Automated reproducibility assessments in the social and behavioral sciences using large language models
Authors: Tobias Holtdirk, Pietro Marcolongo, Anna Steinberg Schulten, Felix Henninger, Stefan Rose, Sarah Ball, Bolei Ma, Frauke Kreuter, +2 more
Organizations: 1LMU Munich, Munich, Germany · 2Munich Center for Machine Learning, Munich, Germany · University of Maryland, College Park, USA · University of Cologne, Cologne, Germany
Reproducibility in the social and behavioral sciences is typically evaluated by independent researchers who reanalyze the original data to assess whether the published findings can be recovered. However, such approaches are resource-intensive and difficult to scale. Here, we show that large language models (LLMs) can automate reproducibility assessments. Using N = 180 published studies with predefined claims from the behavioral and social sciences, we compare LLM-generated analyses with the original findings. For 11 studies, the LLM pipeline could not produce a viable effect size estimate. For the remaining studies, the LLM reached the same qualitative conclusion as the original study in 80% of cases, and recovered the original effect sizes (using a +/-0.05 tolerance in Cohen's d) in 24% of studies. In a subset with human reanalyses, the LLM reached the same qualitative conclusion as the original study in 95% of studies, similar to human reanalysts (83%), and the LLM recovered the original effect sizes using a +/-0.05 tolerance in 40% of studies, again broadly similar to human reanalysts (28%). Given the current capabilities and limitations of LLMs, the findings show that LLMs can support systematic audits of empirical results rather than substitute expert judgment. As such, LLMs can serve as a scalable screening tool to improve the rigor and reproducibility in empirical research.
Recent work has used LLM agents to reproduce empirical social science results with access to both the data and code. We broaden this scope by asking: Can they reproduce results given only a paper's methods description and original data? We develop an agentic reproduction system that extracts structured methods descriptions from papers, runs reimplementations under strict information isolation -- agents never see the original code, results, or paper -- and enables deterministic, cell-level comparison of reproduced outputs to the original results. An error attribution step traces discrepancies through the system chain to identify root causes. Evaluating four agent scaffolds and four LLMs on 48 papers with human-verified reproducibility, we find that agents can largely recover published results, but performance varies substantially between models, scaffolds, and papers. Root cause analysis reveals that failures stem both from agent errors and from underspecification in the papers themselves.
Benjamin Kohler, David Zollikofer, Johanna Einsiedler +2
Reproducing research results from papers and released code is central to scientific progress. Existing works have introduced benchmarks to evaluate whether LLM agents can assist with reproducibility, but they are difficult to scale due to their reliance on substantial manual effort for data curation and evaluation. We introduce ReproRepo, a scalable framework for reproducibility evaluation that leverages human-raised GitHub issues as naturally occurring supervision on realistic reproduction blockers. We instantiate ReproRepo on 1,149 recent machine learning papers from major conferences and evaluate four frontier model-agent configurations. Our results show that LLM agents, even without executing code, can identify many real-world reproducibility problems from paper-repository pairs: the best agent in our study, namely Codex with GPT-5.5, surfaces at least one semantically related human-reported blocker for ∼90% of papers in the study. Further analysis shows that agents are particularly effective for surfacing visible failures and identifying the right semantic region, but may still be insufficient in exact localization. ReproRepo can serve as a reusable, scalable framework for future evaluations of LLM agents on real-world reproducibility auditing. Our code is released at https://github.com/LithiumDA/ReproRepo.
Scientific peer review increasingly struggles to assess reproducibility at the scale and complexity of modern research output. Evaluating reproducibility requires reconstructing experimental dependencies, methodological choices, data flows, and result-generating procedures, which often exceeds what human reviewers can provide. Agentic Reproducibility Assessment (ARA) formalizes reproducibility assessment as a structured reasoning task over scientific documents. Given a paper, ARA extracts a directed workflow graph linking sources, methods, experiments, and outputs, then evaluates its reconstructability using structural and content-based scores for reproducibility assessments. Experiments on 213 ReScience C articles - the largest cross-domain benchmark of human-validated computational reproducibility studies considered to date - demonstrate ARA's generalizability and consistent workflow reconstruction and assessment across LLMs, model temperatures, and scientific domains. ARA achieves ~61% accuracy on three benchmarks, and the highest accuracy reported on ReproBench (60.71% vs. 36.84%) and GoldStandardDB (61.68% vs. 43.56%), highlighting its potential to complement human review at scale and enabling next-generation peer review. Code and Data available: https://github.com/AndresLaverdeMarin/agentic_reproducibility_assessment.
Kevin Riehl, Andres L. Marin, Nikofors Zacharof +6