cs.CYApr 2, 2026

Statistical realism is not evidence that LLMs can estimate treatment effects in social science experiments

Authors: Zonghan Li, Feng Ji

Organizations: Department of Applied Psychology and Human Development, University of Toronto, ON, Canada

Abstract

Large language models (LLMs) are increasingly used to simulate human responses and estimate treatment effect of interventions when real-world experiments are costly or infeasible. The treatment-effect estimates are often evaluated using statistical realism, the degree to which simulated responses reproduce properties of observed human responses, although whether realism predicts treatment-effect accuracy remains unknown. Here we test this proxy relationship by jointly measuring statistical realism and treatment-effect accuracy on the same simulated responses in a cross-national experiment with 59,508 participants from 62 countries using three LLMs. The correlation between statistical realism and treatment-effect accuracy is weak, and optimizing for statistical realism can even worsen treatment-effect accuracy when selecting models, prompts, and target populations. The pattern replicates in two additional cross-national experiments spanning 12 and 27 countries with 20,785 participants. The divergence between the two reflects distinct error structures and is larger for behavioral outcomes, where models appear to extrapolate behavioral effects from attitudinal patterns. Because this divergence may remain hidden in deployment, errors can propagate into simulation-informed decisions. We introduce a diagnostic framework for LLM-generated synthetic data and discuss how treatment-effect validation should proceed under varying availability of experimental benchmarks. Simulated responses and simulated treatment effects are distinct estimation targets, and evidence for one does not certify the other.

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