What Do Biomedical NER and Entity Linking Benchmarks Measure? A Corpus-Centric Diagnostic Framework

Biomedical NER is deceptively simple for modern LLMs: plausible biomedical mentions are easy to surface, but corpus-convention correctness depends on annotation conventions, span boundaries, entity granularity, and type schemas. Multi-LLM agreement is a salience signal, not corpus-convention correctness. We introduce a candidate-level panel-output benchmark for panel-surfaced candidate verification, where the unit is an aligned candidate surfaced by an explicitly defined multi-model panel rather than a standalone extractor output. The benchmark aligns eight LLMs' predictions over five public biomedical NER datasets into a candidate master table. BioConCal is an in-domain supervised scorer that instantiates this layer with inference-time gold-free agreement, mention, surface-availability, and document features for a fixed candidate stream. In domain, BioConCal improves AUROC from 0.753 for raw agreement to 0.910. At a validation-selected 0.95 precision target it selects 1,340 candidates at empirical test precision 0.939, compared with 293 for raw agreement. This corresponds to candidate-level recall 0.592 and corpus-level recall 0.523 against a within-panel row-label ceiling of 0.883. The main benefit is not recovering entities missed by every panel member, but reshaping a noisy panel stream into a higher-yield review queue. Under entity-type shift, thresholds require target-domain validation, and exact character localization remains a separate deterministic post-processing step.

Biomedical Named Entity Recognition (NER) is fundamental to healthcare AI applications, including clinical decision support and medical information extraction. While corpora with Unified Medical Language System (UMLS) annotations, such as MedMentions, have driven progress in English biomedical NER, no comparable resource exists for Vietnamese. This paper presents En-ViMedNER, the first English-Vietnamese parallel biomedical NER corpus annotated with UMLS semantic types, which are language-neutral codes providing a shared cross-lingual label space and ensuring direct comparability with existing UMLS-based resources. The corpus contains 4,392 PubMed abstract pairs, 44,892 English-Vietnamese sentence pairs, and 202,949 aligned entity-mention pairs across 21 semantic types adapted from the MedMentions ST21pv dataset. To balance quality and scalability, we have constructed the corpus through automatic translation, expert post-editing, LLM-assisted label projection, and human verification and adjudication. We characterize En-ViMedNER as a large-scale silver-standard corpus with a human-audited and consensus-corrected mini-test subset. We evaluate En-ViMedNER in two settings: (i) Vietnamese-input/Vietnamese-output biomedical NER and (ii) English-input/Vietnamese-output cross-lingual NER. For Vietnamese NER, we benchmark Vietnamese-supervised encoder models, English-supervised multilingual encoder models, and prompt-based LLMs. The best model achieves an F1 score of 52.70 on the test set and 53.78 on the mini-test set. For cross-lingual NER, we benchmark encoder-decoder models and prompt-based LLMs. The best model achieves an F1 score of 45.44 on the mini-test set. We publicly release our corpus, corpus construction pipeline, and baseline models to facilitate future Vietnamese biomedical NLP research.

Prion diseases are rare, rapidly progressive, and fatal neurodegenerative disorders that remain difficult to diagnose, particularly in their early stages because of nonspecific clinical presentations. However, to our knowledge, there is no publicly available prion-disease-focused dataset designed to capture a broad range of clinically relevant entities from the biomedical literature. We introduce PrionNER, a manually annotated named entity recognition dataset for prion disease clinical information in PubMed abstracts. The current release comprises 317 abstracts, 2,943 sentences, and 6,955 text-bound entity annotations spanning 15 coarse-grained and 31 fine-grained clinically oriented entity types covering diseases, symptoms, diagnostics, findings, anatomy, treatments, and temporal and statistical evidence. Inter-annotator agreement reaches 81.78 exact-match F1, indicating strong annotation consistency. We benchmark supervised BERT baselines, W2NER, and zero-shot extractors on PrionNER. W2NER is the strongest supervised model, and Gemma-4-31B is the strongest zero-shot model, but the benchmark remains challenging, especially for structurally complex mentions and fine-grained clinically adjacent label distinctions. PrionNER provides a clinically grounded benchmark for prion-disease information extraction and supports research on rare-disease biomedical NLP under low-resource, fine-grained, and non-flat extraction conditions. The dataset, annotation guidelines, and evaluation scripts are available at https://github.com/daotuanan/PrionNER/.