HFS-TriNet: A Three-Branch Collaborative Feature Learning Network for Prostate Cancer Classification from TRUS Videos

Real-time video segmentation of the prostate in Transrectal Ultrasound (TRUS) is essential for image-guided interventions. While conventional 2D methods suffer from inter-frame inconsistencies by disregarding temporal context, 3D architectures incur prohibitive latency. To resolve this dilemma, we present a Temporally Consistent Learning Framework that distills temporal coherence into a 2D network during training, preserving single-frame inference efficiency. Our design is driven by a key clinical observation: the prostate exhibits geometric stability, whereas the surrounding acoustic environment fluctuates due to physiological motion and transducer pressure. Because conventional temporal constraints propagate erroneous gradients from these unstable regions, we introduce a Confidence-Weighted Temporal Consistency objective derived from optical flow warping residuals, selectively attenuating contributions from unreliable regions. Complementing this pixel-wise constraint, a Dual-scale Prototype Alignment Module enforces semantic coherence through contrastive optimization of local boundary and global semantic features. Furthermore, to eliminate the need for dense per-frame video annotations, we employ geometric equivariance-based pseudo-labeling with knowledge distillation from a pretrained teacher. Extensive experiments on SUN-SEG and our newly introduced TRUS-V benchmark (2,679 frames) demonstrate state-of-the-art accuracy and temporal consistency at real-time speed. Code and dataset are available at https://github.com/DYDevelop/DTC-TRUS.

Artificial intelligence (AI) analysis of micro-ultrasound ($μ$US) has shown promise for prostate cancer (PCa) detection. However, most existing AI methods focus on the analysis of single $μ$US images in isolation. By contrast, expert $μ$US readers typically assess a full recorded video study, which provides three-dimensional context, to improve PCa detection compared to single-frame analysis. Inspired by this clinical workflow, we propose Compass, a novel AI methodology which models a $μ$US study as a stream of 2D images. Compass jointly integrates rotational sweep videos of the prostate with $μ$US frames acquired at the moment of biopsy, and performs evidence aggregation across the study using a transformer conditioned on the probe's rotational angle. Finally, a decoder head predicts frame-level and study-level risk scores for the patient. The model is trained and evaluated using a multi-center clinical trial dataset of $μ$US studies, including continuous rotational scans of the prostate and videos captured during biopsy acquisition. We compare the proposed method to baseline AI methods from the literature and to risk scores provided by clinical experts. Our framework shows strong performance, highlighting the value of multi-view context for $μ$US PCa detection, and providing a potentially powerful tool to complement human expertise in $μ$US-based PCa diagnosis. Our code is available at: https://github.com/mharmanani/Compass.

Micro-ultrasound ($μ$US) is a new, emerging, and promising imaging modality for prostate cancer (PCa) detection, but accurate identification of suspicious tissue remains highly dependent on clinical experience, leading to substantial inter-observer variability. Machine-learning assistance can reduce this variability; however, training reliable deep models is challenging because supervision is sparse and noisy -- typically limited to core-level histopathology outcomes (e.g., cancer grade and its percentage in a biopsy core) without pixel-level lesion annotations and under severe class imbalance. We introduce Prost-RL, which reframes $μ$US PCa detection as a spatially aware, policy-driven inference problem by learning where to look before decoding. Prost-RL integrates a lightweight reinforcement-learning policy into a foundation-model encoder-decoder to generate interpretable spatial attention maps that act as soft prompts for both cancer-likelihood heatmap prediction and image-level classification. We further propose Adaptive Policy Optimization (APO) to stabilize hybrid supervised-RL training and a noise-robust objective combining symmetric cross-entropy with negative-entropy regularization to mitigate weak-label noise and encourage sharp localization. On a cohort of 6,607 biopsy cores from 693 patients across five clinical sites, Prost-RL achieves $79.0\pm3.5$ AUROC with $64.6\pm6.3$% sensitivity at 80% specificity for core-level detection (+2.1 AUROC and +4.5 sensitivity points over the strongest baseline), and $79.3\pm5.8$ AUROC for clinically significant cancer classification. The learned policy highlights biopsy-aligned regions, providing transparent, spatially grounded evidence alongside quantitative risk predictions. Code is available at: https://github.com/DeepRCL/Prost-RL.