RADMI: Latent Information Aggregation as a Proxy for Model Uncertainty
Authors: William Stevens, Mohit Prabhushankar, Ghassan AlRegib
Organizations: OLIVES at the Center for Signal and Information Processing, School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Epistemic uncertainty estimation is essential for identifying regions where deep learning system outputs may be unreliable. However, existing approaches require computationally expensive ensemble methods or multiple stochastic forward passes, limiting their scalability to dense prediction tasks like segmentation. We propose Resolution-Aggregated Decoder Mutual Information (RADMI), a single-pass method that estimates prediction uncertainty by measuring mutual information (MI) between consecutive decoder layers in segmentation networks. We observe that elevated inter-layer MI correlates with prediction uncertainty, as the network must integrate conflicting contextual information at ambiguous regions such as class boundaries. Evaluating on a seismic facies segmentation benchmark, RADMI achieves the highest correlation with deep ensemble uncertainty among all single-pass methods, outperforming the next-best baselines by 5.5% in Pearson and 10.7% in Spearman correlation coefficients. Compared to baselines that either lack spatial precision or demand significant computational overhead, RADMI yields sharp, boundary-localized uncertainty maps without architectural modifications. Our results suggest that linear aggregation of normalized information flow provides a principled and efficient proxy for prediction uncertainty in encoder-decoder architectures.
In this study, we explore in depth a few under-studied topics at the intersection of uncertainty estimation and segmentation. Prior work has shown that the quality of uncertainty estimates can be very sensitive to a range of variables. As one of the main uses of uncertainty estimation is to help identify and deal with prediction errors in practical scenarios, any factors that affect this must be clearly identified. For example, do more challenging domains or different datasets and architectures result in worse performance when using uncertainty estimates? Can prior frames in a video sequence in fact provide useful uncertainty estimates comparable to other approaches? Is it possible to combine uncertainty estimation approaches, taking advantage of sample diversity, to get better estimates? Finally, when might it make sense to use an ensemble-based uncertainty estimate over a deterministic network? We address these questions by creating a framework for and executing a large scale study across many variables such as datasets, backbones, and downstream tasks, for both semantic and panoptic segmentation. We find that a) the more challenging task of panoptic segmentation usually results in worse performance while high performance variance between datasets and backbones indicates that generalization is not guaranteed, b) time series samples can be useful for specific configurations, but in many cases are not worth the cost, c) sample diversity shows the most promise in the downstream task of calibration, but otherwise fails to beat simpler alternatives, d) a deterministic approach is adequate for some downstream tasks, but ensembles allow for significant improvements if the right conditions can be achieved in deployment.
Ensemble disagreement is widely used as a proxy for epistemic uncertainty in medical image segmentation. In practice, many studies form ensembles via K-fold cross-validation (CV), yet refer to them as ``deep ensembles'' (DE). Because CV members are trained on different data subsets, their disagreement mixes seed-driven variability with data-exposure effects, which can change how uncertainty should be interpreted. We audit recent segmentation uncertainty studies and find that terminology--implementation mismatches are common. We then compare a standard 5-fold CV ensemble to a 5-member DE (fixed training set, different random seeds) under otherwise identical configurations on three multi-rater segmentation datasets spanning three modalities. We evaluate uncertainty for calibration, failure detection, ambiguity modeling, and robustness under distribution shift. DE match segmentation accuracy while improving calibration and failure detection, whereas CV ensembles sometimes correlate more strongly with inter-rater variability on the studied datasets. Thus, ensemble construction should be chosen to match the research question: DE for reliability-oriented use (e.g., selective referral/failure detection) and CV ensembles as a proxy for ambiguity. We provide a lightweight nnU-Net modification enabling DE training within the default pipeline.
Tristan Kirscher, Markus Bujotzek, Yannick Kirchhoff +5
Deep neural networks achieve impressive results across diverse applications, yet their overconfidence on unseen inputs necessitates reliable epistemic uncertainty modeling. Existing methods for uncertainty modeling face a fundamental dilemma: Bayesian approaches provide principled estimates but remain computationally prohibitive, while efficient second-order predictors lack rigorous connections between their specific objectives and epistemic uncertainty quantification. To resolve this dilemma, we introduce Dirichlet-approximated possibilistic posterior predictions (DAPPr), a principled framework grounded in possibility theory. We define a possibilistic posterior over parameters, project it to the prediction space via supremum operators, and approximate the projected posterior using learnable Dirichlet possibility functions. This projection-and-approximation strategy yields a simple training objective with closed-form solutions. Despite its simplicity, extensive experiments across diverse benchmarks show that DAPPr achieves competitive or superior uncertainty quantification performance over state-of-the-art second-order predictors while maintaining both principled derivation and computational efficiency. Code is available at https://github.com/MaxwellYaoNi/DAPPr.