GESR: A Genetic Programming-Based Symbolic Regression Method with Gene Editing

We analyze the effect of optimizing the initial population of genetic programming (GP) for symbolic regression (SR) on the accuracy and complexity of solutions. We compare three well-established random initialization methods as well as initialization with small optimized solutions from exhaustive symbolic regression (ESR) using a GP/SR implementation which is based on the multi-objective evolutionary algorithm NSGA-II. We compare the final Pareto fronts found with each initialization method on twelve synthetic problems of varying complexity and one real-world dataset. We find no significant differences in accuracy or model complexity among the initialization methods. The initial advantage of initialization with ESR disappears after only a few generations. Our results show that, given similar diversity in the initial population, the effect of the initialization method in GP-based symbolic regression on the final Pareto front is negligible.

Symbolic regression via genetic programming routinely fails on small, wide datasets - a regime common in clinical-trial monitoring, biostatistics, and engineering pilot studies - by converging on bloated, overfit expressions that exploit correlation rather than prediction. We present Evolutional Math, an open-source genetic programming system that combines four design choices to yield compact, interpretable formulas in this regime. First, fitness is measured by R-squared on held-out cross-validation folds rather than Pearson correlation on the training set, eliminating single-variable shortcuts that correlate but mis-scale. Second, a multi-island architecture runs independent populations seeded with distinct operator subsets (algebraic, logarithmic, trigonometric, and full) with ring-topology migration every M generations, preventing the search from collapsing into one region of formula space. Third, a structural deduplication scheme treats formulas differing only in constants as equivalent, so the elite archive contains structurally distinct candidates rather than near-duplicate variants. Fourth, top-k individuals undergo numerical constant refinement via scipy L-BFGS-B after each migration phase, decoupling structure search from parameter fitting. We evaluate the system on synthetic benchmarks of the form log(x_i) * x_j / (x_k * c), trigonometric mixtures, and an anonymized clinical site-monitoring dataset with 24 rows and approximately 290 candidate numeric features. The system consistently recovers compact ground-truth structures with R-squared at or above 0.99 within tens of thousands of unique formula evaluations. A reference implementation is released under a noncommercial source-available license.

Constant optimization refines the numerical coefficients of candidate expressions in tree-based genetic programming for symbolic regression. But its per-generation cost has led modern GPU-accelerated frameworks to omit it or restrict it to lightweight forms. We present a GPU-resident, batched Levenberg--Marquardt solver that optimizes constants across a structurally heterogeneous population of expression trees using a fixed number of population-wide CUDA launches per iteration. Reverse-mode automatic differentiation assembles the per-tree Jacobian in one backward sweep, making the dominant per-iteration cost independent of the number of constants per tree, and a double-precision delivery guard guarantees that returned constants are never worse than their initial values. On early-generation populations, the solver sustains up to $5.1{\times}10^{5}$ trees per second on an NVIDIA A100; at a GPU-saturated benchmark configuration it delivers roughly $9.9{\times}$ the throughput of Operon running on a 64-core EPYC 7763, while matching fp64-reference quality. Integrated in-process into EvoGP, the solver enables end-to-end search to recover governing equations on $10$ of $18$ constructed problems versus 0 for stock EvoGP. Our code is at https://github.com/TensorConv/CuSR.