Automated laboratories hold the promise of accelerating scientific discovery, yet their deployment is bottlenecked by the difficulty of designing safe and executable environments. While simulator-based design offers scalability, existing 3D scene generation methods are primarily tailored for household settings, optimizing for visual plausibility while neglecting the protocol grounding and layout-level safety constraints essential for scientific experimentation. We present LabBuilder, an end-to-end system that generates and verifies 3D laboratory layouts from concise textual specifications. It operates through three tightly coupled components: LabForge first curates a meta-dataset of annotated assets and chemical knowledge, translating natural language specifications into structured protocols; building on these protocols, LabGen synthesizes laboratory layouts via an iterative, constraint-aware optimization strategy; finally, LabTouchstone evaluates the resulting layouts as a unified benchmark. Extensive experiments demonstrate that LabBuilder significantly outperforms existing state-of-the-art methods, producing laboratory environments that are realistic and valid under modeled geometric, chemical-safety, and navigation constraints.
Most text-driven 3D indoor scene synthesis methods generate rooms from object-centric prompts, asking what furniture should be placed rather than how the space is used. Yet in real interior design, a layout is judged by how well it supports its occupants, e.g., their activities and physical needs. We introduce Function2Scene, a framework for generating 3D indoor layouts from functional specifications, i.e., natural-language design briefs describing who will use a room and what they need to do there. Given such a specification, our system parses occupant personas and activities, derives a customized set of functional design constraints from a taxonomy of 17 criteria spanning spatial, ergonomic, activity, and environmental considerations, and uses these constraints to guide layout generation. Rather than relying on an LLM to directly produce a final scene, Function2Scene performs iterative evaluation and refinement through a tool-augmented check-and-repair loop, combining geometric measurements, LLM-based contextual reasoning, and VLM-based visual assessment. Experiments on 30 professionally written interior-design cases show that Function2Scene produces layouts that better satisfy functional requirements than recent LLM-based scene synthesis baselines, with our results preferred in 94.3% of pairwise comparisons. Our work reframes text-driven indoor scene synthesis from placing plausible objects to designing spaces that support human use.
We introduce LaviGen, a framework that repurposes 3D generative models for 3D layout generation. Unlike previous methods that infer object layouts from textual descriptions, LaviGen operates directly in the native 3D space, formulating layout generation as an autoregressive process that explicitly models geometric relations and physical constraints among objects, producing coherent and physically plausible 3D scenes. To further enhance this process, we propose an adapted 3D diffusion model that integrates scene, object, and instruction information and employs a dual-guidance self-rollout distillation mechanism to improve efficiency and spatial accuracy. Extensive experiments on the LayoutVLM benchmark show LaviGen achieves superior 3D layout generation performance, with 19% higher physical plausibility than the state of the art and 65% faster computation. Our code is publicly available at https://github.com/fenghora/LaviGen.
Scientific embodied agents are increasingly capable of carrying out laboratory procedures, but executing these procedures safely in dynamic laboratory environments remains challenging. Current safety approaches often overlook the intermediate step of transforming laboratory natural language, including safety rules, manuals, protocols, and standard operating procedures, into machine-checkable runtime constraints. We introduce LabGuard (Laboratory Guard), a language-to-execution safety suite that grounds natural-language laboratory rules into executable specifications and deploys them as runtime guards. LabGuard includes three core components: LabGuard-IR, which defines a typed executable representation; LabGuard-Bench, which provides 812 supervised annotations expanded from 203 seed laboratory rules; and LabGuard-Grounder, which maps natural-language laboratory rules into LabGuard-IR. The resulting IR instances are handled by the LabGuard Pipeline, which compiles them into runtime monitors and applies them at the controller boundary. Experiments show that LabGuard generalizes to unseen laboratory-rule sources, achieves 79.4 task-scope F1, and reduces unsafe events from 39.5% to 23.8% after monitor compilation. In LabUtopia, its runtime monitors integrate with ACT, keeping interventions below 0.5% while preserving task success.