Deep Unrolled Networks in Representation Space Applied to MRI Reconstruction

Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the shared modules directly from limited raw measurements, removing the need for pre-acquired high-quality images. During test-time adaptation, only the subject-specific encoder is optimized, while the shared pair remains frozen, effectively preserving learned priors. Extensive evaluations on three representative medical imaging tasks show that DisINR significantly outperforms state-of-the-art INRs in both reconstruction accuracy and efficiency.

Fully sampled MRI requires dense k-space acquisition, leading to long scan times, reduced clinical throughput, and increased sensitivity to patient motion. Accelerated MRI addresses this by acquiring undersampled k-space data and reconstructing the missing information computationally. However, reconstruction from undersampled measurements is highly ill-posed and can introduce aliasing artifacts, noise amplification, and loss of anatomical detail. Although conventional parallel imaging and compressed sensing methods mitigate these issues, and deep learning methods have further improved reconstruction quality, preserving high-frequency structures under aggressive undersampling remains challenging. In this work, we propose a Variational Network with a Wavelet-based U-Net (W-UNet) for accelerated MRI reconstruction. The framework combines physics-guided iterative reconstruction with learnable multi-scale frequency representations. Standard pooling operations are replaced with Discrete Wavelet Transform and Inverse Wavelet Transform modules, enabling lossless downsampling while preserving low-frequency structure and high-frequency edge details. Integrated into the refinement and sensitivity map estimation stages, the proposed design improves artifact suppression, feature preservation, and reconstruction fidelity in both single-coil and multi-coil settings. Experiments on fastMRI knee and M4Raw brain datasets show state-of-the-art performance. Ablation studies further confirm the effectiveness of wavelet-based feature decomposition for accelerated MRI reconstruction.

Recent Deep Unfolding Networks (DUNs) have significantly advanced Compressive Sensing (CS) by integrating iterative optimization with deep networks. However, existing DUNs still suffer from two challenges: 1) Reliance on a single measurement stream, which limits effective information interaction across distinct measurement subsets. 2) Uniform processing of all image regions, which overlooks varying reconstruction difficulties induced by diverse textures. To address these limitations, a novel Dual-Path Hyperprior Informed Deep Unfolding Network (DPH-DUN) is proposed, which partitions measurements into double subsets to enable hyperprior-guided reconstruction via a dual-path architecture. In the Deep Hyperprior Learning branch, a series of lightweight neural modules are designed to efficiently generate hyperprior knowledge of different domains, enabling collaborative guidance for the CS reconstruction. In the Hyperprior Informed Reconstruction branch, a deep unfolding framework with hyperprior guidance is constructed to iteratively refine reconstruction. Specifically, i) in the gradient descent step, a Hyperprior Informed Step Size Generation network is designed to dynamically generate spatially varying step maps, enabling adaptive fine-grained gradient updates. ii) In the proximal mapping step, two well-designed hyperprior informed attention mechanisms are introduced to dynamically focus on challenging regions via gradient-based hard and soft attentions, facilitating CS reconstruction accuracy. Extensive experiments demonstrate that the proposed DPH-DUN outperforms existing CS methods.