XSeg: A Large-scale X-ray Contraband Segmentation Benchmark For Real-World Security Screening

X-ray contraband detection is critical for security in large-scale logistics and transportation, yet conventional detectors struggle to adapt to emerging contraband types and lack fundamental visual understanding. Vision-language models (VLMs) offer strong generalization but are hindered by the scarcity of high-quality X-ray image-caption data. To bridge this critical gap, we present MMXray, a meticulously curated benchmark of 52,124 image-caption pairs spanning 28 fine-grained classes of X-ray contraband. To enrich MMXray with realistic occlusion patterns, we further introduce CleanDET, a dedicated synthesis dataset containing clean foreground contraband images from 28 categories and background images with diverse density levels, together with AnyContraSyn, a controllable synthesis method designed to operate on CleanDET. We also develop OnePipe, an extensible pipeline for systematic data curation. Built on MMXray, we propose OneFocus, a unified VLM that supports four core tasks: visual question answering, contraband localization, classification, and image understanding. OneFocus achieves state-of-the-art performance in X-ray contraband understanding and demonstrates robust cross-domain generalization, establishing a strong vision-language baseline for security screening.

Universal object localization in X-ray security inspection is critical for automated threat detection in safety-critical venues. However, unlike everyday RGB images that dominate web-scale visual data, X-ray scans exhibit distinct color patterns, ambiguous boundaries, and compositional structures caused by volumetric superposition. These gaps hinder the direct zero-shot transfer of dense perception foundation models trained on web-scale RGB data. Moreover, annotated X-ray data is scarce and requires expert labeling, limiting both the training of generalizable X-ray native models and the adaptation of RGB foundation models for X-ray data via fine-tuning. Given these challenges, the bright promise of highly generalizable perception models, enabled by data scaling laws in the RGB domain, remains largely out of reach for X-ray inspection. To this end, we introduce LAO-X, a self-supervised adaptation framework that Locates Any Object in X-ray scans using diverse synthesized image--annotation pairs with granularity-aware supervision. LAO-X first designs a saliency-guided X-ray object mining module to separate diverse object instances, which are then used for physics-guided synthesis in the absorbance domain. LAO-X further incorporates an occlusion-controlled curriculum strategy to fine-tune a Segment Anything Model 2 (SAM2) localizer, progressively adapting it to X-ray scans with increasing object counts and overlap levels. Experiments on six X-ray benchmarks show that LAO-X substantially improves category-agnostic localization, achieving 2% to 23% mAP gains over SAM2 and X-ray specific baselines in heavily cluttered scenarios, entirely without human-annotated labels.

X-ray is medicine's most widely used imaging modality, yet remains among its least quantitative. Unlike volumetric modalities like CT or MRI, X-ray collapses 3D anatomy into a 2D projection, causing structures to overlap and anatomical boundaries to be ambiguous, even to experts. As a result, labeling X-ray databases for training general-purpose segmentation systems is impractical, leaving morphometric and functional X-ray analysis confined to narrow anatomical regions and applications. To this end, we present FleXray, a generalist model for anatomical segmentation across the entire body in clinical X-rays. Instead of curating large, manually annotated X-ray datasets, we build a scalable, physics-based generative X-ray data engine. Using existing 3D whole-body CT segmentation datasets and generative image-editing models, we simulate fully-annotated 2D X-rays with diverse appearances, physiological properties, and imaging geometries. Trained on these simulations, FleXray accurately segments 60 anatomical structures across unseen research datasets and in-the-wild X-rays. We further show that FleXray makes X-rays directly amenable to quantitative analysis, enabling automated measurements for disease grading, robust navigation during X-ray-guided interventions, and data-efficient learning of pathological targets. We release the model, code, a full-body X-ray segmentation dataset, and a local, easy-to-use browser-based tool at https://flexray.csail.mit.edu .