Structural Diversity Drives Disruptive Scientific Innovation

Despite interdisciplinary research leading to larger and longer-term impact, most work remains confined to single-domain academic silos. Recent AI-based approaches to scientific discovery show promise for interdisciplinary research, but many prioritize rapidly designing experiments and solutions, bypassing the exploratory, collaborative reasoning processes that drive creative interdisciplinary breakthroughs. As a result, prior efforts largely prioritize automating scientific discovery rather than augmenting the reasoning processes that underlie scientific disruption. We present Idea-Catalyst, a novel framework that systematically identifies interdisciplinary insights to support creative reasoning in both humans and large language models. Starting from an abstract research goal, Idea-Catalyst is designed to assist the brainstorming stage, explicitly avoiding premature anchoring on specific solutions. The framework embodies key metacognitive features of interdisciplinary reasoning: (a) defining and assessing research goals, (b) awareness of a domain's opportunities and unresolved challenges, and (c) strategic exploration of interdisciplinary ideas based on impact potential. Concretely, Idea-Catalyst decomposes an abstract goal (e.g., improving human-AI collaboration) into core target-domain research questions that guide the analysis of progress and open challenges within that domain. These challenges are reformulated as domain-agnostic conceptual problems, enabling retrieval from external disciplines (e.g., Psychology, Sociology) that address analogous issues. By synthesizing and recontextualizing insights from these domains back into the target domain, Idea-Catalyst ranks source domains by their interdisciplinary potential. Empirically, this targeted integration improves average novelty by 21% and insightfulness by 16%, while remaining grounded in the original research problem.

Scientific novelty drives advances at the research frontier, yet it is also associated with heightened uncertainty and potential resistance from incumbent paradigms, leading to complex patterns of scientific impact. Prior studies have primarily ex-amined the relationship between a single dimension of novelty -- such as theoreti-cal, methodological, or results-based novelty -- and scientific impact. However, because scientific novelty is inherently multidimensional, focusing on isolated dimensions may obscure how different types of novelty jointly shape impact. Consequently, we know little about how combinations of novelty types influence scientific impact. To this end, we draw on a dataset of 15,322 articles published in Nature Communications. Using the DeepSeek-V3 model, we classify articles into three novelty dimensions based on the content of their Introduction sections: theoretical novelty, methodological novelty, and results-based novelty. These dimensions may coexist within the same article, forming distinct novelty configura-tions. Scientific impact is measured using five-year citation counts and indicators of whether an article belongs to the top 1% or top 10% highly cited papers. Descriptive results indicate that results-based novelty alone and the simultaneous presence of all three novelty types are the dominant configurations in the sample. Regression results further show that articles with results-based novelty only re-ceive significantly more citations and are more likely to rank among the top 1% and top 10% highly cited papers than articles exhibiting all three novelty types. These findings advance our understanding of how multidimensional novelty configurations shape knowledge diffusion.

Multi-agent systems (MAS) are increasingly used for open-ended idea generation, driven by the expectation that collective interaction will broaden the exploration diversity. However, when and why such collaboration truly expands the solution space remains unclear. We present a systematic empirical study of diversity in MAS-based ideation across three bottom-up levels: model intelligence, agent cognition, and system dynamics. At the model level, we identify a compute efficiency paradox, where stronger, highly aligned models yield diminishing marginal diversity despite higher per-sample quality. At the cognition level, authority-driven dynamics suppress semantic diversity compared to junior-dominated groups. At the system level, group-size scaling yields diminishing returns and dense communication topologies accelerate premature convergence. We characterize these outcomes as collective failures emerging from structural coupling, a process where interaction inadvertently contracts agent exploration and triggers diversity collapse. Our analysis shows that this collapse arises primarily from the interaction structure rather than inherent model insufficiency, highlighting the importance of preserving independence and disagreement when designing MAS for creative tasks. Our code is available at https://github.com/Xtra-Computing/MAS_Diversity.