cs.CVApr 16, 2026

Efficient Search of Implantable Adaptive Cells for Medical Image Segmentation

Authors: Emil BenedykciukMarcin DenkowskiGrzegorz M. Wójcik

Organizations: Institute of Computer Science and Mathematics, Maria Curie Sklodowska University, Akademicka 9, Lublin, 20-033,, Poland

Abstract

Purpose: Adaptive skip modules can improve medical image segmentation, but searching for them is computationally costly. Implantable Adaptive Cells (IACs) are compact NAS modules inserted into U-Net skip connections, reducing the search space compared with full-network NAS. However, the original IAC framework still requires a 200-epoch differentiable search for each backbone and dataset. Methods: We analyzed the temporal behavior of operations and edges within IAC cells during differentiable search on public medical image segmentation benchmarks. We found that operations selected in the final discrete cell typically emerge among the strongest candidates early in training, and their architecture parameters stabilize well before the final epoch. Based on this, we propose a Jensen--Shannon-divergence-based stability criterion that tracks per-edge operation-importance distributions and progressively prunes low-importance operations during search. The accelerated framework is called IAC-LTH. Results: Across four public benchmarks (ACDC, BraTS, KiTS, AMOS), several 2-D U-Net backbones, and a 2-D nnU-Net pipeline, IAC-LTH discovers IAC cells whose patient-level segmentation performance matches and sometimes slightly exceeds that of cells found by the original full-length search, while reducing wall-clock NAS cost by 3.7x to 16x across datasets and backbones. These results are consistent across architectures, benchmarks, and both non-augmented and augmented training settings, while preserving the gains of IAC-equipped U-Nets over strong attention-based and dense-skip baselines. Conclusion: Competitive IAC architectures can be identified from early-stabilizing operations without running the full search, making adaptive skip-module design more practical for medical image segmentation under realistic computational constraints.

Explore similar work

May 10, 2026eess.IV

XTinyU-Net: Training-Free U-Net Scaling via Initialization-Time Sensitivity

While U-Net architectures remain the gold standard for medical image segmentation, their deployment in resource-constrained environments demands aggressive model compression. However, finding an optimally efficient configuration is computationally prohibitive, typically requiring exhaustive train-and-evaluate cycles to find the smallest model that maintains peak performance. In this paper, we introduce a training-free selection framework to automatically identify ultralightweight, dataset-specific U-Net configurations directly at initialization. We observe that systematically scaling down U-Net channel width induces a sharp transition from a stable performance plateau to representational capacity collapse. To pinpoint this boundary without training, we propose a Jacobian-based sensitivity metric that scores discrete, width-capped U-Net variants using a small set of unlabeled images. By analyzing the total variation of this sensitivity curve, we isolate the smallest stable configuration, which we denote as XTinyU-Net. Evaluated across six diverse medical datasets within the nnU-Net framework, XTinyU-Net achieves segmentation accuracy comparable to the heavy nnU-Net baseline with 400x-1600x fewer parameters, and outperforms contemporary lightweight architectures while utilizing 5x-72x fewer parameters. Code is publicly accessible on https://github.com/alvinkimbowa/nntinyunet.git.
Alvin Kimbowa, Moein Heidari, David Liu +1
Sep 9, 2026cs.CV

LightMedSeg-ISLES: Stroke Lesion Segmentation with 81x Fewer Parameters than nnU-Net

Large networks and ensembles often lead medical image segmentation challenges, but their storage and inference demands complicate deployment. We present LightMedSeg-ISLES, a 1.26-million-parameter pipeline for T1-weighted stroke lesion segmentation in ISLES'26. On a 146-case held-out cohort, flip test-time augmentation produces 0.618 mean Dice and 0.599 lesion-wise F1. A 102.35-million-parameter nnU-Net ResEnc-L produces 0.634 Dice and 0.544 lesion-wise F1 after size filtering. LightMedSeg therefore retains 97.5% of nnU-Net's Dice with 81.4×\times fewer parameters while improving lesion-wise F1 by 0.055. Its four-pass TTA operating point requires 4.7×\times fewer FLOPs per standardized patch than nnU-Net. It also slightly exceeds filtered UNETR++ and nnFormer. Longer training and stronger augmentation add 0.0358 Dice without increasing capacity, establishing a strong single-checkpoint alternative to much larger models.
Giorgi Nikvashvili, Hanxue Gu, Jie Bao +2
Mar 5, 2026cs.CV

LAW & ORDER: Adaptive Spatial Weighting for Medical Diffusion and Segmentation

Medical image analysis depends on accurate segmentation and controllable synthesis, but both tasks face severe spatial imbalance: lesions occupy small regions against large backgrounds. We study adaptive spatial weighting as a task-level design principle and instantiate it in two adapters. LAW learns per-pixel loss weights for mask-conditioned diffusion by modulating a ratio prior with a feature-dependent delta map, with normalization, clamping, and Dice regularization for stability. ORDER improves lightweight segmentation by adding selective bidirectional skip attention with stage-wise confidence gating. On held-out diffusion test sets, LAW lowers FID from 158.13±\pm0.15 to 108.43±\pm0.71 on Polyps, from 144.13±\pm0.31 to 89.51±\pm0.96 on KiTS19, and from 139.22±\pm0.38 to 112.58±\pm0.68 on BRISC, while improving held-out mask-recovery Dice from 0.681±\pm0.013 to 0.825±\pm0.003 on Polyps. When the resulting images are added to nnUNet training, downstream Polyps mDice rises from 71.7±\pm0.4 to 74.1±\pm0.8. On the cleaned Polyps segmentation protocol, the reported ORDER configuration reaches 76.3±\pm1.9 mDice and 67.2±\pm2.0 mIoU at 42K parameters and 0.11 GFLOPs, versus 70.3±\pm1.5 mDice and 59.9±\pm1.7 mIoU for matched MK-UNet. On BRISC under the same training recipe, ORDER reaches 77.4±\pm0.8 mDice and 68.1±\pm0.7 mIoU. These results position adaptive spatial weighting as a practical design idea for both medical diffusion and efficient segmentation.
Anugunj Naman, Ayushman Singh, Gaibo Zhang +1