Out-of-distribution (OOD) detection has emerged as a popular technique to enhance the reliability of machine learning models by identifying unexpected inputs from unknown classes. Recent progress in pre-trained vision-language models (VLMs) has enabled zero-shot OOD detection without access to in-distribution (ID) training data; in this setting, existing methods commonly treat text embeddings of class names as class prototypes. In this paper, we challenge the widely adopted text-as-prototype paradigm by theoretically showing that off-the-shelf textual prototypes are generally misaligned with the optimal visual prototypes, yielding an intrinsic modality gap that cannot be eliminated by prompt engineering alone. To mitigate this gap under the post-hoc constraint, this paper presents an online pseudo-supervised framework that directly learns class prototypes in the visual feature space using unlabeled test-time data streams and soft predictions from the pre-trained VLMs. We provide theoretical guarantees for the convergence of the online optimization procedure. Extensive experiments empirically demonstrate that our method achieves a new state of the art across a variety of OOD detection setups.
Recent studies show that using potential out-of-distribution (OOD) labels from large corpora as auxiliary information can improve OOD detection in vision-language models (VLMs). However, these methods often fail when real-world OOD samples fall outside the predefined OOD label set. To address this limitation, we propose DynProto, a novel approach that learns OOD prototypes dynamically during testing using only in-distribution (ID) information. DynProto is inspired by a key observation: OOD samples predicted as the same ID class tend to cluster in the feature space. With this insight, we leverage easy-to-detect OOD samples as ``anchors'' to find their harder-to-detect, similar counterparts. To this end, DynProto introduces two modules: \textbf{Coarse OOD Pattern Capturing Module} caches OOD patterns that are easily confused with each ID class during testing, and \textbf{Fine-grained OOD Pattern Refinement Module} subsequently clusters these patterns within each cache and aggregates them into representative OOD prototypes. By measuring similarity to ID and dynamic OOD prototypes, DynProto enables accurate OOD detection. DynProto significantly outperforms prior methods across multiple benchmarks. On ImageNet OOD benchmark, DynProto reduces FPR95 by 11.60% and improves AUROC by 4.70%. Moreover, the framework is architecture-agnostic and can be integrated into various backbones.
Aiming at identifying unexpected inputs from unknown classes, out-of-distribution (OOD) detection has emerged as a pivotal approach to enhancing the reliability of machine learning models. This paper focuses on the burgeoning paradigm of post-hoc OOD detection with pre-trained vision-language models (VLMs), where a popular pipeline is to detect OOD inputs by examining their affinities between ID labels and negative labels, i.e., those semantically different from ID labels. Due to the unavailability of target OOD labels, existing works predominantly rely on heuristic rules to mine negative labels from unlabeled wild corpus data. Despite the empirical success, we argue that the power of VLM-based OOD detection has yet to be fully unleashed since the notorious false negative problem is far from addressed in the literature. With this motivation, we are interested in addressing the challenge of mining true negative labels for OOD scoring. To this end, we develop a theoretical framework for correcting the sampling bias of negatives labels by indirectly approximating the distribution of negative labels. Perhaps surprisingly, we show that the debiased negative mining can be naturally converted into Monte-Carlo sampling based on ID labels and the unlabeled wild corpus data. Extensive experiments empirically manifest that our method establishes a new state-of-the-art in a variety of OOD detection setups. Code is publicly available at \href{https://github.com/60pen9/Debiased-Negative-Mining-Improves-OOD-Detection-with-Pre-trained-VLMs}{\textcolor{red}{here}}.
Medical vision-language models (VLMs) enable zero-shot clinical image classification, yet reliably detecting out-of-distribution (OOD) inputs at deployment remains an open problem. No static scoring method works across all shift types: Maximum Concept Matching (MCM) on FLAIR achieves 76.4% AUROC for far-OOD but only 42.4% for covariate shifts such as ultra-wide-field fundus images, effectively random. We trace this to a structural mismatch: covariate-shifted inputs are indistinguishable from in-distribution samples in softmax space, yet occupy distinct regions in the VLM embedding space. To exploit this untapped signal, we propose PROTON (PROtotype-based Test-time ONline OOD detection), a lightweight post-hoc module that maintains an online prototype bank from high-confidence test predictions and adaptively fuses prototype distance with MCM scoring via stream-level variance statistics, requiring no model modification, training data, or prompt engineering. On the ophthalmology benchmark FLAIR + FIVES, PROTON improves MCM by +23.9 AUROC on covariate shift, +8.8 on semantic shift, and +8.1 on far-OOD, making it the only zero-shot method to improve all three without hierarchical prompts or labeled data. Code is available at https://github.com/GenMI-Lab/PROTON, and the project page is available at https://genmi-lab.github.io/PROTON.