Duala: Dual-Level Alignment of Subjects and Stimuli for Cross-Subject fMRI Decoding

Cross-subject brain-to-visual decoding remains a core challenge in brain-computer interfaces due to severe inter-individual variability that induces systematic subject-specific functional misalignment. To address this issue, we propose MindAdapter, a parameter-efficient few-shot calibration framework for pretrained brain-to-visual decoding models. MindAdapter adopts a decoupled linear-residual cascade alignment paradigm by freezing a pretrained explicit brain functional alignment backbone (coarse) and introducing a lightweight nonlinear residual adapter (fine), thereby disentangling global cross-subject correspondence from subject-specific residual corrections for fine-grained spatial and semantic calibration. To further preserve global representational stability, we design a topology-anchored dual-stream manifold constraint, where a small set of shared stimuli serves as topological pins with voxel-level paired supervision, while a semantic stream enforces consistency through a frozen vision-language decoder on unpaired brain data. Together, MindAdapter efficiently injects subject-specific corrections while maintaining the global representational geometry learned during pretraining. Experiments on the Natural Scenes Dataset (NSD) demonstrate that MindAdapter substantially improves cross-subject visual reconstruction and retrieval accuracy using only a few shared stimuli, offering a practical and data-efficient solution for personalized brain-to-visual decoding.

Existing cross-subject fMRI decoding methods typically train a model on multiple scanned subjects and then adapt it to a new subject using substantial paired fMRI-image data. However, in realistic scenarios, new-subject fMRI data are often limited due to costly data acquisition, and raw data from previous subjects may be inaccessible, leading existing methods to suffer performance degradation during new-subject adaptation. In this paper, we identify that this degradation stems from two key issues: brain-side instability caused by large subject differences in fMRI responses, and image-side supervision unreliability caused by fine-grained visual details that are not reliably supported by limited fMRI signals. To address these challenges, we propose StableMind, a regularized adaptation framework designed to improve brain-side representation stability and image-side supervision reliability. (1) To stabilize brain representations, StableMind reuses ridge projections from the pretrained model as adaptation priors to constrain limited-data new-subject adaptation, and applies Fourier-based feature-level brain augmentation to improve robustness to individual variability. (2) To improve image supervision reliability, StableMind introduces difficulty-aware image blur for brain-image alignment, reducing the influence of fine-grained visual details that are weakly supported by limited fMRI signals while preserving stable visual structure. Experiments on the Natural Scenes Dataset under a unified 1-hour adaptation protocol demonstrate that StableMind achieves 84.02% image retrieval accuracy and 81.66% brain retrieval accuracy averaged over four subjects, surpassing the state-of-the-art method by 5.71% brain retrieval accuracy with fewer trainable adaptation parameters. Our code is available at https://github.com/lingeringlight/StableMind.

Visual decoding from brain signals is a key challenge at the intersection of computer vision and neuroscience, requiring methods that bridge neural representations and computational models of vision. A field-wide goal is to achieve generalizable, cross-subject models. A major obstacle towards this goal is the substantial variability in neural representations across individuals, which has so far required training bespoke models or fine-tuning separately for each subject. To address this challenge, we introduce a meta-optimized approach for semantic visual decoding from fMRI that generalizes to novel subjects without any fine-tuning. By simply conditioning on a small set of image-brain activation examples from the new individual, our model rapidly infers their unique neural encoding patterns to facilitate robust and efficient visual decoding. Our approach is explicitly optimized for in-context learning of the new subject's encoding model and performs decoding by hierarchical inference, inverting the encoder. First, for multiple brain regions, we estimate the per-voxel visual response encoder parameters by constructing a context over multiple stimuli and responses. Second, we construct a context consisting of encoder parameters and response values over multiple voxels to perform aggregated functional inversion. We demonstrate strong cross-subject and cross-scanner generalization across diverse visual backbones without retraining or fine-tuning. Moreover, our approach requires neither anatomical alignment nor stimulus overlap. This work is a critical step towards a generalizable foundation model for non-invasive brain decoding.