LIFE -- an energy efficient advanced continual learning agentic AI framework for frontier systems

The rapid emergence of Large Language Models (LLMs) has catalyzed Agentic artificial intelligence (AI), autonomous systems integrating perception, reasoning, and action into closed-loop pipelines for continuous adaptation. While unlocking transformative applications in mobile edge computing, autonomous systems, and next-generation wireless networks, this paradigm creates fundamental energy challenges through iterative inference and persistent data exchange. Unlike traditional AI where bottlenecks are computational Floating Point Operations (FLOPs), Agentic AI faces compounding computational and communication energy costs. In this survey, we propose an energy accounting framework identifying computational and communication costs across the Perception-Reasoning-Action cycle. We establish a unified taxonomy spanning model simplification, computation control, input and attention optimization, and hardware-aware inference. We explore cross-layer co-design strategies jointly optimizing model parameters, wireless transmissions, and edge resources. Finally, we identify open challenges of federated green learning, carbon-aware agency, 6th generation mobile communication (6G)-native Agentic AI, and self-sustaining systems, providing a roadmap for scalable autonomous intelligence.

Power has become a central bottleneck for AI inference. This problem is becoming more urgent as agentic AI emerges as a major workload class, yet prior power-management techniques focus almost entirely on single-turn LLM serving. Our analysis shows that agentic serving behaves fundamentally differently: each request carries long-lived context that evolves across tool-interleaved turns, and lowering GPU frequency can push the system into a thrashing regime where memory pressure sharply worsens both performance and power efficiency. These observations show that power optimization for agentic serving requires rethinking. We present KAIROS, a context-aware power optimization system for agentic AI serving. KAIROS uses agent context as a first-class control signal to jointly manage GPU frequency, per-instance concurrency, and multi-instance request placement. This enables KAIROS to save power when memory headroom exists while avoiding thrashing and preserving performance targets. At a high level, KAIROS tracks requests at agent granularity, adapts local control to context growth and agent progress, and routes agents across instances to jointly improve power efficiency and memory stability. Evaluated across diverse software and data engineering agentic tasks, KAIROS achieves an average of 27% (up to 39.8%) power reduction while meeting the performance targets.

The integration of Artificial Intelligence (AI) with High-Performance Computing (HPC) is transforming scientific workflows from human-directed pipelines into adaptive systems capable of autonomous decision-making. Large language models (LLMs) play a critical role in autonomous workflows; however, deploying LLM-based agents at scale remains a significant challenge. Single-agent architectures and sequential tool calls often become serialization bottlenecks when executing large-scale simulation campaigns, failing to utilize the massive parallelism of exascale resources. To address this, we present a scalable, hierarchical multi-agent framework for orchestrating high-throughput screening campaigns. Our planner-executor architecture employs a central planning agent to dynamically partition workloads and assign subtasks to a swarm of parallel executor agents. All executor agents interface with a shared Model Context Protocol (MCP) server that orchestrates tasks via the Parsl workflow engine. To demonstrate this framework, we employed the open-weight gpt-oss-120b model to orchestrate a high-throughput screening of the Computation-Ready Experimental (CoRE) Metal-Organic Framework (MOF) database for atmospheric water harvesting. The results demonstrate that the proposed agentic framework enables efficient and scalable execution on the Aurora supercomputer, with low orchestration overhead and high task completion rates. This work establishes a flexible paradigm for LLM-driven scientific automation on HPC systems, with broad applicability to materials discovery and beyond.