Multimodal Diffusion to Mutually Enhance Polarized Light and Low Resolution EBSD Data
Authors: Harry Dong, Timofey Efimov, Megna Shah, Jeff Simmons, Sean Donegan, Marc De Graef, Yuejie Chi
Organizations: Department of Electrical and Computer Engineering, Carnegie Mellon University, USA · Materials and Manufacturing Directorate, Air Force Research Laboratory, USA · Department of Materials Science and Engineering, Carnegie Mellon University, USA · Department of Statistics and Data Science, Yale University, USA
In spite of the utility of 3-D electron back-scattered diffraction (EBSD) microscopy, the data collection process can be time-consuming with serial-sectioning. Hence, it is natural to look at other modalities, such as polarized light (PL) data, to accelerate EBSD data collection, supplemented with shared information. Complementarily, features in chaotic PL data could even be enriched with a handful of EBSD measurements. To inherently learn the complex dynamics between EBSD and PL to solve these inverse problems, we use an unconditional multimodal diffusion model, motivated by progress in diffusion models for inverse problems. Although trained solely on synthetic data once, our model has strong generalizable capabilities on real data which can be low-resolution, noisy, corrupted, and misregistered. With inference-time scaling, we show gains in performance on a variety of objectives including grain boundary prediction, super-resolution, and denoising. With our model, we demonstrate that there is little difference from full resolution performance with only 25% (1/4 the resolution) of EBSD data and corrupted PL data.
Land surface temperature (LST) super-resolution is important for environmental monitoring. However, it remains challenging as coarse thermal observations severely underdetermine fine-scale structure. In this paper, we propose Earth Foundation Model-guided Diffusion (EFDiff), a novel framework for super-resolution under extreme spatial degradation. EFDiff uses the Prithvi-EO-2.0 Earth foundation model to encode high-resolution multispectral reflectance into geospatial embeddings, which are injected into the denoising network via cross-attention to guide fine-scale reconstruction from highly degraded observations. We study two variants, EFDiff-ε and EFDiff-x0, which offer complementary trade-offs between perceptual realism and pixel-level fidelity. We evaluate EFDiff under an extreme 32× scale gap using a globally diverse benchmark comprising 242,416 co-registered Landsat thermal-reflectance patches. Results show that EFDiff consistently outperforms baseline methods and that cross-attention conditioning by EFM is more effective than HLS channel concatenation. Although we present EFDiff in the context of LST super-resolution, the framework is broadly applicable to remote sensing problems in which pretrained geospatial representations can guide generative reconstruction.
Understanding and inferring dislocation microstructures from diffraction patterns remains an open challenge in materials characterization, as diffraction measurements provide only indirect information about the underlying dislocation structure. In this work, a cross-modal learning framework is developed to enable the prediction of 3D dislocation structures directly from diffraction data. Dislocation density fields generated from discrete dislocation dynamics simulations are paired with corresponding virtual X-ray diffraction patterns and embedded into a shared 2D latent space using contrastive learning. The alignment between structural and diffraction representations of dislocation structures is evaluated directly in the learned latent space using correlations between corresponding latent features. To estimate the role of dataset size for this approach, farthest point sampling is employed to construct representative and diverse training subsets of varying sizes. The results show strong cross-modal alignment and that model performance improves rapidly with increasing dataset size. Near-saturation is achieved with approximately 500 representative observations from a dataset of 10,000 observations, enabling accurate prediction of dislocation density fields from previously unseen diffraction data of the same distribution. Qualitative comparisons confirm that the predicted structures capture the dominant spatial features of the underlying dislocation microstructures. These findings demonstrate an efficient approach for learning structure-diffraction relationships and highlight the potential for inferring structural characteristics of dislocation networks directly from diffraction patterns, providing a pathway toward diffraction-based structural analysis and future extension to experimental data.
Electron microscopy enables nanoscale cellular visualization but faces a trade-off between imaging resolution and acquisition speed. Existing learning-based methods rely on single-stream architectures that struggle to balance perceptual realism and quantitative fidelity, either over-smoothing details or generating unrealistic hallucinations. This work introduces a frequency-adaptive dual-stream architecture to resolve this conflict. Using discrete wavelet transform, we decompose images into low-frequency structures and high-frequency details, then employ a conditional diffusion model for realistic global synthesis and a transformer network for precise detail recovery. Experiments on the EMDiffuse dataset show the method achieves superior LPIPS and resolution ratio, substantially outperforming existing approaches. The method also shows strong generalization across diverse biological samples, supporting fast and reliable electron microscopy imaging for structural biology and nanotechnology applications. The source code and associated dataset are publicly available to facilitate further research.