cs.ROMay 8, 2026

BioProVLA-Agent: An Affordable, Protocol-Driven, Vision-Enhanced VLA-Enabled Embodied Multi-Agent System with Closed-Loop-Capable Reasoning for Biological Laboratory Manipulation

Authors: Zhaohui Du, Zhe Wang, Dongzhan Zhou, Minting Pan, Hongmei Fei, Xiwen Cao, Ting Xiao, Qi Wang, +4 more

Organizations: Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of Education, East China University of Science and Technology, Shanghai, CN. · Department of Computer Science and Engineering, East China University of Science and Technology, Shanghai, CN. · AI for Science Center, Shanghai AI Laboratory, Shanghai, CN. · School of Information Science and Technology, Shihezi University, Shihezi, CN. · Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,2026 Shanghai, CN.

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Abstract

Biological laboratory automation can reduce repetitive manual work and improve reproducibility, but reliable embodied execution in wet-lab environments remains challenging. Protocols are often unstructured, labware is frequently transparent or reflective, and multi-step procedures require state-aware execution beyond one-shot instruction following. Existing robotic systems often rely on costly hardware, fixed workflows, dedicated instruments, or robotics-oriented interfaces. Here, we introduce BioProVLA-Agent, an affordable, protocol-driven, vision-enhanced embodied multi-agent system enabled by Vision-Language-Action (VLA) models for biological manipulation. The system uses protocols as the task interface and integrates protocol parsing, visual state verification, and embodied execution in a closed-loop workflow. A Tailored LLM Protocol Agent converts protocols into verifiable subtasks; a VLM-RAG Verification Agent assesses readiness and completion using observations, robot states, retrieved knowledge, and success/failure examples; and a VLA Embodied Agent executes verified subtasks through a lightweight policy. To improve robustness under wet-lab visual perturbations, we develop AugSmolVLA, an online augmentation strategy targeting transparent labware, reflections, illumination shifts, and overexposure. We evaluate the system on a hierarchical benchmark covering 15 atomic tasks, 6 composite workflows, and 3 bimanual tasks, including tube loading, sorting, waste disposal, cap twisting, and liquid pouring. Across normal and high-exposure settings, AugSmolVLA improves execution stability over ACT, X-VLA, and the original SmolVLA, especially for precise placement, transparent-object manipulation, composite workflows, and visually degraded scenes. These results suggest a practical route toward accessible, protocol-centered, and verification-capable embodied AI for biological manipulation.

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