TP
FP
TN
FN
F1
PHI-3.5 (Base)
147
262
88
3
0.526
PHI-3.5 + GRPO (after SFT-60 steps)
142
246
104
8
0.528
PHI-3.5 + GRPO (after SFT to convergence)
95
88
262
55
0.571
PHI-3.5 + GRPO (from scratch)
139
219
131
11
0.547
Appendix
Table 7: Ablation of alignment schedules for Phi-3.5-mini. We compare the base model, GRPO applied from scratch, GRPO after a short SFT warm-up, and GRPO applied after SFT convergence. The strongest performance is obtained when GRPO is applied after SFT loss stabilization.
Question
Citez par quels moyens réaliser une laryngoscopie indirecte ?
Clinical Context
Un homme de 60 ans consulte pour une dysphagie aux solides s’aggravant depuis 2 mois. Il a perdu 6 kg en 6 mois. L’examen ORL par laryngoscopie indirecte retrouve une lésion d’allure tumorale du sinus piriforme droit.
Ground Truth (Expert Reference)
– Au miroir (miroir laryngé avec lumière frontale, de Clar)
– Au nasofibroscope
Appendix
Table 8: Illustrative example of semantic equivalence judgments in French medical OEQA. Answers with widely different formulations, levels of detail, and terminology can still be judged equivalent by the clinician as long as the essential medical content is preserved, while concise but incorrect answers are rejected.
Judge
Generator
Accuracy
P
R
F1
Spearman ρ
GEMINI-2.5-PRO
Gemma-3-4B-IT
75.00
69.23
51.43
59.02
42.54
GEMINI-2.5-PRO
SFT-LLaMA-13B-Chat
78.00
100.00
24.14
38.89
42.93
GEMINI-2.5-PRO
MedGemma-4B-IT
70.00
58.33
41.18
48.28
28.87
GEMINI-2.5-PRO
Qwen-4B-IT
70.00
60.61
54.05
57.14
34.31
GEMINI-2.5-PRO
SFT-Qwen-4B
88.00
63.64
46.67
53.85
47.89
GPT-5.1
Gemma-3-4B-IT
75.00
100.00
28.57
44.44
45.43
Appendix
Table 9: Detailed agreement metrics between LLM judges and the expert annotations, broken down by answer-generating model.
Generating Model
Mean # Characters
Gemma-3-4B-IT
1852.88
SFT-LLaMA-13B-Chat
121.26
MedGemma-4B-IT
1909.31
Qwen-4B-IT
1620.27
SFT-Qwen-4B
296.27
Appendix
Table 10: Average number of characters per answer for each generating model.
Large language model (LLM)-as-a-judge research uses language models to score, compare, and verify AI outputs as scalable alternatives to human evaluation.
Background: Expert-annotated benchmarks for non-English open-response clinical questions are scarce. LLM-as-a-judge systems may scale evaluation but require validation. Objective: To introduce MedQADE, a standardized German open-response clinical benchmark with physician reference annotations, and evaluate LLM-as-a-judge alignment, self- and intra-family bias, and abstention. Methods: The benchmark contains 3,800 question-answer sets with answers from five student LLMs and annotations from 10 physicians. All 10 rated the 200-question core; two primary raters assessed each of 3,600 extension questions, with the tenth resolving disagreements. Nine LLM evaluators assessed all sets. We assessed physician reliability, student-model accuracy, evaluator alignment, bias, and abstention. Results: Physicians showed moderate-to-substantial agreement on answer correctness (unweighted mean pairwise Cohen's kappa = 0.612) but limited agreement on question difficulty (Krippendorff's alpha = 0.208 using squared numeric-score distances). Student-model accuracy was 17.8%-66.0% and generally decreased with physician-rated difficulty. Gemini 3 Flash approached the leave-one-out physician reference (kappa = 0.694 vs 0.709). Four of five models rated their own responses more favorably than out-of-family evaluators; five of six intra-family comparisons were positive. Physician abstention increased with perceived difficulty. Seven of nine LLM evaluators abstained in no more than 0.51% of evaluations; the two strongest evaluators assigned definitive labels to every response. Conclusions: Strong LLM evaluators approached physician agreement, but evaluator bias and low observed abstention warrant physician validation and further assessment of selective deferral before fully automated evaluation. These results do not establish clinical safety.
William Philipp, Finn Fassbender, Daniel Fister +12
Section for Clinical Research-IT, Institute of Medical Biometry and Statistics, University of Luebeck, Luebeck, Germany · Medical Faculty, University of Tübingen, Tübingen, Germany · German Medical Students’ Association (bvmd), Berlin, Germany +9
The development of large language models (LLMs) has led to an increased focus on their adaptation to specialized domains and languages, yet the effectiveness of domain adaptation strategies remains unclear. We present a study of medical domain adaptation using French medical question-answering (QA) as a case study. We compare continual pretraining (CPT), supervised fine-tuning (SFT), and their combination across three model families, multiple sizes, and three initialization types, explicitly disentangling adaptation effects from base model choice. We evaluate both multiple-choice (MCQA) and open-ended QA (OEQA) under greedy and constrained decoding using automatic metrics and LLM-as-a-Judge evaluation. For MCQA, CPT+SFT most often achieves the best scores, but gains over SFT are small and frequently not statistically significant, making SFT a strong and cost-effective default. For OEQA, CPT consistently improves overlap-based metrics, while SFT often degrades generation quality; instruction tuning and CPT+SFT are preferred by LLM-based evaluation. Cross-lingual experiments further show effective transfer from French adaptation to English benchmarks. Overall, we provide practical guidelines for selecting adaptation strategies under computational constraints.
Ikram Belmadani, Oumaima El Khettari, Carlos Ramisch +3
Aix-Marseille Univ., CNRS, LIS UMR 7020, 13000 Marseille, France · Nantes Univ., École Centrale Nantes, CNRS, LS2N UMR 6004, 44000 Nantes, France · Grenoble Alpes Univ., CNRS, INRIA, Grenoble INP, LIG UMR 5217, 38000 Grenoble, France
Automated judges of clinical artificial intelligence (AI) outputs are necessary, but large language model (LLM) judges are costly and slow at scale. We compared Jev, a decision language model that returns structured judgments, with frontier and open-weight LLM judges in four use cases. On 118 pediatric answers, Jev's agreement with physicians' ordinal quality ratings (Gwet's AC2 0.50; expected score 0.53) matched or exceeded that of seven of 12 LLM judges, including frontier models, Claude Opus 5.5 (0.49) and GPT-6 (0.38). On physician-graded binary HealthBench criteria, Jev matched or exceeded four of six LLM judges. On MedHELM's open-ended tasks, Jev's agreement with a three-LLM jury approached or exceeded the jurors' internal agreement. On HealthBench Professional, Jev matched the benchmark's reference judge, GPT-5.4, on 91% of criteria (other judges, 91-93%). Frontier judges cost 73-294 times more than Jev and took 7-57 times longer. Jev may enable efficient clinical AI evaluation at scale.
Rotem Gershon, Seffi Cohen, Dean Ariel +11
Innovation Division, Clalit Research Institute, Clalit Health Services, Ramat-Gan, Israel. · Stein Faculty of Computer and Information Science, Ben Gurion University of the Negev, Be’er Sheva, Israel. · Department of Family Medicine, Clalit Health Services, Tel Aviv, Israel. +4